Biomaterial Database

Tardive Meige syndrome responsive to clozapine. 1990

T Van Putten, and W C Wirshing, and S R Marder

UI	MeSH Term	Description	Entries
D008538	Meige Syndrome	A syndrome characterized by orofacial DYSTONIA; including BLEPHAROSPASM; forceful jaw opening; lip retraction; platysma muscle spasm; and tongue protrusion. It primarily affects older adults, with an incidence peak in the seventh decade of life. (From Adams et al., Principles of Neurology, 6th ed, p108)	Blepharospasm-Oromandibular Dystonia,Brueghel Syndrome,Idiopathic Orofacial Dyskinesia,Blepharospasm-Oromandibular Dyskinesia,Blepharospasm-Oromandibular Dystonia Syndrome,Blepharospasm-Oromandibular Dystonia Syndrome, Idiopathic,Idiopathic Blepharospasm-Oromandibular Dystonia Syndrome,Syndrome, Blepharospasm-Oromandibular Dystonia,Blepharospasm Oromandibular Dyskinesia,Blepharospasm Oromandibular Dystonia,Blepharospasm Oromandibular Dystonia Syndrome,Blepharospasm Oromandibular Dystonia Syndrome, Idiopathic,Blepharospasm-Oromandibular Dyskinesias,Blepharospasm-Oromandibular Dystonia Syndromes,Blepharospasm-Oromandibular Dystonias,Dyskinesia, Blepharospasm-Oromandibular,Dyskinesia, Idiopathic Orofacial,Dyskinesias, Blepharospasm-Oromandibular,Dyskinesias, Idiopathic Orofacial,Dystonia Syndrome, Blepharospasm-Oromandibular,Dystonia Syndromes, Blepharospasm-Oromandibular,Dystonia, Blepharospasm-Oromandibular,Dystonias, Blepharospasm-Oromandibular,Idiopathic Blepharospasm Oromandibular Dystonia Syndrome,Idiopathic Orofacial Dyskinesias,Orofacial Dyskinesia, Idiopathic,Orofacial Dyskinesias, Idiopathic
D002908	Chronic Disease	Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care (Dictionary of Health Services Management, 2d ed). For epidemiological studies chronic disease often includes HEART DISEASES; STROKE; CANCER; and diabetes (DIABETES MELLITUS, TYPE 2).	Chronic Condition,Chronic Illness,Chronically Ill,Chronic Conditions,Chronic Diseases,Chronic Illnesses,Condition, Chronic,Disease, Chronic,Illness, Chronic
D003024	Clozapine	A tricylic dibenzodiazepine, classified as an atypical antipsychotic agent. It binds several types of central nervous system receptors, and displays a unique pharmacological profile. Clozapine is a serotonin antagonist, with strong binding to 5-HT 2A/2C receptor subtype. It also displays strong affinity to several dopaminergic receptors, but shows only weak antagonism at the dopamine D2 receptor, a receptor commonly thought to modulate neuroleptic activity. Agranulocytosis is a major adverse effect associated with administration of this agent.	Clozaril,Leponex
D004305	Dose-Response Relationship, Drug	The relationship between the dose of an administered drug and the response of the organism to the drug.	Dose Response Relationship, Drug,Dose-Response Relationships, Drug,Drug Dose-Response Relationship,Drug Dose-Response Relationships,Relationship, Drug Dose-Response,Relationships, Drug Dose-Response
D004359	Drug Therapy, Combination	Therapy with two or more separate preparations given for a combined effect.	Combination Chemotherapy,Polychemotherapy,Chemotherapy, Combination,Combination Drug Therapy,Drug Polytherapy,Therapy, Combination Drug,Chemotherapies, Combination,Combination Chemotherapies,Combination Drug Therapies,Drug Polytherapies,Drug Therapies, Combination,Polychemotherapies,Polytherapies, Drug,Polytherapy, Drug,Therapies, Combination Drug
D004409	Dyskinesia, Drug-Induced	Abnormal movements, including HYPERKINESIS; HYPOKINESIA; TREMOR; and DYSTONIA, associated with the use of certain medications or drugs. Muscles of the face, trunk, neck, and extremities are most commonly affected. Tardive dyskinesia refers to abnormal hyperkinetic movements of the muscles of the face, tongue, and neck associated with the use of neuroleptic agents (see ANTIPSYCHOTIC AGENTS). (Adams et al., Principles of Neurology, 6th ed, p1199)	Dyskinesia, Medication-Induced,Medication-Induced Dyskinesia,Drug-Induced Dyskinesia,Drug-Induced Dyskinesias,Dyskinesia, Drug Induced,Dyskinesia, Medication Induced,Dyskinesias, Drug-Induced,Dyskinesias, Medication-Induced,Medication Induced Dyskinesia,Medication-Induced Dyskinesias
D005260	Female		Females
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000328	Adult	A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available.	Adults
D012559	Schizophrenia	A severe emotional disorder of psychotic depth characteristically marked by a retreat from reality with delusion formation, HALLUCINATIONS, emotional disharmony, and regressive behavior.	Dementia Praecox,Schizophrenic Disorders,Disorder, Schizophrenic,Disorders, Schizophrenic,Schizophrenias,Schizophrenic Disorder