Fetal liver very small embryonic/epiblast like stem cells follow developmental migratory pathway of hematopoietic stem cells. 2009

Ewa K Zuba-Surma, and Magda Kucia, and Liu Rui, and Dong-Myung Shin, and Wojtek Wojakowski, and Janina Ratajczak, and Mariusz Z Ratajczak
Stem Cell Institute at James Graham Brown Cancer Center, University of Louisville, Louisville, Kentucky 40202, USA.

Fetal liver (FL) has been described as a source of both hematopoietic and nonhematopoietic stem cells. Recently we have purified from murine adult bone marrow (BM) a population of CXCR4(+)Oct-4(+)SSEA-1(+)Sca-1(+)Lin(-)CD45(-) very small embryonic/epiblast-like stem cells (VSELs). By employing several complementary imaging and molecular strategies, we report in this study that VSELs, like hematopoietic stem cells (HSCs), are highly enriched in murine FL during the second trimester of gestation. Subsequently, at the beginning of the third trimester of gestation their number decreases, which corresponds to the time when HSCs egress FL and follow the stromal derived factor-1 (SDF-1) gradient in order to colonize developing BM. Thus, our data support the hypothesis that VSELs are a mobile pool of primitive stem cells that respond to similar chemotactic gradients as HSCs and follow their developmental migratory route.

UI MeSH Term Description Entries
D008099 Liver A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances. Livers
D008565 Membrane Proteins Proteins which are found in membranes including cellular and intracellular membranes. They consist of two types, peripheral and integral proteins. They include most membrane-associated enzymes, antigenic proteins, transport proteins, and drug, hormone, and lectin receptors. Cell Membrane Protein,Cell Membrane Proteins,Cell Surface Protein,Cell Surface Proteins,Integral Membrane Proteins,Membrane-Associated Protein,Surface Protein,Surface Proteins,Integral Membrane Protein,Membrane Protein,Membrane-Associated Proteins,Membrane Associated Protein,Membrane Associated Proteins,Membrane Protein, Cell,Membrane Protein, Integral,Membrane Proteins, Integral,Protein, Cell Membrane,Protein, Cell Surface,Protein, Integral Membrane,Protein, Membrane,Protein, Membrane-Associated,Protein, Surface,Proteins, Cell Membrane,Proteins, Cell Surface,Proteins, Integral Membrane,Proteins, Membrane,Proteins, Membrane-Associated,Proteins, Surface,Surface Protein, Cell
D008810 Mice, Inbred C57BL One of the first INBRED MOUSE STRAINS to be sequenced. This strain is commonly used as genetic background for transgenic mouse models. Refractory to many tumors, this strain is also preferred model for studying role of genetic variations in development of diseases. Mice, C57BL,Mouse, C57BL,Mouse, Inbred C57BL,C57BL Mice,C57BL Mice, Inbred,C57BL Mouse,C57BL Mouse, Inbred,Inbred C57BL Mice,Inbred C57BL Mouse
D011247 Pregnancy The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH. Gestation,Pregnancies
D002469 Cell Separation Techniques for separating distinct populations of cells. Cell Isolation,Cell Segregation,Isolation, Cell,Cell Isolations,Cell Segregations,Cell Separations,Isolations, Cell,Segregation, Cell,Segregations, Cell,Separation, Cell,Separations, Cell
D002633 Chemotaxis The movement of cells or organisms toward or away from a substance in response to its concentration gradient. Haptotaxis
D005260 Female Females
D005333 Fetus The unborn young of a viviparous mammal, in the postembryonic period, after the major structures have been outlined. In humans, the unborn young from the end of the eighth week after CONCEPTION until BIRTH, as distinguished from the earlier EMBRYO, MAMMALIAN. Fetal Structures,Fetal Tissue,Fetuses,Mummified Fetus,Retained Fetus,Fetal Structure,Fetal Tissues,Fetus, Mummified,Fetus, Retained,Structure, Fetal,Structures, Fetal,Tissue, Fetal,Tissues, Fetal
D006412 Hematopoietic Stem Cells Progenitor cells from which all blood cells derived. They are found primarily in the bone marrow and also in small numbers in the peripheral blood. Colony-Forming Units, Hematopoietic,Progenitor Cells, Hematopoietic,Stem Cells, Hematopoietic,Hematopoietic Progenitor Cells,Cell, Hematopoietic Progenitor,Cell, Hematopoietic Stem,Cells, Hematopoietic Progenitor,Cells, Hematopoietic Stem,Colony Forming Units, Hematopoietic,Colony-Forming Unit, Hematopoietic,Hematopoietic Colony-Forming Unit,Hematopoietic Colony-Forming Units,Hematopoietic Progenitor Cell,Hematopoietic Stem Cell,Progenitor Cell, Hematopoietic,Stem Cell, Hematopoietic,Unit, Hematopoietic Colony-Forming,Units, Hematopoietic Colony-Forming
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia

Related Publications

Ewa K Zuba-Surma, and Magda Kucia, and Liu Rui, and Dong-Myung Shin, and Wojtek Wojakowski, and Janina Ratajczak, and Mariusz Z Ratajczak
January 2013, Advances in experimental medicine and biology,
Ewa K Zuba-Surma, and Magda Kucia, and Liu Rui, and Dong-Myung Shin, and Wojtek Wojakowski, and Janina Ratajczak, and Mariusz Z Ratajczak
August 2010, Leukemia,
Ewa K Zuba-Surma, and Magda Kucia, and Liu Rui, and Dong-Myung Shin, and Wojtek Wojakowski, and Janina Ratajczak, and Mariusz Z Ratajczak
June 2010, Molecules and cells,
Ewa K Zuba-Surma, and Magda Kucia, and Liu Rui, and Dong-Myung Shin, and Wojtek Wojakowski, and Janina Ratajczak, and Mariusz Z Ratajczak
January 2019, Circulation research,
Ewa K Zuba-Surma, and Magda Kucia, and Liu Rui, and Dong-Myung Shin, and Wojtek Wojakowski, and Janina Ratajczak, and Mariusz Z Ratajczak
January 2011, Methods in cell biology,
Ewa K Zuba-Surma, and Magda Kucia, and Liu Rui, and Dong-Myung Shin, and Wojtek Wojakowski, and Janina Ratajczak, and Mariusz Z Ratajczak
January 2010, European journal of haematology,
Ewa K Zuba-Surma, and Magda Kucia, and Liu Rui, and Dong-Myung Shin, and Wojtek Wojakowski, and Janina Ratajczak, and Mariusz Z Ratajczak
June 2009, The American journal of pathology,
Ewa K Zuba-Surma, and Magda Kucia, and Liu Rui, and Dong-Myung Shin, and Wojtek Wojakowski, and Janina Ratajczak, and Mariusz Z Ratajczak
January 2016, Stem cell investigation,
Ewa K Zuba-Surma, and Magda Kucia, and Liu Rui, and Dong-Myung Shin, and Wojtek Wojakowski, and Janina Ratajczak, and Mariusz Z Ratajczak
April 2014, Stem cells and development,
Ewa K Zuba-Surma, and Magda Kucia, and Liu Rui, and Dong-Myung Shin, and Wojtek Wojakowski, and Janina Ratajczak, and Mariusz Z Ratajczak
November 2013, Stem cells and development,
Copied contents to your clipboard!