Successful treatment of isolated subglottic haemangioma with propranolol alone. 2009

Chris G Jephson, and Francesca Manunza, and Samira Syed, and Nikki A Mills, and John Harper, and Ben E J Hartley
Department of Otolaryngology, Great Ormond Street Hospital for Children, Great Ormond Street, London WC1N 3JH, UK. Jephsc1@gosh.nhs.uk

Subglottic haemangioma is a rare but potentially life threatening condition which requires intervention. Many different treatments have been described with varying degrees of success and complications. Recently, successful treatment with propranolol has been reported in 11 cases of cutaneous haemangiomas and then in two cases of subglottic haemangiomas with extensive cutaneous lesions in conjunction with other treatment modalities. We describe the successful treatment with propranolol, of a stridulous four-month-old child with a 95% obstructing subglottic haemangioma. This was achieved without the need for tracheostomy or any other surgical intervention, and with no reported side effects. We now believe the new discovery of a dramatic response to propranolol allows treatment in the acute setting and following further study may render surgical treatment of subglottic haemangioma obsolete.

UI MeSH Term Description Entries
D007223 Infant A child between 1 and 23 months of age. Infants
D007822 Laryngeal Neoplasms Cancers or tumors of the LARYNX or any of its parts: the GLOTTIS; EPIGLOTTIS; LARYNGEAL CARTILAGES; LARYNGEAL MUSCLES; and VOCAL CORDS. Cancer of Larynx,Laryngeal Cancer,Larynx Neoplasms,Cancer of the Larynx,Larynx Cancer,Neoplasms, Laryngeal,Cancer, Laryngeal,Cancer, Larynx,Cancers, Laryngeal,Cancers, Larynx,Laryngeal Cancers,Laryngeal Neoplasm,Larynx Cancers,Larynx Neoplasm,Neoplasm, Laryngeal,Neoplasm, Larynx,Neoplasms, Larynx
D007828 Laryngoscopy Examination, therapy or surgery of the interior of the larynx performed with a specially designed endoscope. Laryngoscopic Surgical Procedures,Surgical Procedures, Laryngoscopic,Laryngoscopic Surgery,Surgery, Laryngoscopic,Laryngoscopic Surgeries,Laryngoscopic Surgical Procedure,Laryngoscopies,Procedure, Laryngoscopic Surgical,Procedures, Laryngoscopic Surgical,Surgeries, Laryngoscopic,Surgical Procedure, Laryngoscopic
D007829 Laryngostenosis Developmental or acquired stricture or narrowing of the LARYNX. Symptoms of respiratory difficulty depend on the degree of laryngeal narrowing. Laryngeal Stenosis,Acquired Laryngeal Stenosis,Acquired Subglottic Stenosis,Congenital Subglottic Stenosis,Acquired Laryngeal Stenoses,Acquired Subglottic Stenoses,Congenital Subglottic Stenoses,Laryngeal Stenoses,Laryngeal Stenoses, Acquired,Laryngeal Stenosis, Acquired,Laryngostenoses,Stenoses, Acquired Laryngeal,Stenoses, Acquired Subglottic,Stenoses, Congenital Subglottic,Stenoses, Laryngeal,Stenosis, Acquired Laryngeal,Stenosis, Acquired Subglottic,Stenosis, Congenital Subglottic,Stenosis, Laryngeal,Subglottic Stenoses, Acquired,Subglottic Stenoses, Congenital,Subglottic Stenosis, Acquired,Subglottic Stenosis, Congenital
D011433 Propranolol A widely used non-cardioselective beta-adrenergic antagonist. Propranolol has been used for MYOCARDIAL INFARCTION; ARRHYTHMIA; ANGINA PECTORIS; HYPERTENSION; HYPERTHYROIDISM; MIGRAINE; PHEOCHROMOCYTOMA; and ANXIETY but adverse effects instigate replacement by newer drugs. Dexpropranolol,AY-20694,Anaprilin,Anapriline,Avlocardyl,Betadren,Dociton,Inderal,Obsidan,Obzidan,Propanolol,Propranolol Hydrochloride,Rexigen,AY 20694,AY20694,Hydrochloride, Propranolol
D012135 Respiratory Sounds Noises, normal and abnormal, heard on auscultation over any part of the RESPIRATORY TRACT. Breathing Sounds,Crackles,Lung Sounds,Pleural Rub,Rales,Rhonchi,Stridor,Wheezing,Breathing Sound,Crackle,Lung Sound,Pleural Rubs,Rale,Respiratory Sound,Rhonchus,Rub, Pleural,Sound, Breathing,Sound, Lung,Sound, Respiratory,Sounds, Breathing,Sounds, Lung,Stridors,Wheezings
D004305 Dose-Response Relationship, Drug The relationship between the dose of an administered drug and the response of the organism to the drug. Dose Response Relationship, Drug,Dose-Response Relationships, Drug,Drug Dose-Response Relationship,Drug Dose-Response Relationships,Relationship, Drug Dose-Response,Relationships, Drug Dose-Response
D004334 Drug Administration Schedule Time schedule for administration of a drug in order to achieve optimum effectiveness and convenience. Administration Schedule, Drug,Administration Schedules, Drug,Drug Administration Schedules,Schedule, Drug Administration,Schedules, Drug Administration
D005260 Female Females
D005500 Follow-Up Studies Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease. Followup Studies,Follow Up Studies,Follow-Up Study,Followup Study,Studies, Follow-Up,Studies, Followup,Study, Follow-Up,Study, Followup

Related Publications

Chris G Jephson, and Francesca Manunza, and Samira Syed, and Nikki A Mills, and John Harper, and Ben E J Hartley
July 2011, Archives of disease in childhood. Fetal and neonatal edition,
Chris G Jephson, and Francesca Manunza, and Samira Syed, and Nikki A Mills, and John Harper, and Ben E J Hartley
May 2019, BMJ case reports,
Chris G Jephson, and Francesca Manunza, and Samira Syed, and Nikki A Mills, and John Harper, and Ben E J Hartley
January 2015, British journal of nursing (Mark Allen Publishing),
Chris G Jephson, and Francesca Manunza, and Samira Syed, and Nikki A Mills, and John Harper, and Ben E J Hartley
September 2010, Journal of the European Academy of Dermatology and Venereology : JEADV,
Chris G Jephson, and Francesca Manunza, and Samira Syed, and Nikki A Mills, and John Harper, and Ben E J Hartley
January 2013, European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery,
Chris G Jephson, and Francesca Manunza, and Samira Syed, and Nikki A Mills, and John Harper, and Ben E J Hartley
March 2013, The Journal of laryngology and otology,
Chris G Jephson, and Francesca Manunza, and Samira Syed, and Nikki A Mills, and John Harper, and Ben E J Hartley
October 2012, Clinical pediatrics,
Chris G Jephson, and Francesca Manunza, and Samira Syed, and Nikki A Mills, and John Harper, and Ben E J Hartley
August 2013, The Medical journal of Malaysia,
Chris G Jephson, and Francesca Manunza, and Samira Syed, and Nikki A Mills, and John Harper, and Ben E J Hartley
August 2014, Ugeskrift for laeger,
Chris G Jephson, and Francesca Manunza, and Samira Syed, and Nikki A Mills, and John Harper, and Ben E J Hartley
May 1997, Archives of disease in childhood,
Copied contents to your clipboard!