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Using the RELP analysis we studied the frequency of X2 allele of apoB gene in three groups of patients: 1) men at the age of 20-59 with lipid metabolism disorders revealed in population inspection of Oktyabrsky district in Moscow; 2) men with ischaemic heart disease and 3) healthy men. It was established that in individuals suffering from type IIa hyperlipidemia the frequency of X2 allele was significantly higher than in healthy donors from Moscow population. Homozygotes for X2 allele of XbaI RELP had 7-9% higher serum cholesterol levels, than homozygotes for X1 allele. The study suggests the X2 allele of the apoB gene to be associated with the development of high plasma cholesterol level. No significant difference in X2 allele frequencies was found between patients with ischaemic heart disease and healthy donors. There was also no association found between cholesterol and triglyceride levels and the presence of X2 allele in this group of patients.
A P Poliakov, and
M V Telkov, and
A N Nikiforov, and
N P Solov'eva, and
V A Koshechkin, and
I M Zhukova, and
A P Surguchev
February 1986,
Kardiologiia,
A P Poliakov, and
M V Telkov, and
A N Nikiforov, and
N P Solov'eva, and
V A Koshechkin, and
I M Zhukova, and
A P Surguchev
March 1992,
Kardiologiia,
A P Poliakov, and
M V Telkov, and
A N Nikiforov, and
N P Solov'eva, and
V A Koshechkin, and
I M Zhukova, and
A P Surguchev
January 1986,
Laboratornoe delo,
A P Poliakov, and
M V Telkov, and
A N Nikiforov, and
N P Solov'eva, and
V A Koshechkin, and
I M Zhukova, and
A P Surguchev
May 1979,
Kardiologiia,
A P Poliakov, and
M V Telkov, and
A N Nikiforov, and
N P Solov'eva, and
V A Koshechkin, and
I M Zhukova, and
A P Surguchev
January 1981,
Zeitschrift fur Alternsforschung,
A P Poliakov, and
M V Telkov, and
A N Nikiforov, and
N P Solov'eva, and
V A Koshechkin, and
I M Zhukova, and
A P Surguchev
January 1987,
Przeglad lekarski,
A P Poliakov, and
M V Telkov, and
A N Nikiforov, and
N P Solov'eva, and
V A Koshechkin, and
I M Zhukova, and
A P Surguchev
April 1968,
Ceskoslovenska gastroenterologie a vyziva,
A P Poliakov, and
M V Telkov, and
A N Nikiforov, and
N P Solov'eva, and
V A Koshechkin, and
I M Zhukova, and
A P Surguchev
October 1983,
Vrachebnoe delo,
A P Poliakov, and
M V Telkov, and
A N Nikiforov, and
N P Solov'eva, and
V A Koshechkin, and
I M Zhukova, and
A P Surguchev
November 1978,
Vrachebnoe delo,
A P Poliakov, and
M V Telkov, and
A N Nikiforov, and
N P Solov'eva, and
V A Koshechkin, and
I M Zhukova, and
A P Surguchev
March 1983,
Kardiologiia,
