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We have investigated the possibility of interspecies scaling of relationships between the structure and total plasma clearance in a group of nine organic acids (iododerivatives of benzoic, phenylacetic and hippuric acids) in rabbits, rats and mice. The intercompound comparison established the dependence of total plasma clearance predominantly on the molecular structure in all the animals under study, but the dependence on drug lipophilicity was also meaningful. For interspecies scaling of total plasma clearance, the use of a biological clock with an effective renal plasma flow as the unit seemed most suitable and is probably connected with the principal role of the kidney in the elimination of the compounds under study.
M Láznícek, and
A Láznícková, and
M Stĕtovská, and
J Kvĕtina
July 1994,
Pharmaceutical research,
M Láznícek, and
A Láznícková, and
M Stĕtovská, and
J Kvĕtina
June 1985,
The Journal of antimicrobial chemotherapy,
M Láznícek, and
A Láznícková, and
M Stĕtovská, and
J Kvĕtina
December 1983,
The American journal of physiology,
M Láznícek, and
A Láznícková, and
M Stĕtovská, and
J Kvĕtina
January 1990,
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M Láznícek, and
A Láznícková, and
M Stĕtovská, and
J Kvĕtina
January 1989,
Health physics,
M Láznícek, and
A Láznícková, and
M Stĕtovská, and
J Kvĕtina
January 1984,
Drug metabolism reviews,
M Láznícek, and
A Láznícková, and
M Stĕtovská, and
J Kvĕtina
August 1995,
Risk analysis : an official publication of the Society for Risk Analysis,
M Láznícek, and
A Láznícková, and
M Stĕtovská, and
J Kvĕtina
October 1994,
Journal of clinical pharmacology,
M Láznícek, and
A Láznícková, and
M Stĕtovská, and
J Kvĕtina
March 1994,
The Journal of pharmacy and pharmacology,
M Láznícek, and
A Láznícková, and
M Stĕtovská, and
J Kvĕtina
October 1992,
Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology,
