BIOMAT Database Logo BIOMAT Database Logo

Toxoplasma gondii infection during pregnancy: T lymphocyte subpopulations in mothers and fetuses. 1990

P Hohlfeld, and F Forestier, and S Marion, and P Thulliez, and P Marcon, and F Daffos
Service de Médecine, Institut de Puériculture de Paris, France.

Prenatal diagnosis of fetal toxoplasmosis is possible with the use of fetal blood sampling, amniocentesis and ultrasound examination. The purpose of this study was to describe T lymphocyte subsets (CD3, CD4 and CD8) in mothers and their fetuses when Toxoplasma gondii infection occurred during pregnancy. Maternal and fetal blood samples were obtained in 86 cases and 9 fetuses showed T. gondii infection. Control groups consisted of 30 healthy nonpregnant women and 30 pregnant women. Pregnant women with T. gondii infection showed an increase in the suppressor (CD8) T subpopulation and a significant depression in the total helper (CD4) T cells. These alterations were more important in mothers whose fetus was infected. We showed the progressive maturation of the fetal immune system with a regular increase of all T lymphocyte subsets. Marked alterations were observed in the 9 infected fetuses (depression of CD4 population and lower CD4/CD8 ratio). In the future these differences might be used as a new marker of the severity of fetal lesions and become a useful diagnostic tool.

UI MeSH Term Description Entries
D007958 Leukocyte Count The number of WHITE BLOOD CELLS per unit volume in venous BLOOD. A differential leukocyte count measures the relative numbers of the different types of white cells. Blood Cell Count, White,Differential Leukocyte Count,Leukocyte Count, Differential,Leukocyte Number,White Blood Cell Count,Count, Differential Leukocyte,Count, Leukocyte,Counts, Differential Leukocyte,Counts, Leukocyte,Differential Leukocyte Counts,Leukocyte Counts,Leukocyte Counts, Differential,Leukocyte Numbers,Number, Leukocyte,Numbers, Leukocyte
D011247 Pregnancy The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH. Gestation,Pregnancies
D011251 Pregnancy Complications, Infectious The co-occurrence of pregnancy and an INFECTION. The infection may precede or follow FERTILIZATION. Complications, Infectious Pregnancy,Infectious Pregnancy Complications,Maternal Sepsis,Pregnancy, Infectious Complications,Sepsis during Pregnancy,Sepsis in Pregnancy,Infectious Pregnancy Complication,Pregnancy Complication, Infectious,Sepsis in Pregnancies,Sepsis, Maternal
D005260 Female Females
D005315 Fetal Diseases Pathophysiological conditions of the FETUS in the UTERUS. Some fetal diseases may be treated with FETAL THERAPIES. Embryopathies,Disease, Fetal,Diseases, Fetal,Embryopathy,Fetal Disease
D006377 T-Lymphocytes, Helper-Inducer Subpopulation of CD4+ lymphocytes that cooperate with other lymphocytes (either T or B) to initiate a variety of immune functions. For example, helper-inducer T-cells cooperate with B-cells to produce antibodies to thymus-dependent antigens and with other subpopulations of T-cells to initiate a variety of cell-mediated immune functions. Helper Cell,Helper Cells,Helper T Cell,Helper-Inducer T-Lymphocytes,Inducer Cell,Inducer Cells,T-Cells, Helper-Inducer,T-Lymphocytes, Helper,T-Lymphocytes, Inducer,Helper T-Cells,Cell, Helper T,Cells, Helper T,Helper Inducer T Lymphocytes,Helper T Cells,Helper T-Cell,Helper T-Lymphocyte,Helper T-Lymphocytes,Helper-Inducer T-Cell,Helper-Inducer T-Cells,Helper-Inducer T-Lymphocyte,Inducer T-Lymphocyte,Inducer T-Lymphocytes,T Cell, Helper,T Cells, Helper,T Cells, Helper Inducer,T Lymphocytes, Helper,T Lymphocytes, Helper Inducer,T Lymphocytes, Inducer,T-Cell, Helper,T-Cell, Helper-Inducer,T-Cells, Helper,T-Lymphocyte, Helper,T-Lymphocyte, Helper-Inducer,T-Lymphocyte, Inducer
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D014123 Toxoplasmosis The acquired form of infection by Toxoplasma gondii in animals and man. Toxoplasma gondii Infection,Infection, Toxoplasma gondii
D015496 CD4-Positive T-Lymphocytes A critical subpopulation of T-lymphocytes involved in the induction of most immunological functions. The HIV virus has selective tropism for the T4 cell which expresses the CD4 phenotypic marker, a receptor for HIV. In fact, the key element in the profound immunosuppression seen in HIV infection is the depletion of this subset of T-lymphocytes. T4 Cells,T4 Lymphocytes,CD4-Positive Lymphocytes,CD4 Positive T Lymphocytes,CD4-Positive Lymphocyte,CD4-Positive T-Lymphocyte,Lymphocyte, CD4-Positive,Lymphocytes, CD4-Positive,T-Lymphocyte, CD4-Positive,T-Lymphocytes, CD4-Positive,T4 Cell,T4 Lymphocyte
D016176 T-Lymphocyte Subsets A classification of T-lymphocytes, especially into helper/inducer, suppressor/effector, and cytotoxic subsets, based on structurally or functionally different populations of cells. T-Cell Subset,T-Cell Subsets,T-Lymphocyte Subset,Subset, T-Cell,Subset, T-Lymphocyte,Subsets, T-Cell,Subsets, T-Lymphocyte,T Cell Subset,T Cell Subsets,T Lymphocyte Subset,T Lymphocyte Subsets

Related Publications

P Hohlfeld, and F Forestier, and S Marion, and P Thulliez, and P Marcon, and F Daffos
T-cell subpopulations of fetuses infected by Toxoplasma gondii.
June 1989, European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology,
P Hohlfeld, and F Forestier, and S Marion, and P Thulliez, and P Marcon, and F Daffos
Toxoplasma gondii infection during pregnancy.
February 2017, Journal of Taibah University Medical Sciences,
P Hohlfeld, and F Forestier, and S Marion, and P Thulliez, and P Marcon, and F Daffos
Management of Toxoplasma gondii infection during pregnancy.
August 2008, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America,
P Hohlfeld, and F Forestier, and S Marion, and P Thulliez, and P Marcon, and F Daffos
Toxoplasma gondii: lymphocyte function during acute infection in mice.
August 1982, Experimental parasitology,
P Hohlfeld, and F Forestier, and S Marion, and P Thulliez, and P Marcon, and F Daffos
Toxoplasma gondii infection in pregnancy.
October 2007, The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases,
P Hohlfeld, and F Forestier, and S Marion, and P Thulliez, and P Marcon, and F Daffos
T-lymphocyte subpopulations in pregnancy.
January 1983, Biological research in pregnancy and perinatology,
P Hohlfeld, and F Forestier, and S Marion, and P Thulliez, and P Marcon, and F Daffos
Cellular immunopathogenesis in primary Toxoplasma gondii infection during pregnancy.
September 2018, Parasite immunology,
P Hohlfeld, and F Forestier, and S Marion, and P Thulliez, and P Marcon, and F Daffos
[The relationship among congenital Toxoplasma gondii infection, pregnancy outcome and T lymphocyte subsets in umbilical cord blood].
January 2012, Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine],
P Hohlfeld, and F Forestier, and S Marion, and P Thulliez, and P Marcon, and F Daffos
Changes in T-lymphocyte subpopulations during pregnancy complicated by human immunodeficiency virus infection.
December 1992, American journal of obstetrics and gynecology,
P Hohlfeld, and F Forestier, and S Marion, and P Thulliez, and P Marcon, and F Daffos
Toxoplasma gondii infection and self-directed violence in mothers.
November 2012, Archives of general psychiatry,
Copied contents to your clipboard!