Biomaterial Database

The protective effect of two porcine enterovirus vaccines in swine. 1977

D T Hazlett, and J B Derbyshire

Piglets vaccinated with a single oral dose of live porcine enterovirus strain T80 were protected to a highly significant degree against an oral challenge dose of 140 plaque forming units of T80 virus, in comparison with nonvaccinated controls, in terms of serum antibody response, titres and distribution of virus in the gastrointestinal tract contents and tissues and duration of virus excretion in the feces. Piglets vaccinated with multiple doses of adjuvanted, PE60-concentrated ethylenimine-inactivated virus administered both orally and subcutaneously showed only a slight degree of protection against the same challenge dose, despite the fact that they possessed high serum antibody titres at the time of challenge. Piglets vaccinated orally with live virus showed a degree of protection even against a challenge dose of 10(7.41) plaque forming units of T80 virus in terms of titres and distribution of virus in the gastrointestinal tract and duration of excretion of virus in the feces. Protection in the piglets dosed orally with live virus appeared to be attributable to the presence of relatively high levels of virus neutralizing antibody of the IgA class in the gastrointestinal tract.

UI	MeSH Term	Description	Entries
D007279	Injections, Subcutaneous	Forceful administration under the skin of liquid medication, nutrient, or other fluid through a hollow needle piercing the skin.	Subcutaneous Injections,Injection, Subcutaneous,Subcutaneous Injection
D012007	Rectum	The distal segment of the LARGE INTESTINE, between the SIGMOID COLON and the ANAL CANAL.	Rectums
D004064	Digestive System	A group of organs stretching from the MOUTH to the ANUS, serving to breakdown foods, assimilate nutrients, and eliminate waste. In humans, the digestive system includes the GASTROINTESTINAL TRACT and the accessory glands (LIVER; BILIARY TRACT; PANCREAS).	Ailmentary System,Alimentary System
D004769	Enterovirus Infections	Diseases caused by ENTEROVIRUS.	Infections, Enterovirus,Enterovirus Infection,Infection, Enterovirus
D004770	Enterovirus	A genus of the family PICORNAVIRIDAE whose members preferentially inhabit the intestinal tract of a variety of hosts. The genus contains many species. Newly described members of human enteroviruses are assigned continuous numbers with the species designated "human enterovirus".	Coxsackie Viruses,Coxsackieviruses
D004771	Enteroviruses, Porcine	Species of ENTEROVIRUS causing mild to severe neurological diseases among pigs especially in Eastern Europe. Mild strains are also present in Canada, U.S., and Australia. Specific species include Porcine enterovirus A and Porcine enterovirus B.	Porcine Enteroviruses,Porcine enterovirus A,Porcine enterovirus B,Enterovirus, Porcine,Porcine Enterovirus
D000284	Administration, Oral	The giving of drugs, chemicals, or other substances by mouth.	Drug Administration, Oral,Administration, Oral Drug,Oral Administration,Oral Drug Administration,Administrations, Oral,Administrations, Oral Drug,Drug Administrations, Oral,Oral Administrations,Oral Drug Administrations
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D000914	Antibodies, Viral	Immunoglobulins produced in response to VIRAL ANTIGENS.	Viral Antibodies
D013552	Swine	Any of various animals that constitute the family Suidae and comprise stout-bodied, short-legged omnivorous mammals with thick skin, usually covered with coarse bristles, a rather long mobile snout, and small tail. Included are the genera Babyrousa, Phacochoerus (wart hogs), and Sus, the latter containing the domestic pig (see SUS SCROFA).	Phacochoerus,Pigs,Suidae,Warthogs,Wart Hogs,Hog, Wart,Hogs, Wart,Wart Hog