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We tested the effects of acetaminophen on cultured rat embryo development. When added directly to culture media at 300 microM, a concentration approximately twice the human therapeutic blood level, acetaminophen caused abnormalities in the cultured embryos. Sera from both rats and monkeys following gavage with acetaminophen were also toxic to cultured embryos. The sera toxicities were related to acetaminophen concentrations, and the toxicity could be removed by serum dialysis. With regard to the metabolism of acetaminophen, glutathione levels in the yolk sac decreased in a concentration related fashion with addition of the drug. Also, buthionine sulfoximine, an inhibitor of glutathione synthesis, appeared to enhance acetaminophen embryo toxicity, and N-acetylcysteine, a glutathione precursor, appeared to protect embryos from acetaminophen toxicity. These results suggested that acetaminophen embryo toxicity resulted from direct exposure of embryos to acetaminophen and not a maternal metabolite.
B S Weeks, and
P Gamache, and
N W Klein, and
J A Hinson, and
M Bruno, and
E Khairallah
January 1999,
Teratogenesis, carcinogenesis, and mutagenesis,
B S Weeks, and
P Gamache, and
N W Klein, and
J A Hinson, and
M Bruno, and
E Khairallah
May 2008,
Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition,
B S Weeks, and
P Gamache, and
N W Klein, and
J A Hinson, and
M Bruno, and
E Khairallah
June 1992,
Anesthesiology,
B S Weeks, and
P Gamache, and
N W Klein, and
J A Hinson, and
M Bruno, and
E Khairallah
June 1982,
Toxicology letters,
B S Weeks, and
P Gamache, and
N W Klein, and
J A Hinson, and
M Bruno, and
E Khairallah
October 1990,
The Journal of pharmacology and experimental therapeutics,
B S Weeks, and
P Gamache, and
N W Klein, and
J A Hinson, and
M Bruno, and
E Khairallah
May 1993,
Toxicology in vitro : an international journal published in association with BIBRA,
B S Weeks, and
P Gamache, and
N W Klein, and
J A Hinson, and
M Bruno, and
E Khairallah
January 1997,
Toxicology and applied pharmacology,
B S Weeks, and
P Gamache, and
N W Klein, and
J A Hinson, and
M Bruno, and
E Khairallah
November 1991,
Teratology,
B S Weeks, and
P Gamache, and
N W Klein, and
J A Hinson, and
M Bruno, and
E Khairallah
October 2008,
Anatomia, histologia, embryologia,
B S Weeks, and
P Gamache, and
N W Klein, and
J A Hinson, and
M Bruno, and
E Khairallah
September 2003,
Pharmacology & toxicology,
