Distribution of heme oxygenase-2 and NADPH-diaphorase in the spinal trigeminal nucleus of the rat. 2009

Wenguo Fan, and Fang Huang, and Weiguo Dong, and Zhixiong Gao, and Cuixia Li, and Xiao Zhu, and Dongpei Li, and Hongwen He
Department of Oral Anatomy and Physiology, Guanghua School of Stomatology, Sun Yat-sen University, Guangzhou, China. fwg1207@tom.com

Heme oxygenase (HO)/carbon monoxide (CO) and nitric oxide synthase (NOS)/nitric oxide (NO) systems are involved in sensory information processing. The present study was undertaken to examine the distribution of HO-2 and NOS in the spinal trigeminal nucleus (STN) of the rat, using histochemistry and immunohistochemistry. Nicotinamide adenine dinucleotide phosphate-diaphorase (NADPH-d) staining was found that NADPH-d activity was more prominent in the nucleus caudalis (Vc) and the dorsomedial subdivision of the nucleus oralis (Vo) than in other spinal trigeminal regions. Immunohistochemistry for HO-2 revealed that HO-2 staining neurons distributed extensively, which intensity was higher in the rostral than caudal part of the STN. The colocalization of NADPH-d and HO-2 was mainly confined in the Vc. The expression and distribution of NADPH-d and HO-2 suggest that NO and CO are likely neurotransmitters and might function in the processing orofacial signal in the STN together.

UI MeSH Term Description Entries
D007150 Immunohistochemistry Histochemical localization of immunoreactive substances using labeled antibodies as reagents. Immunocytochemistry,Immunogold Techniques,Immunogold-Silver Techniques,Immunohistocytochemistry,Immunolabeling Techniques,Immunogold Technics,Immunogold-Silver Technics,Immunolabeling Technics,Immunogold Silver Technics,Immunogold Silver Techniques,Immunogold Technic,Immunogold Technique,Immunogold-Silver Technic,Immunogold-Silver Technique,Immunolabeling Technic,Immunolabeling Technique,Technic, Immunogold,Technic, Immunogold-Silver,Technic, Immunolabeling,Technics, Immunogold,Technics, Immunogold-Silver,Technics, Immunolabeling,Technique, Immunogold,Technique, Immunogold-Silver,Technique, Immunolabeling,Techniques, Immunogold,Techniques, Immunogold-Silver,Techniques, Immunolabeling
D008297 Male Males
D009252 NADPH Dehydrogenase A flavoprotein that reversibly oxidizes NADPH to NADP and a reduced acceptor. EC 1.6.99.1. NADP Dehydrogenase,NADP Diaphorase,NADPH Diaphorase,Old Yellow Enzyme,TPN Diaphorase,Dehydrogenase, NADP,Dehydrogenase, NADPH,Diaphorase, NADP,Diaphorase, NADPH,Diaphorase, TPN,Enzyme, Old Yellow
D009474 Neurons The basic cellular units of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the NERVOUS SYSTEM. Nerve Cells,Cell, Nerve,Cells, Nerve,Nerve Cell,Neuron
D006419 Heme Oxygenase (Decyclizing) A mixed function oxidase enzyme which during hemoglobin catabolism catalyzes the degradation of heme to ferrous iron, carbon monoxide and biliverdin in the presence of molecular oxygen and reduced NADPH. The enzyme is induced by metals, particularly cobalt. Haem Oxygenase,Heme Oxygenase,Oxygenase, Haem,Oxygenase, Heme
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D013194 Staining and Labeling The marking of biological material with a dye or other reagent for the purpose of identifying and quantitating components of tissues, cells or their extracts. Histological Labeling,Staining,Histological Labelings,Labeling and Staining,Labeling, Histological,Labelings, Histological,Stainings
D014279 Trigeminal Nucleus, Spinal Nucleus of the spinal tract of the trigeminal nerve. It is divided cytoarchitectonically into three parts: oralis, caudalis (TRIGEMINAL CAUDAL NUCLEUS), and interpolaris. Nucleus, Spinal Trigeminal,Spinal Trigeminal Nucleus
D017207 Rats, Sprague-Dawley A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company. Holtzman Rat,Rats, Holtzman,Sprague-Dawley Rat,Rats, Sprague Dawley,Holtzman Rats,Rat, Holtzman,Rat, Sprague-Dawley,Sprague Dawley Rat,Sprague Dawley Rats,Sprague-Dawley Rats
D051381 Rats The common name for the genus Rattus. Rattus,Rats, Laboratory,Rats, Norway,Rattus norvegicus,Laboratory Rat,Laboratory Rats,Norway Rat,Norway Rats,Rat,Rat, Laboratory,Rat, Norway,norvegicus, Rattus

Related Publications

Wenguo Fan, and Fang Huang, and Weiguo Dong, and Zhixiong Gao, and Cuixia Li, and Xiao Zhu, and Dongpei Li, and Hongwen He
August 2008, Journal of molecular histology,
Wenguo Fan, and Fang Huang, and Weiguo Dong, and Zhixiong Gao, and Cuixia Li, and Xiao Zhu, and Dongpei Li, and Hongwen He
May 1995, Neuroreport,
Wenguo Fan, and Fang Huang, and Weiguo Dong, and Zhixiong Gao, and Cuixia Li, and Xiao Zhu, and Dongpei Li, and Hongwen He
August 1994, Neuroscience,
Wenguo Fan, and Fang Huang, and Weiguo Dong, and Zhixiong Gao, and Cuixia Li, and Xiao Zhu, and Dongpei Li, and Hongwen He
January 1999, Journal fur Hirnforschung,
Wenguo Fan, and Fang Huang, and Weiguo Dong, and Zhixiong Gao, and Cuixia Li, and Xiao Zhu, and Dongpei Li, and Hongwen He
January 2006, Cellular and molecular neurobiology,
Wenguo Fan, and Fang Huang, and Weiguo Dong, and Zhixiong Gao, and Cuixia Li, and Xiao Zhu, and Dongpei Li, and Hongwen He
January 2002, Somatosensory & motor research,
Wenguo Fan, and Fang Huang, and Weiguo Dong, and Zhixiong Gao, and Cuixia Li, and Xiao Zhu, and Dongpei Li, and Hongwen He
June 2000, The Histochemical journal,
Wenguo Fan, and Fang Huang, and Weiguo Dong, and Zhixiong Gao, and Cuixia Li, and Xiao Zhu, and Dongpei Li, and Hongwen He
January 1997, Brain research,
Wenguo Fan, and Fang Huang, and Weiguo Dong, and Zhixiong Gao, and Cuixia Li, and Xiao Zhu, and Dongpei Li, and Hongwen He
January 1998, Acta anatomica,
Wenguo Fan, and Fang Huang, and Weiguo Dong, and Zhixiong Gao, and Cuixia Li, and Xiao Zhu, and Dongpei Li, and Hongwen He
February 1996, Cell and tissue research,
Copied contents to your clipboard!