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BACKGROUND It is not known whether patients with normal baseline left ventricular (LV) function who develop right ventricular (RV) pacing-induced cardiomyopathy as a result of dual-chamber pacing can benefit from cardiac resynchronization therapy (CRT). We retrospectively assessed the effect of a CRT upgrade on RV pacing-induced cardiomyopathy. RESULTS We reviewed the charts of patients who received a CRT device for RV pacing-induced cardiomyopathy. We assessed the effects of CRT on LV function, recovery, and other response parameters. From September 2005 through February 2009, 21 patients (13 men; aged 63 + or - 9 years) underwent a treatment upgrade to a CRT system. Before the dual-chamber pacemaker was implanted, the LV ejection fraction (LVEF) was 53 + or - 2.3%. After pacing, the LVEF was 31.2 + or - 3.8%, the LV end-diastolic dimension (LVEDD) was 5.8 + or - 0.5 cm, and B-type natriuretic peptide (BNP) levels were 426 + or - 149 pg/mL. The duration of pacing before documentation of pacing-induced cardiomyopathy was 3.8 + or - 1.5 months. All the patients had been on a stable medical regimen for at least 2 months. After the upgrade to CRT, the follow-up time was 4.9 + or - 0.9 months. Sixteen patients (76%) reported a significant improvement in their symptoms. After the CRT upgrade, the LVEF increased to 37.4 + or - 9.0% (P < 0.01 vs pre-CRT). The LVEDD decreased to 5.0 + or - 1.0 cm (P = 0.03 vs pre-CRT), and BNP levels decreased to 139 + or - 92 pg/mL (P = 0.08 vs pre-CRT). CONCLUSIONS A CRT upgrade is an effective treatment for RV pacing-induced cardiomyopathy and should be implemented as soon as the diagnosis is established. Unfortunately, about 24% of our patients did not respond to the upgrade.
Alireza Nazeri, and
Ali Massumi, and
Abdi Rasekh, and
Mohammad Saeed, and
Christopher Frank, and
Mehdi Razavi
March 2011,
Pacing and clinical electrophysiology : PACE,
Alireza Nazeri, and
Ali Massumi, and
Abdi Rasekh, and
Mohammad Saeed, and
Christopher Frank, and
Mehdi Razavi
February 2024,
Pacing and clinical electrophysiology : PACE,
Alireza Nazeri, and
Ali Massumi, and
Abdi Rasekh, and
Mohammad Saeed, and
Christopher Frank, and
Mehdi Razavi
July 2013,
Chinese medical journal,
Alireza Nazeri, and
Ali Massumi, and
Abdi Rasekh, and
Mohammad Saeed, and
Christopher Frank, and
Mehdi Razavi
January 2022,
Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology,
Alireza Nazeri, and
Ali Massumi, and
Abdi Rasekh, and
Mohammad Saeed, and
Christopher Frank, and
Mehdi Razavi
February 2018,
JACC. Clinical electrophysiology,
Alireza Nazeri, and
Ali Massumi, and
Abdi Rasekh, and
Mohammad Saeed, and
Christopher Frank, and
Mehdi Razavi
March 2022,
Heart failure reviews,
Alireza Nazeri, and
Ali Massumi, and
Abdi Rasekh, and
Mohammad Saeed, and
Christopher Frank, and
Mehdi Razavi
June 2021,
Clinical research in cardiology : official journal of the German Cardiac Society,
Alireza Nazeri, and
Ali Massumi, and
Abdi Rasekh, and
Mohammad Saeed, and
Christopher Frank, and
Mehdi Razavi
October 2009,
The American journal of cardiology,
Alireza Nazeri, and
Ali Massumi, and
Abdi Rasekh, and
Mohammad Saeed, and
Christopher Frank, and
Mehdi Razavi
February 2018,
JACC. Clinical electrophysiology,
Alireza Nazeri, and
Ali Massumi, and
Abdi Rasekh, and
Mohammad Saeed, and
Christopher Frank, and
Mehdi Razavi
January 2009,
American journal of therapeutics,
