Comparative study of chronic kidney disease in dogs and cats: induction of myofibroblasts. 2010

A Yabuki, and S Mitani, and M Fujiki, and K Misumi, and Y Endo, and N Miyoshi, and O Yamato
Laboratory of Veterinary Clinical Pathology, Department of Veterinary Medicine, Kagoshima University, Japan. yabu@agri.kagoshima-u.ac.jp

We investigated the kidneys of dogs and cats to clarify whether renal myofibroblasts induction is associated with the severity of chronic kidney disease (CKD). Immunohistochemical expression of myofibroblast markers, alpha-smooth muscle actin (SMA) and vimentin, were evaluated quantitatively. The degrees of glomerulosclerosis, glomerular hypertrophy, interstitial cell infiltration, and interstitial fibrosis were also evaluated quantitatively. The plasma creatinine (pCre) concentrations correlated with glomerulosclerosis, cell infiltration, and fibrosis in dogs, and only with fibrosis in cats. The alpha-SMA expression correlated with pCre, glomerulosclerosis, cell infiltration, and fibrosis in dogs, and with pCre and fibrosis in cats. Tubular vimentin expression correlated with fibrosis in cats, but not in dogs. Interstitial vimentin expression correlated with pCre, glomerulosclerosis, cell infiltration, and fibrosis in dogs, but only with pCre in cats. In conclusion, it was suggested that the severity of CKD in dogs and cats was mediated by different pathways associated with myofibroblasts expression.

UI MeSH Term Description Entries
D007668 Kidney Body organ that filters blood for the secretion of URINE and that regulates ion concentrations. Kidneys
D007676 Kidney Failure, Chronic The end-stage of CHRONIC RENAL INSUFFICIENCY. It is characterized by the severe irreversible kidney damage (as measured by the level of PROTEINURIA) and the reduction in GLOMERULAR FILTRATION RATE to less than 15 ml per min (Kidney Foundation: Kidney Disease Outcome Quality Initiative, 2002). These patients generally require HEMODIALYSIS or KIDNEY TRANSPLANTATION. ESRD,End-Stage Renal Disease,Renal Disease, End-Stage,Renal Failure, Chronic,Renal Failure, End-Stage,Chronic Kidney Failure,End-Stage Kidney Disease,Chronic Renal Failure,Disease, End-Stage Kidney,Disease, End-Stage Renal,End Stage Kidney Disease,End Stage Renal Disease,End-Stage Renal Failure,Kidney Disease, End-Stage,Renal Disease, End Stage,Renal Failure, End Stage
D002371 Cat Diseases Diseases of the domestic cat (Felis catus or F. domesticus). This term does not include diseases of the so-called big cats such as CHEETAHS; LIONS; tigers, cougars, panthers, leopards, and other Felidae for which the heading CARNIVORA is used. Feline Diseases,Cat Disease,Disease, Cat,Disease, Feline,Diseases, Cat,Diseases, Feline,Feline Disease
D002415 Cats The domestic cat, Felis catus, of the carnivore family FELIDAE, comprising over 30 different breeds. The domestic cat is descended primarily from the wild cat of Africa and extreme southwestern Asia. Though probably present in towns in Palestine as long ago as 7000 years, actual domestication occurred in Egypt about 4000 years ago. (From Walker's Mammals of the World, 6th ed, p801) Felis catus,Felis domesticus,Domestic Cats,Felis domestica,Felis sylvestris catus,Cat,Cat, Domestic,Cats, Domestic,Domestic Cat
D003404 Creatinine Creatinine Sulfate Salt,Krebiozen,Salt, Creatinine Sulfate,Sulfate Salt, Creatinine
D004283 Dog Diseases Diseases of the domestic dog (Canis familiaris). This term does not include diseases of wild dogs, WOLVES; FOXES; and other Canidae for which the heading CARNIVORA is used. Canine Diseases,Canine Disease,Disease, Canine,Disease, Dog,Diseases, Canine,Diseases, Dog,Dog Disease
D004285 Dogs The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065) Canis familiaris,Dog
D005921 Glomerulonephritis Inflammation of the renal glomeruli (KIDNEY GLOMERULUS) that can be classified by the type of glomerular injuries including antibody deposition, complement activation, cellular proliferation, and glomerulosclerosis. These structural and functional abnormalities usually lead to HEMATURIA; PROTEINURIA; HYPERTENSION; and RENAL INSUFFICIENCY. Bright Disease,Kidney Scarring,Glomerulonephritides,Scarring, Kidney
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia

Related Publications

A Yabuki, and S Mitani, and M Fujiki, and K Misumi, and Y Endo, and N Miyoshi, and O Yamato
July 2012, The Veterinary clinics of North America. Small animal practice,
A Yabuki, and S Mitani, and M Fujiki, and K Misumi, and Y Endo, and N Miyoshi, and O Yamato
November 2016, The Veterinary clinics of North America. Small animal practice,
A Yabuki, and S Mitani, and M Fujiki, and K Misumi, and Y Endo, and N Miyoshi, and O Yamato
May 2021, The Veterinary clinics of North America. Small animal practice,
A Yabuki, and S Mitani, and M Fujiki, and K Misumi, and Y Endo, and N Miyoshi, and O Yamato
January 2022, Animals : an open access journal from MDPI,
A Yabuki, and S Mitani, and M Fujiki, and K Misumi, and Y Endo, and N Miyoshi, and O Yamato
November 2006, Journal of the American Society of Nephrology : JASN,
A Yabuki, and S Mitani, and M Fujiki, and K Misumi, and Y Endo, and N Miyoshi, and O Yamato
December 2017, Veterinary research communications,
A Yabuki, and S Mitani, and M Fujiki, and K Misumi, and Y Endo, and N Miyoshi, and O Yamato
April 2014, Journal of the American Veterinary Medical Association,
A Yabuki, and S Mitani, and M Fujiki, and K Misumi, and Y Endo, and N Miyoshi, and O Yamato
January 2023, The Veterinary clinics of North America. Small animal practice,
A Yabuki, and S Mitani, and M Fujiki, and K Misumi, and Y Endo, and N Miyoshi, and O Yamato
February 2012, Pediatric nephrology (Berlin, Germany),
A Yabuki, and S Mitani, and M Fujiki, and K Misumi, and Y Endo, and N Miyoshi, and O Yamato
February 2018, Veterinary journal (London, England : 1997),
Copied contents to your clipboard!