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Does orthodontic tooth movement cause an elevation in systemic inflammatory markers? 2010

J K MacLaine, and A B M Rabie, and R Wong
Orthodontics, Faculty of Dentistry, University of Hong Kong China, Hong Kong SAR, China.

The aim of this study was to evaluate the effects of orthodontic treatment on systemic levels of the inflammatory markers, C-reactive protein (CRP), tumour necrosis factor-alpha (TNF-alpha), and interleukin-6 (IL-6). The study group comprised 11 girls and 6 boys (mean age 13.1 years) treated with fixed appliances and distalizing headgear. Venous blood samples were taken from the cubital vein of each subject before treatment (T0) and then at three further time points during treatment (T1-T3), 2 months apart. The sera from these blood samples were analysed using enzyme-linked immunosorbent assay (ELISA) assay technology for CRP, TNF-alpha, and IL-6 concentration levels. Data were compared between baseline and subsequent sequential time points using a Mann-Whitney test for non-normally distributed variables. The results showed that there was no significant elevation of any of the three inflammatory markers at any of the time points. This research provides evidence that conventional orthodontic treatment is not associated with a systemic immune response in the factors investigated.

UI MeSH Term Description Entries
D008297 Male Males
D009967 Orthodontic Appliances Devices used for influencing tooth position. Orthodontic appliances may be classified as fixed or removable, active or retaining, and intraoral or extraoral. (Boucher's Clinical Dental Terminology, 4th ed, p19) Appliance, Orthodontic,Appliances, Orthodontic,Orthodontic Appliance
D002097 C-Reactive Protein A plasma protein that circulates in increased amounts during inflammation and after tissue damage. C-Reactive Protein measured by more sensitive methods often for coronary heart disease risk assessment is referred to as High Sensitivity C-Reactive Protein (hs-CRP). High Sensitivity C-Reactive Protein,hs-CRP,hsCRP,C Reactive Protein,High Sensitivity C Reactive Protein
D002648 Child A person 6 to 12 years of age. An individual 2 to 5 years old is CHILD, PRESCHOOL. Children
D005115 Extraoral Traction Appliances Extraoral devices for applying force to the dentition in order to avoid some of the problems in anchorage control met with in intermaxillary traction and to apply force in directions not otherwise possible. Chincap, Orthodontic,Face Bow, Orthodontic,Headgear, Orthodontic,Appliance, Extraoral Traction,Appliances, Extraoral Traction,Bow, Orthodontic Face,Bows, Orthodontic Face,Chincaps, Orthodontic,Extraoral Traction Appliance,Face Bows, Orthodontic,Headgears, Orthodontic,Orthodontic Chincap,Orthodontic Chincaps,Orthodontic Face Bow,Orthodontic Face Bows,Orthodontic Headgear,Orthodontic Headgears,Traction Appliance, Extraoral,Traction Appliances, Extraoral
D005260 Female Females
D005500 Follow-Up Studies Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease. Followup Studies,Follow Up Studies,Follow-Up Study,Followup Study,Studies, Follow-Up,Studies, Followup,Study, Follow-Up,Study, Followup
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000293 Adolescent A person 13 to 18 years of age. Adolescence,Youth,Adolescents,Adolescents, Female,Adolescents, Male,Teenagers,Teens,Adolescent, Female,Adolescent, Male,Female Adolescent,Female Adolescents,Male Adolescent,Male Adolescents,Teen,Teenager,Youths
D013997 Time Factors Elements of limited time intervals, contributing to particular results or situations. Time Series,Factor, Time,Time Factor

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