Effects of short interval intracortical inhibition and intracortical facilitation on short interval intracortical facilitation in human primary motor cortex. 2009

Aparna Wagle-Shukla, and Zhen Ni, and Carolyn A Gunraj, and Nina Bahl, and Robert Chen
Toronto Western Hospital, 399 Bathurst Street, Toronto, Ontario M5T 2S8, Canada.

Short interval intracortical facilitation (SICF) can be elicited by transcranial magnetic stimulation (TMS) of the motor cortex (M1) with a suprathreshold first stimulus (S1) followed by a subthreshold second stimulus (S2). SICF occurs at three distinct phases and is likely to be related to the generation of indirect (I) waves. Short interval intracortical inhibition (SICI) is an inhibitory phenomenon and intracortical facilitation (ICF) is an excitatory phenomenon occurring in the M1 that can be studied with TMS. We studied the interactions between SICI/ICF and SICF in 17 healthy subjects. Six experiments were conducted. The first experiment examined the effects of different S1 intensities on SICI, ICF and SICF at three peaks. The effects of SICI on SICF were tested by a triple-pulse TMS protocol in the second experiment. We performed Experiments 3-5 to further test the interactions between SICI and SICF with various strengths of SICI, at SICF peaks and troughs, and with SICF generated by different current direction which preferentially generates late I waves. The effects of ICF on SICF were examined in Experiment 6. The results showed that ICF and SICF decreased whereas SICI increased with higher S1 intensities. SICI facilitated SICF mediated by late I waves both at the peaks and the troughs of SICF. The increase of SICF in the presence of SICI correlated to the strength of SICI. ICF decreased the third peak of SICF. We conclude that SICI facilitates SICF at neuronal circuits responsible for generating late I waves through disinhibition, while ICF may have the opposite effects.

UI MeSH Term Description Entries
D007395 Interneurons Most generally any NEURONS which are not motor or sensory. Interneurons may also refer to neurons whose AXONS remain within a particular brain region in contrast to projection neurons, which have axons projecting to other brain regions. Intercalated Neurons,Intercalated Neuron,Interneuron,Neuron, Intercalated,Neurons, Intercalated
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D009044 Motor Cortex Area of the FRONTAL LOBE concerned with primary motor control located in the dorsal PRECENTRAL GYRUS immediately anterior to the central sulcus. It is comprised of three areas: the primary motor cortex located on the anterior paracentral lobule on the medial surface of the brain; the premotor cortex located anterior to the primary motor cortex; and the supplementary motor area located on the midline surface of the hemisphere anterior to the primary motor cortex. Brodmann Area 4,Brodmann Area 6,Brodmann's Area 4,Brodmann's Area 6,Premotor Cortex and Supplementary Motor Cortex,Premotor and Supplementary Motor Cortices,Anterior Central Gyrus,Gyrus Precentralis,Motor Area,Motor Strip,Precentral Gyrus,Precentral Motor Area,Precentral Motor Cortex,Premotor Area,Premotor Cortex,Primary Motor Area,Primary Motor Cortex,Secondary Motor Areas,Secondary Motor Cortex,Somatic Motor Areas,Somatomotor Areas,Supplementary Motor Area,Area 4, Brodmann,Area 4, Brodmann's,Area 6, Brodmann,Area 6, Brodmann's,Area, Motor,Area, Precentral Motor,Area, Premotor,Area, Primary Motor,Area, Secondary Motor,Area, Somatic Motor,Area, Somatomotor,Area, Supplementary Motor,Brodmann's Area 6s,Brodmanns Area 4,Brodmanns Area 6,Central Gyrus, Anterior,Cortex, Motor,Cortex, Precentral Motor,Cortex, Premotor,Cortex, Primary Motor,Cortex, Secondary Motor,Cortices, Secondary Motor,Gyrus, Anterior Central,Gyrus, Precentral,Motor Area, Precentral,Motor Area, Primary,Motor Area, Secondary,Motor Area, Somatic,Motor Areas,Motor Cortex, Precentral,Motor Cortex, Primary,Motor Cortex, Secondary,Motor Strips,Precentral Motor Areas,Precentral Motor Cortices,Premotor Areas,Primary Motor Areas,Primary Motor Cortices,Secondary Motor Area,Secondary Motor Cortices,Somatic Motor Area,Somatomotor Area,Supplementary Motor Areas
D011999 Recruitment, Neurophysiological The spread of response if stimulation is prolonged. (Campbell's Psychiatric Dictionary, 8th ed.) Recruitment, Motor Unit,Motor Unit Recruitment,Neurophysiological Recruitment
D003627 Data Interpretation, Statistical Application of statistical procedures to analyze specific observed or assumed facts from a particular study. Data Analysis, Statistical,Data Interpretations, Statistical,Interpretation, Statistical Data,Statistical Data Analysis,Statistical Data Interpretation,Analyses, Statistical Data,Analysis, Statistical Data,Data Analyses, Statistical,Interpretations, Statistical Data,Statistical Data Analyses,Statistical Data Interpretations
D004576 Electromyography Recording of the changes in electric potential of muscle by means of surface or needle electrodes. Electromyogram,Surface Electromyography,Electromyograms,Electromyographies,Electromyographies, Surface,Electromyography, Surface,Surface Electromyographies
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000200 Action Potentials Abrupt changes in the membrane potential that sweep along the CELL MEMBRANE of excitable cells in response to excitation stimuli. Spike Potentials,Nerve Impulses,Action Potential,Impulse, Nerve,Impulses, Nerve,Nerve Impulse,Potential, Action,Potential, Spike,Potentials, Action,Potentials, Spike,Spike Potential

Related Publications

Aparna Wagle-Shukla, and Zhen Ni, and Carolyn A Gunraj, and Nina Bahl, and Robert Chen
September 2010, Journal of neurophysiology,
Aparna Wagle-Shukla, and Zhen Ni, and Carolyn A Gunraj, and Nina Bahl, and Robert Chen
February 2012, The journal of pain,
Aparna Wagle-Shukla, and Zhen Ni, and Carolyn A Gunraj, and Nina Bahl, and Robert Chen
January 2018, Frontiers in neuroscience,
Aparna Wagle-Shukla, and Zhen Ni, and Carolyn A Gunraj, and Nina Bahl, and Robert Chen
January 2021, Brain stimulation,
Aparna Wagle-Shukla, and Zhen Ni, and Carolyn A Gunraj, and Nina Bahl, and Robert Chen
December 2022, Experimental brain research,
Aparna Wagle-Shukla, and Zhen Ni, and Carolyn A Gunraj, and Nina Bahl, and Robert Chen
October 2008, Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology,
Aparna Wagle-Shukla, and Zhen Ni, and Carolyn A Gunraj, and Nina Bahl, and Robert Chen
November 2009, The Journal of physiology,
Aparna Wagle-Shukla, and Zhen Ni, and Carolyn A Gunraj, and Nina Bahl, and Robert Chen
September 2013, Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology,
Aparna Wagle-Shukla, and Zhen Ni, and Carolyn A Gunraj, and Nina Bahl, and Robert Chen
November 2008, The Journal of physiology,
Aparna Wagle-Shukla, and Zhen Ni, and Carolyn A Gunraj, and Nina Bahl, and Robert Chen
January 2009, Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology,
Copied contents to your clipboard!