-transparent.png){kind=logo}
Innocuity testing in bovines remains the reference method but other methods using mice and especially cell cultures may be employed. Different techniques (dialysis, neutralization, elution, etc.) allow the elimination of toxic constituents of the vaccine while respecting the eventual presence of small quantities of active virus. The sensitivity of the cell cultures is certainly equal if not superior to that of the tongue of bovines. Interference phenomena do not intervene and, furthermore, there is not reason to fear them solely on cell cultures. From the purely statistical standpoint, it is hardly possible to prove the innocuity of a vaccine but the credit which sould be accorded to the innocuity test can be reinforced by a good control of the inactivation process and, a posteriori, by the repetition of negative results.
G Dannacher, and
M Fédida, and
M Coudert, and
M Perrin
January 1976,
Developments in biological standardization,
G Dannacher, and
M Fédida, and
M Coudert, and
M Perrin
May 1969,
Veterinariia,
G Dannacher, and
M Fédida, and
M Coudert, and
M Perrin
January 1948,
Wiener tierarztliche Monatsschrift,
G Dannacher, and
M Fédida, and
M Coudert, and
M Perrin
April 2001,
Biologist (London, England),
G Dannacher, and
M Fédida, and
M Coudert, and
M Perrin
September 1984,
Archiv fur experimentelle Veterinarmedizin,
G Dannacher, and
M Fédida, and
M Coudert, and
M Perrin
June 1970,
The Journal of hygiene,
G Dannacher, and
M Fédida, and
M Coudert, and
M Perrin
September 1972,
Veterinariia,
G Dannacher, and
M Fédida, and
M Coudert, and
M Perrin
March 1949,
Deutsche tierarztliche Wochenschrift,
G Dannacher, and
M Fédida, and
M Coudert, and
M Perrin
January 1947,
Schweizerische Zeitschrift fur Pathologie und Bakteriologie. Revue suisse de pathologie et de bacteriologie,
G Dannacher, and
M Fédida, and
M Coudert, and
M Perrin
September 1977,
Veterinariia,
