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Mg2+ at micromolar concentrations greatly enhanced [3H]N-(1-(2-thienyl)cyclohexyl)-3,4-piperidine ([3H]TCP) binding to well-washed rat cortical membranes, whereas [3H]TCP binding was inhibited by Mg2+ at concentrations higher than 1 mM. In the presence of either L-glutamate (10 microM) or glycine (10 microM), 30 microM Mg2+ caused further stimulation of [3H]TCP binding, suggesting that a high-affinity site for Mg2+ is distinct from the glutamate or glycine binding site. These findings indicate that Mg2+ acts on at least two different recognition sites, e.g. a novel high-affinity site for Mg2+ which stimulates [3H]TCP binding and the Mg2+ recognition site located within the ion channel.
T Hori, and
T Yamamoto, and
K Hatta, and
T Moroji
February 1990,
Journal of neurochemistry,
T Hori, and
T Yamamoto, and
K Hatta, and
T Moroji
October 1989,
Brain research,
T Hori, and
T Yamamoto, and
K Hatta, and
T Moroji
November 1990,
Molecular pharmacology,
T Hori, and
T Yamamoto, and
K Hatta, and
T Moroji
January 1989,
Synapse (New York, N.Y.),
T Hori, and
T Yamamoto, and
K Hatta, and
T Moroji
January 1989,
Life sciences,
T Hori, and
T Yamamoto, and
K Hatta, and
T Moroji
April 1991,
Journal of neurochemistry,
T Hori, and
T Yamamoto, and
K Hatta, and
T Moroji
December 1989,
Neuroscience letters,
T Hori, and
T Yamamoto, and
K Hatta, and
T Moroji
November 1994,
Neuroscience letters,
T Hori, and
T Yamamoto, and
K Hatta, and
T Moroji
June 1986,
Neuroscience letters,
T Hori, and
T Yamamoto, and
K Hatta, and
T Moroji
September 1990,
Neuroscience research,
