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Bgl II-restriction fragment length polymorphism of the insulin receptor gene in patients with type-II diabetes mellitus. 1990
Institute of Biochemistry, School of Medicine, Ernst Moritz Arndt University, Greifswald, FRG.
As an approach to estimate the involvement of the insulin receptor gene in the etiopathogenesis of type-II diabetes mellitus we determined the distribution of the alleles of a restriction fragment length polymorphism of this gene (Bgl II-RFLP) in a group of type-II diabetics. The patients had been characterized by insulin and C-peptide values during OGTT and insulin receptor binding indices. The difference in allelic distribution to a healthy control group (10% "+"-allele in diabetics versus 18% in control persons), was not significant in chi 2-analysis.
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