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[Routine physico-chemical testing of concentrated virulent and inactivated foot-and-mouth disease virus antigens]. 1976

P Adamowicz, and J Guerche, and J Galampoix, and P Prunet

The ponderal quantity of 140 S antigens and their peptide distribution are controlled in concentrated virulent and inactivated preparations proir to their being transformed into vaccines. A certain variability in the amount of 140 S particles and in the titer of peptide sensitive to trypsin (VP1) has been demonstrated in the virulent preparations. After treatment by inactivating agents (glycidaldehyde, binary ethyleneimine and formaldehyde) two types of alteration of the viral capsid are shown : one leads to the partial cleavage of VP1 (glycidaldehyde and binary ethyleneimine), the other leads to the detaching of an important quantity of VP1 from the capsid (formaldehyde). The degradation by formadehyde of the 140 S particles of type O and type C into 12 S particles is underlined, as well as the relatuve stability of type A and the relatuve lability of type C. The results are discussed in terms of immunogenicity.

UI MeSH Term Description Entries
D010455 Peptides Members of the class of compounds composed of AMINO ACIDS joined together by peptide bonds between adjacent amino acids into linear, branched or cyclical structures. OLIGOPEPTIDES are composed of approximately 2-12 amino acids. Polypeptides are composed of approximately 13 or more amino acids. PROTEINS are considered to be larger versions of peptides that can form into complex structures such as ENZYMES and RECEPTORS. Peptide,Polypeptide,Polypeptides
D005029 Ethylenediamines Derivatives of ethylenediamine (the structural formula NH2CH2CH2NH2).
D005537 Aphthovirus A genus of the family PICORNAVIRIDAE infecting mainly cloven-hoofed animals. They cause vesicular lesions and upper respiratory tract infections. FOOT AND MOUTH DISEASE VIRUS is the type species. Equine rhinitis A virus,Equine rhinovirus 1,Aphthoviruses
D005557 Formaldehyde A highly reactive aldehyde gas formed by oxidation or incomplete combustion of hydrocarbons. In solution, it has a wide range of uses: in the manufacture of resins and textiles, as a disinfectant, and as a laboratory fixative or preservative. Formaldehyde solution (formalin) is considered a hazardous compound, and its vapor toxic. (From Reynolds, Martindale The Extra Pharmacopoeia, 30th ed, p717) Formalin,Formol,Methanal,Oxomethane
D005985 Glyceraldehyde An aldotriose containing the propionaldehyde structure with hydroxy groups at the 2- and 3-positions. It is involved in the formation of ADVANCED GLYCOSYLATION END PRODUCTS.
D000956 Antigens, Viral Substances elaborated by viruses that have antigenic activity. Viral Antigen,Viral Antigens,Antigen, Viral
D014357 Trypsin A serine endopeptidase that is formed from TRYPSINOGEN in the pancreas. It is converted into its active form by ENTEROPEPTIDASE in the small intestine. It catalyzes hydrolysis of the carboxyl group of either arginine or lysine. EC 3.4.21.4. Tripcellim,Trypure,beta-Trypsin,beta Trypsin
D014765 Viral Vaccines Suspensions of attenuated or killed viruses administered for the prevention or treatment of infectious viral disease. Viral Vaccine,Vaccine, Viral,Vaccines, Viral
D014774 Virulence The degree of pathogenicity within a group or species of microorganisms or viruses as indicated by case fatality rates and/or the ability of the organism to invade the tissues of the host. The pathogenic capacity of an organism is determined by its VIRULENCE FACTORS. Pathogenicity

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