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An amino acid analyser method using ninhydrin was developed for (S)-alpha-fluoromethylhistidine (FMH) with a minimum quantitation limit of 0.2 microgram mL-1. The assay was used to study the kinetics of FMH in rat. After bolus intravenous administration of FMH hydrochloride hemihydrate (50 mg kg-1), plasma concentration decreased biexponentially with half-lives of 4.4 and 32.7 min. The distribution volumes of the central and peripheral compartments were 127.4 and 166.3 mL kg-1, respectively. The tissue concentration of FMH was highest in the kidney and also decreased biphasically. The FMH concentrations in other tissues were lower, but their tissue/plasma ratios of FMH increased continuously after FMH injection, indicating that FMH partitioned into these tissues and was lost from them very slowly.
E Sakurai, and
H Niwa, and
S Yamasaki, and
K Maeyama, and
T Watanabe
August 1985,
Journal of pharmaceutical sciences,
E Sakurai, and
H Niwa, and
S Yamasaki, and
K Maeyama, and
T Watanabe
September 1990,
Trends in pharmacological sciences,
E Sakurai, and
H Niwa, and
S Yamasaki, and
K Maeyama, and
T Watanabe
April 1984,
Biochemical pharmacology,
E Sakurai, and
H Niwa, and
S Yamasaki, and
K Maeyama, and
T Watanabe
October 1985,
Biochemical pharmacology,
E Sakurai, and
H Niwa, and
S Yamasaki, and
K Maeyama, and
T Watanabe
January 1984,
Progress in clinical and biological research,
E Sakurai, and
H Niwa, and
S Yamasaki, and
K Maeyama, and
T Watanabe
July 1982,
Biochemical pharmacology,
E Sakurai, and
H Niwa, and
S Yamasaki, and
K Maeyama, and
T Watanabe
August 1995,
Journal of neurochemistry,
E Sakurai, and
H Niwa, and
S Yamasaki, and
K Maeyama, and
T Watanabe
April 1990,
The Journal of biological chemistry,
E Sakurai, and
H Niwa, and
S Yamasaki, and
K Maeyama, and
T Watanabe
May 1991,
Agents and actions,
E Sakurai, and
H Niwa, and
S Yamasaki, and
K Maeyama, and
T Watanabe
March 1997,
Inflammation research : official journal of the European Histamine Research Society ... [et al.],
