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Male rats were given three different doses of ethanol in i.p. injections (0.66, 1.33 and 2.00 g kg-1). A dose-dependent decrease in the concentrations of most plasma amino acids was observed. For the total amino acid concentration this decrease was 5, 16 and 22%, respectively, compared with a saline-treated control group. It has previously been suggested that the oxidation of ethanol plays an important role in the amino acid decreasing effect of ethanol. In this study the lowest dose used (0.66 g kg-1) was calculated to be high enough to keep the enzyme systems involved in ethanol oxidation saturated during the 60 min course of the experiment. The observation that the ethanol-induced decrease in plasma amino acid levels was more pronounced with higher ethanol doses indicates that not only the oxidation of ethanol but also ethanol itself is important in the effect of ethanol on plasma amino acid concentrations.
M Hagman, and
T Eriksson
November 1986,
Biochemical pharmacology,
M Hagman, and
T Eriksson
January 1989,
Biochemical pharmacology,
M Hagman, and
T Eriksson
October 1986,
Biochemical medicine and metabolic biology,
M Hagman, and
T Eriksson
February 1975,
Biochemical pharmacology,
M Hagman, and
T Eriksson
January 1986,
The American journal of physiology,
M Hagman, and
T Eriksson
January 2001,
Alcohol (Fayetteville, N.Y.),
M Hagman, and
T Eriksson
October 1972,
Enzymologia,
M Hagman, and
T Eriksson
January 1954,
Hoppe-Seyler's Zeitschrift fur physiologische Chemie,
M Hagman, and
T Eriksson
January 1974,
Biochemical pharmacology,
M Hagman, and
T Eriksson
December 1995,
Biochimica et biophysica acta,
