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In three studies the effect and secondary effect of low molecular weight heparin (LMWH) were examined. Study 1: LMWH (Embolex-LM, n = 464) versus standard heparin (Liquemin, n = 452); Study 2: LMWH (Sandoparin, n = 298) versus standard heparin (n = 296). In the 3rd study controls of LMWH were performed in the clinic of visceral surgery, and the clinic of traumatology both. During these three studies all excluded patients who did not receive a thromboembolic prophylaxis were also examined. The first two studies showed no significant differences in the frequency of thromboembolic and bleeding complications. The bleeding complication was the same (3-6%) in the group of excluded patients. This is valid for study 3 too. In all studies the surgeon had an important influence on the frequency of bleeding complications.
R Hoffman, and
F Largiadèr, and
H P Brütsch
January 1989,
VASA. Supplementum,
R Hoffman, and
F Largiadèr, and
H P Brütsch
November 1987,
Deutsche medizinische Wochenschrift (1946),
R Hoffman, and
F Largiadèr, and
H P Brütsch
January 1987,
Geburtshilfe und Frauenheilkunde,
R Hoffman, and
F Largiadèr, and
H P Brütsch
August 2006,
Plastic and reconstructive surgery,
R Hoffman, and
F Largiadèr, and
H P Brütsch
September 2008,
Plastic and reconstructive surgery,
R Hoffman, and
F Largiadèr, and
H P Brütsch
October 1993,
The Annals of pharmacotherapy,
R Hoffman, and
F Largiadèr, and
H P Brütsch
January 1999,
Zeitschrift fur Orthopadie und ihre Grenzgebiete,
R Hoffman, and
F Largiadèr, and
H P Brütsch
January 1992,
Neurochirurgia,
R Hoffman, and
F Largiadèr, and
H P Brütsch
January 1992,
Langenbecks Archiv fur Chirurgie,
R Hoffman, and
F Largiadèr, and
H P Brütsch
October 1992,
BMJ (Clinical research ed.),
