-transparent.png){kind=logo}
This study was designed to investigate the possibility of a histamine mediation in muscular vasodilation induced by beta adrenoceptor stimulation. Accordingly, in seven dogs the effects of isoproterenol administration on the release of 14C-histamine from the perfused gracilis muscle were studied. Beta adrenoceptors stimulation induced a vasodilatation, as shown by a decrease in perfusion pressure(-43 +/- 12 mm Hg); simultaneously, a significant increase of the radioactivity measured in the venous blood effluent from the gracilis muscle was observed. Both these events were blocked by propranolol. In the other five dogs, chlorpheniramine was able to reduce the vasodilatation induced by the injection in the gracilis muscle of isoproterenol. Under control conditions, isoproterenol induced a fall in perfusion pressure of 44 +/- 5 mm Hg while, after chlorpheniramine, perfusion pressure decreased by only 24 +/- 4 mm Hg. The results of this study seem to confirm the possibility of a histamine mediation in isoproterenol-induced vasodilatation. However, further investigation is needed in order to identify the exact role of histamine in the geneis of this phenomenon.
F Rengo, and
B Trimarco, and
M Chiariello, and
M Volpe, and
B Ricciardelli, and
G Rasetti, and
L Sacca
January 1994,
The American journal of physiology,
F Rengo, and
B Trimarco, and
M Chiariello, and
M Volpe, and
B Ricciardelli, and
G Rasetti, and
L Sacca
September 1973,
Pflugers Archiv : European journal of physiology,
F Rengo, and
B Trimarco, and
M Chiariello, and
M Volpe, and
B Ricciardelli, and
G Rasetti, and
L Sacca
January 1973,
Comptes rendus des seances de la Societe de biologie et de ses filiales,
F Rengo, and
B Trimarco, and
M Chiariello, and
M Volpe, and
B Ricciardelli, and
G Rasetti, and
L Sacca
January 1989,
Archives internationales de pharmacodynamie et de therapie,
F Rengo, and
B Trimarco, and
M Chiariello, and
M Volpe, and
B Ricciardelli, and
G Rasetti, and
L Sacca
May 1977,
Experientia,
F Rengo, and
B Trimarco, and
M Chiariello, and
M Volpe, and
B Ricciardelli, and
G Rasetti, and
L Sacca
October 1983,
The Journal of pharmacology and experimental therapeutics,
F Rengo, and
B Trimarco, and
M Chiariello, and
M Volpe, and
B Ricciardelli, and
G Rasetti, and
L Sacca
August 2000,
Naunyn-Schmiedeberg's archives of pharmacology,
F Rengo, and
B Trimarco, and
M Chiariello, and
M Volpe, and
B Ricciardelli, and
G Rasetti, and
L Sacca
January 1988,
Archives internationales de pharmacodynamie et de therapie,
F Rengo, and
B Trimarco, and
M Chiariello, and
M Volpe, and
B Ricciardelli, and
G Rasetti, and
L Sacca
January 1978,
British journal of pharmacology,
F Rengo, and
B Trimarco, and
M Chiariello, and
M Volpe, and
B Ricciardelli, and
G Rasetti, and
L Sacca
July 1989,
The American journal of physiology,
