The TryPIKinome of five human pathogenic trypanosomatids: Trypanosoma brucei, Trypanosoma cruzi, Leishmania major, Leishmania braziliensis and Leishmania infantum--new tools for designing specific inhibitors. 2009

Diana Bahia, and Luciana Márcia Oliveira, and Fabio Mitsuo Lima, and Priscila Oliveira, and José Franco da Silveira, and Renato Arruda Mortara, and Jerônimo Conceição Ruiz
Escola Paulista de Medicina, UNIFESP, São Paulo, Brazil. dianabahia@hotmail.com

Phosphatidylinositol (PI) kinases are at the heart of one of the major pathways of intracellular signal transduction. Herein, we present the first report on a survey made by similarity searches against the five human pathogenic trypanosomatids Trypanosoma brucei, Trypanosoma cruzi, Leishmania major, Leishmania braziliensis and Leishmania infantum genomes available to date for phosphatidylinositol- and related-kinases (TryPIKs). In addition to generating a panel called "The TryPIKinome", we propose a model of signaling pathways for these TryPIKs. The involvement of TryPIKs in fundamental pathways, such as intracellular signal transduction and host invasion processes, makes the study of TryPIKs an important area for further inquiry. New subtype-specific inhibitors are expected to work on individual members of the PIK family and, therefore, can presumably neutralize trypanosomatid invasion processes.

UI MeSH Term Description Entries
D007892 Leishmania braziliensis A parasitic hemoflagellate of the subgenus Leishmania viannia that infects man and animals. It causes cutaneous (LEISHMANIASIS, CUTANEOUS), diffuse cutaneous (LEISHMANIASIS, DIFFUSE CUTANEOUS), and mucocutaneous leishmaniasis (LEISHMANIASIS, MUCOCUTANEOUS) depending on the subspecies of this organism. The sandfly, Lutzomyia, is the vector. The Leishmania braziliensis complex includes the subspecies braziliensis and peruviana. Uta, a form of cutaneous leishmaniasis in the New World, is caused by the subspecies peruviana. Leishmania (Viannia) braziliensis,Leishmania braziliensis braziliensis,Leishmania (Viannia) brasiliensis,Leishmania brasiliensis,Leishmania brasiliensis brasiliensis,Leishmania brasiliensis peruviana,Leishmania braziliensis peruviana,Leishmania viannia brasiliensis,Leishmania viannia braziliensis
D008239 Lysine An essential amino acid. It is often added to animal feed. Enisyl,L-Lysine,Lysine Acetate,Lysine Hydrochloride,Acetate, Lysine,L Lysine
D008969 Molecular Sequence Data Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories. Sequence Data, Molecular,Molecular Sequencing Data,Data, Molecular Sequence,Data, Molecular Sequencing,Sequencing Data, Molecular
D010802 Phylogeny The relationships of groups of organisms as reflected by their genetic makeup. Community Phylogenetics,Molecular Phylogenetics,Phylogenetic Analyses,Phylogenetic Analysis,Phylogenetic Clustering,Phylogenetic Comparative Analysis,Phylogenetic Comparative Methods,Phylogenetic Distance,Phylogenetic Generalized Least Squares,Phylogenetic Groups,Phylogenetic Incongruence,Phylogenetic Inference,Phylogenetic Networks,Phylogenetic Reconstruction,Phylogenetic Relatedness,Phylogenetic Relationships,Phylogenetic Signal,Phylogenetic Structure,Phylogenetic Tree,Phylogenetic Trees,Phylogenomics,Analyse, Phylogenetic,Analysis, Phylogenetic,Analysis, Phylogenetic Comparative,Clustering, Phylogenetic,Community Phylogenetic,Comparative Analysis, Phylogenetic,Comparative Method, Phylogenetic,Distance, Phylogenetic,Group, Phylogenetic,Incongruence, Phylogenetic,Inference, Phylogenetic,Method, Phylogenetic Comparative,Molecular Phylogenetic,Network, Phylogenetic,Phylogenetic Analyse,Phylogenetic Clusterings,Phylogenetic Comparative Analyses,Phylogenetic Comparative Method,Phylogenetic Distances,Phylogenetic Group,Phylogenetic Incongruences,Phylogenetic Inferences,Phylogenetic Network,Phylogenetic Reconstructions,Phylogenetic Relatednesses,Phylogenetic Relationship,Phylogenetic Signals,Phylogenetic Structures,Phylogenetic, Community,Phylogenetic, Molecular,Phylogenies,Phylogenomic,Reconstruction, Phylogenetic,Relatedness, Phylogenetic,Relationship, Phylogenetic,Signal, Phylogenetic,Structure, Phylogenetic,Tree, Phylogenetic
D002462 Cell Membrane The lipid- and protein-containing, selectively permeable membrane that surrounds the cytoplasm in prokaryotic and eukaryotic cells. Plasma Membrane,Cytoplasmic Membrane,Cell Membranes,Cytoplasmic Membranes,Membrane, Cell,Membrane, Cytoplasmic,Membrane, Plasma,Membranes, Cell,Membranes, Cytoplasmic,Membranes, Plasma,Plasma Membranes
D004791 Enzyme Inhibitors Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction. Enzyme Inhibitor,Inhibitor, Enzyme,Inhibitors, Enzyme
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000077191 Wortmannin An androstadiene metabolite produced by the fungi PENICILLIUM funiculosum that inhibits PHOSPHATIDYLINOSITOL-3-KINASES and alloantigen-specific activation of T-LYMPHOCYTES in human tumor cell lines. It is widely used in CELL BIOLOGY research and has broad therapeutic potential. MS 54,MS-54,MS54
D000595 Amino Acid Sequence The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION. Protein Structure, Primary,Amino Acid Sequences,Sequence, Amino Acid,Sequences, Amino Acid,Primary Protein Structure,Primary Protein Structures,Protein Structures, Primary,Structure, Primary Protein,Structures, Primary Protein
D000730 Androstadienes Derivatives of the steroid androstane having two double bonds at any site in any of the rings.

Related Publications

Diana Bahia, and Luciana Márcia Oliveira, and Fabio Mitsuo Lima, and Priscila Oliveira, and José Franco da Silveira, and Renato Arruda Mortara, and Jerônimo Conceição Ruiz
September 2005, BMC genomics,
Diana Bahia, and Luciana Márcia Oliveira, and Fabio Mitsuo Lima, and Priscila Oliveira, and José Franco da Silveira, and Renato Arruda Mortara, and Jerônimo Conceição Ruiz
June 2019, Journal of infection in developing countries,
Diana Bahia, and Luciana Márcia Oliveira, and Fabio Mitsuo Lima, and Priscila Oliveira, and José Franco da Silveira, and Renato Arruda Mortara, and Jerônimo Conceição Ruiz
August 2007, Eukaryotic cell,
Diana Bahia, and Luciana Márcia Oliveira, and Fabio Mitsuo Lima, and Priscila Oliveira, and José Franco da Silveira, and Renato Arruda Mortara, and Jerônimo Conceição Ruiz
October 2010, Journal of nucleic acids,
Diana Bahia, and Luciana Márcia Oliveira, and Fabio Mitsuo Lima, and Priscila Oliveira, and José Franco da Silveira, and Renato Arruda Mortara, and Jerônimo Conceição Ruiz
January 1995, The Journal of eukaryotic microbiology,
Diana Bahia, and Luciana Márcia Oliveira, and Fabio Mitsuo Lima, and Priscila Oliveira, and José Franco da Silveira, and Renato Arruda Mortara, and Jerônimo Conceição Ruiz
January 1992, Immunology letters,
Diana Bahia, and Luciana Márcia Oliveira, and Fabio Mitsuo Lima, and Priscila Oliveira, and José Franco da Silveira, and Renato Arruda Mortara, and Jerônimo Conceição Ruiz
January 2013, Methods in molecular biology (Clifton, N.J.),
Diana Bahia, and Luciana Márcia Oliveira, and Fabio Mitsuo Lima, and Priscila Oliveira, and José Franco da Silveira, and Renato Arruda Mortara, and Jerônimo Conceição Ruiz
January 1991, Revista da Sociedade Brasileira de Medicina Tropical,
Diana Bahia, and Luciana Márcia Oliveira, and Fabio Mitsuo Lima, and Priscila Oliveira, and José Franco da Silveira, and Renato Arruda Mortara, and Jerônimo Conceição Ruiz
March 2019, Molecules (Basel, Switzerland),
Diana Bahia, and Luciana Márcia Oliveira, and Fabio Mitsuo Lima, and Priscila Oliveira, and José Franco da Silveira, and Renato Arruda Mortara, and Jerônimo Conceição Ruiz
September 2000, The Journal of biological chemistry,
Copied contents to your clipboard!