OBJECTIVE The work presented herein rests on the study of the Varian EPID aS500-II and the Image Acquisition system IAS3. We assessed the dosimetric performance of this EPID for measurements and quality assurance of enhanced dynamic wedge profiles and wedge factors. METHODS We evaluated the dosimeter properties using the integrated asynchronous mode of acquisition in treatments with enhanced dynamic wedges (EDW). We studied the performance, stability and the reproducibility in measurements of the transmission factors and profiles of the fields with dynamic wedges. EPID profiles were compared to the "Profiler Sun Nuclear" diode array and PTW ion chamber. Analytical functions were developed in order to correct EDW profiles. The dependence of EPID measurements on wedge direction, beam dimensions and source to EPID distance was assessed. RESULTS The backscatter produced by the "exact arm" was evaluated; EPID profiles depended on the EDW direction and on the detector source distance. Wedge factors were determined using this detector and compared to the ion chamber response, differences were all within 1 %. Two empirical correction functions were developed to produce EPID wedge profiles that correspond to diode for all wedge angles and energies depending on the wedge direction. CONCLUSIONS The EPID is highly suited to regular measurement of EDW due to the reproducibility of the EPID-measured wedge factors and profiles.