BIOMAT Database Logo BIOMAT Database Logo

Testicular function after treatment for acute lymphoblastic leukemia (all) in prepubertal and pubertal boys. 2009

Maryna Krawczuk-Rybak, and Elzbieta Solarz, and Jolanta Wysocka, and Michal Matysiak, and Artur Gadomski, and Bernarda Kazanowska, and Dorota Sega-Pondel
Department of Pediatric Oncology and Hematology, Medical University, Bialystok, Poland. rybak@muwb.edu.pl

Testicular function was evaluated in 59 male (27 prepubertal and 32 pubertal) survivors treated for ALL according to two different protocols. Serum inhibin B, FSH, testosterone, LH, and testicular volume were measured. In both groups the mean values of inhibin B were lower than control, whereas the other analyzed parameters were comparable. The inhibin B-to-FSH ratio was reduced as compared to the control. Testicular volume was lower than in healthy pubertal patients. The results show that treatment for ALL has a negative effect on spermatogenesis, regardless of the age at treatment and type of therapy.

UI MeSH Term Description Entries
D007265 Inhibins Glycoproteins that inhibit pituitary FOLLICLE STIMULATING HORMONE secretion. Inhibins are secreted by the Sertoli cells of the testes, the granulosa cells of the ovarian follicles, the placenta, and other tissues. Inhibins and ACTIVINS are modulators of FOLLICLE STIMULATING HORMONE secretions; both groups belong to the TGF-beta superfamily, as the TRANSFORMING GROWTH FACTOR BETA. Inhibins consist of a disulfide-linked heterodimer with a unique alpha linked to either a beta A or a beta B subunit to form inhibin A or inhibin B, respectively Female Inhibin,Inhibin,Inhibin-F,Inhibins, Female,Inhibins, Testicular,Ovarian Inhibin,Testicular Inhibin,Female Inhibins,Inhibin F,Inhibin, Female,Inhibin, Ovarian,Inhibin, Testicular,Testicular Inhibins
D007986 Luteinizing Hormone A major gonadotropin secreted by the adenohypophysis (PITUITARY GLAND, ANTERIOR). Luteinizing hormone regulates steroid production by the interstitial cells of the TESTIS and the OVARY. The preovulatory LUTEINIZING HORMONE surge in females induces OVULATION, and subsequent LUTEINIZATION of the follicle. LUTEINIZING HORMONE consists of two noncovalently linked subunits, alpha and beta. Within a species, the alpha subunit is common in the three pituitary glycoprotein hormones (TSH, LH and FSH), but the beta subunit is unique and confers its biological specificity. ICSH (Interstitial Cell Stimulating Hormone),Interstitial Cell-Stimulating Hormone,LH (Luteinizing Hormone),Lutropin,Luteoziman,Luteozyman,Hormone, Interstitial Cell-Stimulating,Hormone, Luteinizing,Interstitial Cell Stimulating Hormone
D008297 Male Males
D011241 Prednisone A synthetic anti-inflammatory glucocorticoid derived from CORTISONE. It is biologically inert and converted to PREDNISOLONE in the liver. Dehydrocortisone,delta-Cortisone,Apo-Prednisone,Cortan,Cortancyl,Cutason,Dacortin,Decortin,Decortisyl,Deltasone,Encorton,Encortone,Enkortolon,Kortancyl,Liquid Pred,Meticorten,Orasone,Panafcort,Panasol,Predni Tablinen,Prednidib,Predniment,Prednison Acsis,Prednison Galen,Prednison Hexal,Pronisone,Rectodelt,Sone,Sterapred,Ultracorten,Winpred,Acsis, Prednison
D002648 Child A person 6 to 12 years of age. An individual 2 to 5 years old is CHILD, PRESCHOOL. Children
D002675 Child, Preschool A child between the ages of 2 and 5. Children, Preschool,Preschool Child,Preschool Children
D003630 Daunorubicin A very toxic anthracycline aminoglycoside antineoplastic isolated from Streptomyces peucetius and others, used in treatment of LEUKEMIA and other NEOPLASMS. Daunomycin,Rubidomycin,Rubomycin,Cerubidine,Dauno-Rubidomycine,Daunoblastin,Daunoblastine,Daunorubicin Hydrochloride,NSC-82151,Dauno Rubidomycine,Hydrochloride, Daunorubicin,NSC 82151,NSC82151
D005640 Follicle Stimulating Hormone A major gonadotropin secreted by the adenohypophysis (PITUITARY GLAND, ANTERIOR). Follicle-stimulating hormone stimulates GAMETOGENESIS and the supporting cells such as the ovarian GRANULOSA CELLS, the testicular SERTOLI CELLS, and LEYDIG CELLS. FSH consists of two noncovalently linked subunits, alpha and beta. Within a species, the alpha subunit is common in the three pituitary glycoprotein hormones (TSH, LH, and FSH), but the beta subunit is unique and confers its biological specificity. FSH (Follicle Stimulating Hormone),Follicle-Stimulating Hormone,Follitropin
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000293 Adolescent A person 13 to 18 years of age. Adolescence,Youth,Adolescents,Adolescents, Female,Adolescents, Male,Teenagers,Teens,Adolescent, Female,Adolescent, Male,Female Adolescent,Female Adolescents,Male Adolescent,Male Adolescents,Teen,Teenager,Youths

Related Publications

Maryna Krawczuk-Rybak, and Elzbieta Solarz, and Jolanta Wysocka, and Michal Matysiak, and Artur Gadomski, and Bernarda Kazanowska, and Dorota Sega-Pondel
Testicular function in boys after chemotherapy for acute lymphoblastic leukemia.
May 1981, The New England journal of medicine,
Maryna Krawczuk-Rybak, and Elzbieta Solarz, and Jolanta Wysocka, and Michal Matysiak, and Artur Gadomski, and Bernarda Kazanowska, and Dorota Sega-Pondel
Hypothalamo-hypophyseal-testicular function in prepubertal boys with acute lymphoblastic leukemia following chemotherapy and testicular radiotherapy.
May 1984, Acta paediatrica Scandinavica,
Maryna Krawczuk-Rybak, and Elzbieta Solarz, and Jolanta Wysocka, and Michal Matysiak, and Artur Gadomski, and Bernarda Kazanowska, and Dorota Sega-Pondel
Leydig cell function in boys following treatment for testicular relapse of acute lymphoblastic leukemia.
September 1985, Journal of clinical oncology : official journal of the American Society of Clinical Oncology,
Maryna Krawczuk-Rybak, and Elzbieta Solarz, and Jolanta Wysocka, and Michal Matysiak, and Artur Gadomski, and Bernarda Kazanowska, and Dorota Sega-Pondel
Testicular function after chemotherapy for acute lymphoblastic leukemia.
August 1981, The New England journal of medicine,
Maryna Krawczuk-Rybak, and Elzbieta Solarz, and Jolanta Wysocka, and Michal Matysiak, and Artur Gadomski, and Bernarda Kazanowska, and Dorota Sega-Pondel
[Testicular function after chemotherapy for acute lymphoblastic leukemia].
October 1981, South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde,
Maryna Krawczuk-Rybak, and Elzbieta Solarz, and Jolanta Wysocka, and Michal Matysiak, and Artur Gadomski, and Bernarda Kazanowska, and Dorota Sega-Pondel
[Leukemic testicular infiltrates in boys with acute lymphoblastic leukemia (ALL) (author's transl)].
January 1982, Medicina clinica,
Maryna Krawczuk-Rybak, and Elzbieta Solarz, and Jolanta Wysocka, and Michal Matysiak, and Artur Gadomski, and Bernarda Kazanowska, and Dorota Sega-Pondel
Gonadal function after testicular radiation for acute lymphoblastic leukemia.
June 1986, Archives of disease in childhood,
Maryna Krawczuk-Rybak, and Elzbieta Solarz, and Jolanta Wysocka, and Michal Matysiak, and Artur Gadomski, and Bernarda Kazanowska, and Dorota Sega-Pondel
The effect of testicular irradiation on Leydig cell function in prepubertal boys with acute lymphoblastic leukaemia.
November 1983, Archives of disease in childhood,
Maryna Krawczuk-Rybak, and Elzbieta Solarz, and Jolanta Wysocka, and Michal Matysiak, and Artur Gadomski, and Bernarda Kazanowska, and Dorota Sega-Pondel
Testicular relapse of acute lymphoblastic leukemia (ALL).
August 1990, Journal of reproductive immunology,
Maryna Krawczuk-Rybak, and Elzbieta Solarz, and Jolanta Wysocka, and Michal Matysiak, and Artur Gadomski, and Bernarda Kazanowska, and Dorota Sega-Pondel
[The influence of chemotherapy on testicular function of boys with acute lymphoblastic leukemia].
August 1990, Nihon Hinyokika Gakkai zasshi. The japanese journal of urology,
Copied contents to your clipboard!