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In seven patients with factitious hypoglycemia due to the surreptitious injection of insulin, we made the diagnosis by measurements of plasma insulin and C-peptide immunoreactivity (in seven patients), facilitated by the finding of circulating insulin-binding antibodies (in two patients). The simultaneous demonstration of low plasma glucose, high immunoreactive insulin and suppressed C-peptide immunoreactivity represents a triad of results pathognomonic of exogenous insulin administration. Determination of plasma free C-peptide and free insulin permitted patients with high titers of insulin antibodies, including those with a history of insulin-treated diabetes, to be studied and diagnosed in a way similar to that in subjects who had no circulating insulin antibodies.
J A Scarlett, and
M E Mako, and
A H Rubenstein, and
P M Blix, and
J Goldman, and
D L Horwitz, and
H Tager, and
J B Jaspan, and
M R Stjernholm, and
J M Olefsky
January 1980,
Acta diabetologica latina,
J A Scarlett, and
M E Mako, and
A H Rubenstein, and
P M Blix, and
J Goldman, and
D L Horwitz, and
H Tager, and
J B Jaspan, and
M R Stjernholm, and
J M Olefsky
July 1980,
American journal of clinical pathology,
J A Scarlett, and
M E Mako, and
A H Rubenstein, and
P M Blix, and
J Goldman, and
D L Horwitz, and
H Tager, and
J B Jaspan, and
M R Stjernholm, and
J M Olefsky
January 1983,
Diabetes care,
J A Scarlett, and
M E Mako, and
A H Rubenstein, and
P M Blix, and
J Goldman, and
D L Horwitz, and
H Tager, and
J B Jaspan, and
M R Stjernholm, and
J M Olefsky
February 1975,
Annals of internal medicine,
J A Scarlett, and
M E Mako, and
A H Rubenstein, and
P M Blix, and
J Goldman, and
D L Horwitz, and
H Tager, and
J B Jaspan, and
M R Stjernholm, and
J M Olefsky
October 1969,
Mayo Clinic proceedings,
J A Scarlett, and
M E Mako, and
A H Rubenstein, and
P M Blix, and
J Goldman, and
D L Horwitz, and
H Tager, and
J B Jaspan, and
M R Stjernholm, and
J M Olefsky
January 1975,
Verhandlungen der Deutschen Gesellschaft fur Innere Medizin,
J A Scarlett, and
M E Mako, and
A H Rubenstein, and
P M Blix, and
J Goldman, and
D L Horwitz, and
H Tager, and
J B Jaspan, and
M R Stjernholm, and
J M Olefsky
December 2014,
Journal of clinical research in pediatric endocrinology,
J A Scarlett, and
M E Mako, and
A H Rubenstein, and
P M Blix, and
J Goldman, and
D L Horwitz, and
H Tager, and
J B Jaspan, and
M R Stjernholm, and
J M Olefsky
May 1960,
The New England journal of medicine,
J A Scarlett, and
M E Mako, and
A H Rubenstein, and
P M Blix, and
J Goldman, and
D L Horwitz, and
H Tager, and
J B Jaspan, and
M R Stjernholm, and
J M Olefsky
December 1987,
Journal of endocrinological investigation,
J A Scarlett, and
M E Mako, and
A H Rubenstein, and
P M Blix, and
J Goldman, and
D L Horwitz, and
H Tager, and
J B Jaspan, and
M R Stjernholm, and
J M Olefsky
December 1978,
Medical journal of Osaka University,
