-transparent.png){kind=logo}
It has been reported that src family protein-tyrosine kinases were expressed specifically in a certain lineage or differentiation stage of hematopoietic cells. To understand the molecular basis for differentiation and function of monocyte/macrophage, we investigated the expressions of src family genes by the HL-60 cells stimulated with differentiation-inducing agents. TPA and vitamin D3 (D3) were used as stimulants for monocytic development, since each agent has been known to induce phenotypically specific differentiation of HL-60 cells. The fyn, fgr, and lyn genes were characteristically expressed concomitantly with phenotypic changes and expressions of nuclear proto-oncogenes, whereas src, lck, hck, and yes genes were not. In TPA-induced differentiation of HL-60 cells, both fyn and lyn genes, but not fgr gene, were expressed. In contrast, both fgr and lyn genes, but not fyn gene, were expressed in D3-induced differentiation of the cells. The independent and characteristic expressions of these genes were observed in the further advanced differentiation of HL-60 cells induced by TPA plus D3 or D3 plus human transforming growth factor-beta 1. The granulocytic differentiation of the cells treated with retinoic acid was accompanied by intense expression of fgr, but weak or no expression of lyn and fyn gene. These data indicate that each protein-tyrosine kinase encoded by src family genes may play distinct roles in development and/or functions of monocyte/macrophage-lineage cells.
K Katagiri, and
T Katagiri, and
Y Koyama, and
M Morikawa, and
T Yamamoto, and
T Yoshida
March 2009,
Free radical biology & medicine,
K Katagiri, and
T Katagiri, and
Y Koyama, and
M Morikawa, and
T Yamamoto, and
T Yoshida
August 2007,
Toxicology in vitro : an international journal published in association with BIBRA,
K Katagiri, and
T Katagiri, and
Y Koyama, and
M Morikawa, and
T Yamamoto, and
T Yoshida
June 1983,
Experimental cell research,
K Katagiri, and
T Katagiri, and
Y Koyama, and
M Morikawa, and
T Yamamoto, and
T Yoshida
June 2012,
Leukemia & lymphoma,
K Katagiri, and
T Katagiri, and
Y Koyama, and
M Morikawa, and
T Yamamoto, and
T Yoshida
April 2003,
Experimental & molecular medicine,
K Katagiri, and
T Katagiri, and
Y Koyama, and
M Morikawa, and
T Yamamoto, and
T Yoshida
May 1999,
The Journal of biological chemistry,
K Katagiri, and
T Katagiri, and
Y Koyama, and
M Morikawa, and
T Yamamoto, and
T Yoshida
December 2018,
Leukemia & lymphoma,
K Katagiri, and
T Katagiri, and
Y Koyama, and
M Morikawa, and
T Yamamoto, and
T Yoshida
January 1987,
Experimental cell research,
K Katagiri, and
T Katagiri, and
Y Koyama, and
M Morikawa, and
T Yamamoto, and
T Yoshida
February 1995,
Experimental cell research,
K Katagiri, and
T Katagiri, and
Y Koyama, and
M Morikawa, and
T Yamamoto, and
T Yoshida
August 2014,
Immunobiology,
