BIOMAT Database Logo BIOMAT Database Logo

Enhanced OECD TG 407 in detection of endocrine-mediated effects of 4,4'-(octahydro-4,7-methano-5H-inden-5-ylidene)bisphenol. 2010

Takaaki Umano, and Katsumi Miyata, and Yasushi Minobe, and Kanji Yamasaki
Chemicals Evaluation and Research Institute, 1-4-25 Kouraku, Bunkyo-ku, Tokyo 112-0004, Japan. umano-takaaki@ceri.jp

The purpose of this study was to investigate whether the estrogenic effects were detected in the enhanced TG 407 if the estrogenic property was not so strong in the uterotrophic assay. The estrogenic property of 4,4'-(octahydro-4,7-methano-5H-inden-5-ylidene)bisphenol in the uterotrophic assay was slightly stronger than that of genistein or nonylphenol, but weaker than that of ethinyl estradiol. We performed a 28-day repeated-dose toxicity study (enhanced OECD test guideline No. 407) on 4,4'-(octahydro-4,7-methano-5H-inden-5-ylidene)bisphenol based on the OECD draft protocol. The test chemical, administered orally at doses of 0, 10, 50, and 250 mg/kg per day for at least 28 days, caused such estrogenic effects as abnormal estrous cycle, increased ovarian follicles, increased uterine epithelial height, and vaginal mucification in the 50 and/or 250 mg/kg groups. Moreover, follicular epithelial cell hyperplasia of the thyroid was detected in all male rats given the test chemical and in female rats in the 250 mg/kg group. It was concluded that the estrogenic effects were detected in growing rats given 4,4'-(octahydro-4,7-methano-5H-inden-5-ylidene)bisphenol, and thyroid dysfunction was also observed as the endocrine-mediated effects.

UI MeSH Term Description Entries
D007390 International Agencies International organizations which provide health-related or other cooperative services. Agencies, International,Agency, International,International Agency
D008297 Male Males
D009929 Organ Size The measurement of an organ in volume, mass, or heaviness. Organ Volume,Organ Weight,Size, Organ,Weight, Organ
D001835 Body Weight The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms. Body Weights,Weight, Body,Weights, Body
D005062 European Union An economic union with the principal objectives of free movement of goods, capital, and labor. The constituent countries are Austria, Belgium, Bulgaria, Croatia, Cyprus, Czech Republic, Denmark, Estonia, Finland, France, Germany, Greece, Hungary, Ireland, Italy, Latvia, Lithuania, Luxembourg, Malta, Netherlands, Poland, Portugal, Romania, Slovakia, Slovenia, Spain, and Sweden. (https://europa.eu/european-union/about-eu/countries accessed 12/31/2020) Common Market,Euratom,European Atomic Energy Community,European Coal and Steel Community,European Common Market,European Community,European Economic Community,Community, European Economic,EEC,Economic Community, European,Common Market, European,Common Markets,Common Markets, European,Communities, European,Communities, European Economic,Community, European,Economic Communities, European,European Common Markets,European Communities,European Economic Communities,Market, Common,Market, European Common,Union, European
D005260 Female Females
D005836 Genitalia, Female The female reproductive organs. The external organs include the VULVA; BARTHOLIN'S GLANDS; and CLITORIS. The internal organs include the VAGINA; UTERUS; OVARY; and FALLOPIAN TUBES. Accessory Sex Organs, Female,Sex Organs, Accessory, Female,Genital Organs, Female,Genitals, Female,Reproductive System, Female,Female Genital,Female Genital Organ,Female Genital Organs,Female Genitalia,Female Genitals,Female Reproductive System,Female Reproductive Systems,Genital Organ, Female,Genital, Female,Reproductive Systems, Female
D005837 Genitalia, Male The male reproductive organs. They are divided into the external organs (PENIS; SCROTUM; and URETHRA) and the internal organs (TESTIS; EPIDIDYMIS; VAS DEFERENS; SEMINAL VESICLES; EJACULATORY DUCTS; PROSTATE; and BULBOURETHRAL GLANDS). Accessory Sex Organs, Male,Genital Organs, Male,Sex Organs, Accessory, Male,Genitals, Male,Reproductive System, Male,Genital, Male,Male Genital,Male Genital Organs,Male Genitalia,Male Genitals,Male Reproductive System,Male Reproductive Systems,Reproductive Systems, Male
D006403 Hematologic Tests Tests used in the analysis of the hemic system. Blood Tests,Hematologic Test,Hematological Tests,Test, Hematologic,Tests, Hematologic,Blood Test,Hematological Test,Test, Blood,Test, Hematological,Tests, Blood,Tests, Hematological
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia

Related Publications

Takaaki Umano, and Katsumi Miyata, and Yasushi Minobe, and Kanji Yamasaki
Endocrine disruption of cadmium in rats using the OECD enhanced TG 407 test system.
December 2014, Biomedical and environmental sciences : BES,
Takaaki Umano, and Katsumi Miyata, and Yasushi Minobe, and Kanji Yamasaki
RIFM fragrance ingredient safety assessment, octahydro-4,7-methano-1h-indene-5-ol, CAS Registry Number 13380-89-7.
December 2018, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association,
Takaaki Umano, and Katsumi Miyata, and Yasushi Minobe, and Kanji Yamasaki
RIFM fragrance ingredient safety assessment, 4,7-methano-1H-inden-5-ol, 3a,4,5,6,7,7a-hexahydrodimethyl-, CAS Registry Number 79771-15-6.
January 2022, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association,
Takaaki Umano, and Katsumi Miyata, and Yasushi Minobe, and Kanji Yamasaki
RIFM fragrance ingredient safety assessment, decahydrospiro[furan-2(3H),5'-[4,7]methano[5H]indene], CAS Registry Number 68480-11-5.
April 2020, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association,
Takaaki Umano, and Katsumi Miyata, and Yasushi Minobe, and Kanji Yamasaki
RIFM fragrance ingredient safety assessment, 3a,4,5,6,7,7a-hexahydro-4,7-methano-1H-inden-5-yl isobutyrate, CAS registry number 67634-20-2.
December 2018, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association,
Takaaki Umano, and Katsumi Miyata, and Yasushi Minobe, and Kanji Yamasaki
Detection of endocrine-modulating effects of the antithyroid acting drug 6-propyl-2-thiouracil in rats, based on the "Enhanced OECD Test Guideline 407".
December 2003, Regulatory toxicology and pharmacology : RTP,
Takaaki Umano, and Katsumi Miyata, and Yasushi Minobe, and Kanji Yamasaki
Effects of citrate ester plasticizers and bis (2-ethylhexyl) phthalate in the OECD 28-day repeated-dose toxicity test (OECD TG 407).
May 2019, Environmental research,
Takaaki Umano, and Katsumi Miyata, and Yasushi Minobe, and Kanji Yamasaki
(3-Methyl-3a,4,7,7a-tetra-hydro-5H-4,7-methano-isoxazolo[4,5-d][1,2]oxazin-5-yl)(phen-yl)methanone.
May 2014, Acta crystallographica. Section E, Structure reports online,
Takaaki Umano, and Katsumi Miyata, and Yasushi Minobe, and Kanji Yamasaki
Sensitive detection of the endocrine effects of the estrogen analogue ethinylestradiol using a modified enhanced subacute rat study protocol (OECD Test Guideline no. 407).
May 2002, Archives of toxicology,
Takaaki Umano, and Katsumi Miyata, and Yasushi Minobe, and Kanji Yamasaki
The enhancement of the subacute repeat dose toxicity test OECD TG 407 for the detection of endocrine active chemicals: comparison with toxicity tests of longer duration.
April 2007, Archives of toxicology,
Copied contents to your clipboard!