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A retrospective review of 578 patients with invasive cervical cancer identified 8 patients with a history of one or more cone biopsies for treatment of cervical intraepithelial neoplasia. The cone biopsy and hysterectomy specimens were reviewed to identify factors predictive of the subsequent development of invasive cancer. The mean interval from cone biopsy to diagnosis of invasive carcinoma was 6.7 years (range 1.5-16.5 years). High-grade intraepithelial neoplasia is a potentially invasive lesion. Adenocarcinoma in situ was identified as a high-risk lesion that may be inadequately treated by cone biopsy. Four patients developed invasive squamous cancer in spite of complete excision of the initial lesion. Patients who have high-grade intraepithelial neoplasia treated with cone biopsy require long-term follow-up, and conization may hamper the subsequent diagnosis of preinvasive lesions.
J V Brown, and
W A Peters, and
D J Corwin
December 1983,
Clinical obstetrics and gynecology,
J V Brown, and
W A Peters, and
D J Corwin
August 1980,
American journal of obstetrics and gynecology,
J V Brown, and
W A Peters, and
D J Corwin
June 1997,
Lancet (London, England),
J V Brown, and
W A Peters, and
D J Corwin
June 1997,
Lancet (London, England),
J V Brown, and
W A Peters, and
D J Corwin
June 1997,
Lancet (London, England),
J V Brown, and
W A Peters, and
D J Corwin
April 1997,
Lancet (London, England),
J V Brown, and
W A Peters, and
D J Corwin
March 1995,
Bailliere's clinical obstetrics and gynaecology,
J V Brown, and
W A Peters, and
D J Corwin
December 1983,
Clinical obstetrics and gynecology,
J V Brown, and
W A Peters, and
D J Corwin
September 1998,
Annals of the Academy of Medicine, Singapore,
J V Brown, and
W A Peters, and
D J Corwin
January 1989,
CA: a cancer journal for clinicians,
