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The haemolysin from a virulent strain of Treponema hyodysenteriae was extracted and injected into ligated loops of the ileum and colon of germ-free pigs. It caused severe epithelial damage, especially to the differentiated cells at the tips of the villi in the ileum and the cells in the intercrypt zones of the colon; goblet cells were less affected. The changes in the colon were similar to those seen in natural cases of swine dysentery. The ligated loop offers a means of investigating pathogenic mechanisms and the mode of action of the toxin. This study demonstrated that the haemolysin was a potent cytotoxin for pig enterocytes, and a probable virulence determinant in swine dysentery.
R J Lysons, and
K A Kent, and
A P Bland, and
R Sellwood, and
W F Robinson, and
A J Frost
July 1975,
American journal of veterinary research,
R J Lysons, and
K A Kent, and
A P Bland, and
R Sellwood, and
W F Robinson, and
A J Frost
September 1983,
DTW. Deutsche tierarztliche Wochenschrift,
R J Lysons, and
K A Kent, and
A P Bland, and
R Sellwood, and
W F Robinson, and
A J Frost
June 1974,
American journal of veterinary research,
R J Lysons, and
K A Kent, and
A P Bland, and
R Sellwood, and
W F Robinson, and
A J Frost
November 1987,
Research in veterinary science,
R J Lysons, and
K A Kent, and
A P Bland, and
R Sellwood, and
W F Robinson, and
A J Frost
May 1982,
Journal of medical microbiology,
R J Lysons, and
K A Kent, and
A P Bland, and
R Sellwood, and
W F Robinson, and
A J Frost
October 1981,
Canadian journal of comparative medicine : Revue canadienne de medecine comparee,
R J Lysons, and
K A Kent, and
A P Bland, and
R Sellwood, and
W F Robinson, and
A J Frost
October 1990,
Infection and immunity,
R J Lysons, and
K A Kent, and
A P Bland, and
R Sellwood, and
W F Robinson, and
A J Frost
January 1976,
The Veterinary record,
R J Lysons, and
K A Kent, and
A P Bland, and
R Sellwood, and
W F Robinson, and
A J Frost
January 1975,
Acta veterinaria Scandinavica,
R J Lysons, and
K A Kent, and
A P Bland, and
R Sellwood, and
W F Robinson, and
A J Frost
April 1993,
Veterinary microbiology,
