BIOMAT Database Logo BIOMAT Database Logo

Cardiac contractility during hemofiltration in an awake model of hyperdynamic endotoxemia. 2009

Satoshi Ishihara, and John A Ward, and Osamu Tasaki, and Basil A Pruitt, and David W Mozingo
Department of Acute Medicine (S.I.), Kawasaki Medical School, Okayama, Japan. ishihara@med.kawasaki-m.ac.jp

BACKGROUND To determine whether continuous veno-venous hemofiltration can ameliorate hemodynamic instability and left ventricular (LV) dysfunction by reducing circulating plasma mediators, the authors used the LV end-systolic elastance (Ees) as a contractility index, in an awake swine model simulating human hyperdynamic endotoxemia. METHODS Nineteen instrumented pigs were divided into a control group (CTRL, n = 7), a hemofiltration (HF, n = 7) group, and an extracorporeal circuit (ECC, n = 5) only group. All animals received intravenous E. coli endotoxin (10 microg x kg x h) and resuscitation in a common regimen for 24 hours. Hemofiltration was started 30 minutes after initiation of endotoxemia and continued until the end of the experiment. RESULTS : Ees was maintained at baseline levels in the HF group, whereas a progressive decrease of Ees was found in both the CTRL and the ECC groups. Cardiac output was significantly higher in the HF group than the CTRL group. There was no significant difference between the groups in plasma catecholamines. CONCLUSIONS We conclude that hemofiltration prevented LV impairment.

UI MeSH Term Description Entries
D009200 Myocardial Contraction Contractile activity of the MYOCARDIUM. Heart Contractility,Inotropism, Cardiac,Cardiac Inotropism,Cardiac Inotropisms,Contractilities, Heart,Contractility, Heart,Contraction, Myocardial,Contractions, Myocardial,Heart Contractilities,Inotropisms, Cardiac,Myocardial Contractions
D001794 Blood Pressure PRESSURE of the BLOOD on the ARTERIES and other BLOOD VESSELS. Systolic Pressure,Diastolic Pressure,Pulse Pressure,Pressure, Blood,Pressure, Diastolic,Pressure, Pulse,Pressure, Systolic,Pressures, Systolic
D002302 Cardiac Output The volume of BLOOD passing through the HEART per unit of time. It is usually expressed as liters (volume) per minute so as not to be confused with STROKE VOLUME (volume per beat). Cardiac Outputs,Output, Cardiac,Outputs, Cardiac
D003243 Consciousness Sense of awareness of self and of the environment. Consciousnesses
D004195 Disease Models, Animal Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases. Animal Disease Model,Animal Disease Models,Disease Model, Animal
D004927 Escherichia coli Infections Infections with bacteria of the species ESCHERICHIA COLI. E coli Infections,E. coli Infection,Infections, E coli,Infections, Escherichia coli,E coli Infection,E. coli Infections,Escherichia coli Infection,Infection, E coli,Infection, E. coli,Infection, Escherichia coli
D005260 Female Females
D006339 Heart Rate The number of times the HEART VENTRICLES contract per unit of time, usually per minute. Cardiac Rate,Chronotropism, Cardiac,Heart Rate Control,Heartbeat,Pulse Rate,Cardiac Chronotropy,Cardiac Chronotropism,Cardiac Rates,Chronotropy, Cardiac,Control, Heart Rate,Heart Rates,Heartbeats,Pulse Rates,Rate Control, Heart,Rate, Cardiac,Rate, Heart,Rate, Pulse
D006439 Hemodynamics The movement and the forces involved in the movement of the blood through the CARDIOVASCULAR SYSTEM. Hemodynamic
D006440 Hemofiltration Extracorporeal ULTRAFILTRATION technique without HEMODIALYSIS for treatment of fluid overload and electrolyte disturbances affecting renal, cardiac, or pulmonary function. Arteriovenous Hemofiltration,Venovenous Hemofiltration,Arteriovenous Hemofiltrations,Hemofiltration, Arteriovenous,Hemofiltration, Venovenous,Hemofiltrations,Venovenous Hemofiltrations

Related Publications

Satoshi Ishihara, and John A Ward, and Osamu Tasaki, and Basil A Pruitt, and David W Mozingo
An Ovine Model of Hyperdynamic Endotoxemia and Vital Organ Metabolism.
January 2018, Shock (Augusta, Ga.),
Satoshi Ishihara, and John A Ward, and Osamu Tasaki, and Basil A Pruitt, and David W Mozingo
ATP-MgCl(2) during hyperdynamic porcine endotoxemia*.
August 2002, Critical care medicine,
Satoshi Ishihara, and John A Ward, and Osamu Tasaki, and Basil A Pruitt, and David W Mozingo
Efficacy of an extracorporeal endotoxin adsorber system during hyperdynamic porcine endotoxemia.
January 2009, European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes,
Satoshi Ishihara, and John A Ward, and Osamu Tasaki, and Basil A Pruitt, and David W Mozingo
Continuous hemofiltration in pigs with hyperdynamic septic shock affects cardiac repolarization.
December 2008, Critical care medicine,
Satoshi Ishihara, and John A Ward, and Osamu Tasaki, and Basil A Pruitt, and David W Mozingo
Myocardial depression in hyperdynamic endotoxemia.
October 1988, Circulatory shock,
Satoshi Ishihara, and John A Ward, and Osamu Tasaki, and Basil A Pruitt, and David W Mozingo
Effects of gram negative endotoxemia on myocardial contractility in the awake primate.
December 1973, Annals of surgery,
Satoshi Ishihara, and John A Ward, and Osamu Tasaki, and Basil A Pruitt, and David W Mozingo
The role of histamine in the increased cardiac output in hyperdynamic endotoxemia.
February 1994, Shock (Augusta, Ga.),
Satoshi Ishihara, and John A Ward, and Osamu Tasaki, and Basil A Pruitt, and David W Mozingo
Expression of adhesion molecules on circulating PMN during hyperdynamic endotoxemia.
July 1996, Journal of applied physiology (Bethesda, Md. : 1985),
Satoshi Ishihara, and John A Ward, and Osamu Tasaki, and Basil A Pruitt, and David W Mozingo
Cardiac function in an ovine model of endotoxemia.
September 1991, Circulatory shock,
Satoshi Ishihara, and John A Ward, and Osamu Tasaki, and Basil A Pruitt, and David W Mozingo
Mitochondrial bioenergetics links inflammation and cardiac contractility in endotoxemia.
August 2019, Basic research in cardiology,
Copied contents to your clipboard!