-transparent.png){kind=logo}
We investigated the role of platelet-activating factor (PAF) in acute septic lung injury by examining the effects of the selective PAF antagonist SRI 63-675 and by measuring PAF in lung tissue in the porcine model. Four groups of pigs (15-25 kg) were studied: saline control (C, n = 5); Pseudomonas (Ps, n = 9), given 5 x 10(8) CFU/ml at 0.3 ml/20 kg/min intravenously over 1 hr; SRI (n = 3), given SRI 63-675 in a 40 mg/kg bolus; and SRI + Ps (n = 5). Ps infusion produced a fulminant lung injury characterized by a threefold increase in pulmonary arterial pressure at 30 min and persistent pulmonary hypertension (P less than 0.05 vs C), a significant (P less than 0.05 vs C) decrease in arterial oxygen tension (PaO2) from 60 min, a significant (P less than 0.05 vs C) increase in extravascular lung water (EVLW) from 120 min, and a significant (P less than 0.05 vs C) increase in albumin flux determined scintigraphically as slope index at 150-180 min. Systemic arterial pressure and cardiac index (CI) decreased significantly (P less than 0.05) in the Ps group vs C at 60 and 180 min, respectively. Bolus injection of SRI 63-675 at the time of Ps infusion blocked the early pulmonary hypertension, attenuated the early and late fall in PaO2, ameliorated the increase in EVLW, and prevented the late (150-180 min) increase in albumin flux. SRI 63-675 had minimal effects on Ps-induced hypotension or alterations in CI.(ABSTRACT TRUNCATED AT 250 WORDS)
K Byrne, and
C N Sessler, and
P D Carey, and
T D Sielaff, and
A Vasquez, and
J L Tatum, and
J I Hirsch, and
H J Sugerman
November 1994,
Circulatory shock,
K Byrne, and
C N Sessler, and
P D Carey, and
T D Sielaff, and
A Vasquez, and
J L Tatum, and
J I Hirsch, and
H J Sugerman
July 2007,
Critical care medicine,
K Byrne, and
C N Sessler, and
P D Carey, and
T D Sielaff, and
A Vasquez, and
J L Tatum, and
J I Hirsch, and
H J Sugerman
July 2007,
Prostaglandins, leukotrienes, and essential fatty acids,
K Byrne, and
C N Sessler, and
P D Carey, and
T D Sielaff, and
A Vasquez, and
J L Tatum, and
J I Hirsch, and
H J Sugerman
August 2000,
The Annals of thoracic surgery,
K Byrne, and
C N Sessler, and
P D Carey, and
T D Sielaff, and
A Vasquez, and
J L Tatum, and
J I Hirsch, and
H J Sugerman
April 1992,
The American journal of pathology,
K Byrne, and
C N Sessler, and
P D Carey, and
T D Sielaff, and
A Vasquez, and
J L Tatum, and
J I Hirsch, and
H J Sugerman
January 1999,
Digestive surgery,
K Byrne, and
C N Sessler, and
P D Carey, and
T D Sielaff, and
A Vasquez, and
J L Tatum, and
J I Hirsch, and
H J Sugerman
February 1995,
The Annals of thoracic surgery,
K Byrne, and
C N Sessler, and
P D Carey, and
T D Sielaff, and
A Vasquez, and
J L Tatum, and
J I Hirsch, and
H J Sugerman
March 2023,
bioRxiv : the preprint server for biology,
K Byrne, and
C N Sessler, and
P D Carey, and
T D Sielaff, and
A Vasquez, and
J L Tatum, and
J I Hirsch, and
H J Sugerman
March 1994,
The American journal of physiology,
K Byrne, and
C N Sessler, and
P D Carey, and
T D Sielaff, and
A Vasquez, and
J L Tatum, and
J I Hirsch, and
H J Sugerman
September 1992,
Journal of immunology (Baltimore, Md. : 1950),
