Biomaterial Database

Significance of the endothelial lining in prevention of intimal thickening of autogenous vein grafts in dogs. 1991

H Eguchi, and K Okadome, and S Mii, and T Yukizane, and K Sugimachi

Second Department of Surgery, Faculty of Medicine, Kyushu University, Fukuoka, Japan.

To better comprehend the role of the endothelial lining in occurrence and development of intimal thickening in arterially implanted autogenous vein grafts, two models of canine femoral arteries were prepared. In the Group I model, the implanted autogenous vein graft was kept under a normal flow condition for 2 to 4 weeks after implantation, then was exposed to an abnormal flow (poor run-off). In case of a 3- to 4-week normal flow, intimal thickening was practically nil. Scanning electron microscopic studies showed that this 3- to 4-week period corresponded to that of re-endothelialization of the autogenous vein grafts. Immunohistochemical studies of fibrinogen distribution in the autogenous vein graft wall in the Group II model revealed that the permeation of fibrinogen was enhanced in case of an abnormal flow condition for about 2 weeks after the implantation. We interpret these observations to mean that intimal thickening was induced by an accelerated permeability in the presence of abnormal flow conditions until full re-endothelialization after the implantation.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D009131	Muscle, Smooth, Vascular	The nonstriated involuntary muscle tissue of blood vessels.	Vascular Smooth Muscle,Muscle, Vascular Smooth,Muscles, Vascular Smooth,Smooth Muscle, Vascular,Smooth Muscles, Vascular,Vascular Smooth Muscles
D004285	Dogs	The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065)	Canis familiaris,Dog
D004730	Endothelium, Vascular	Single pavement layer of cells which line the luminal surface of the entire vascular system and regulate the transport of macromolecules and blood components.	Capillary Endothelium,Vascular Endothelium,Capillary Endotheliums,Endothelium, Capillary,Endotheliums, Capillary,Endotheliums, Vascular,Vascular Endotheliums
D005260	Female		Females
D005263	Femoral Artery	The main artery of the thigh, a continuation of the external iliac artery.	Common Femoral Artery,Arteries, Common Femoral,Arteries, Femoral,Artery, Common Femoral,Artery, Femoral,Common Femoral Arteries,Femoral Arteries,Femoral Arteries, Common,Femoral Artery, Common
D005268	Femoral Vein	The vein accompanying the femoral artery in the same sheath; it is a continuation of the popliteal vein and becomes the external iliac vein.	Femoral Veins,Vein, Femoral,Veins, Femoral
D006439	Hemodynamics	The movement and the forces involved in the movement of the blood through the CARDIOVASCULAR SYSTEM.	Hemodynamic
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D014182	Transplantation, Autologous	Transplantation of an individual's own tissue from one site to another site.	Autografting,Autologous Transplantation,Autotransplantation,Autograftings,Autologous Transplantations,Autotransplantations,Transplantations, Autologous