Cerebral venous sinus thrombosis as presenting feature of ulcerative colitis. 2009

R Ennaifer, and A Moussa, and L Mouelhi, and M Salem, and S Bouzaidi, and R Debbeche, and S Trabelsi, and T Najjar
Department of Gastroenterology, Charles Nicolle Hospital, Tunis, TuniƝia. rym.ennaifer@yahoo.fr

Thrombosis is a well recognized complication of inflammatory bowel disease that occurs in 1.3 to 6.4% of patients, however, cerebral vascular involvement is unusual. We present the case of a 16-year-old female in whom cerebral venous thrombosis was the presenting symptom of an active ulcerative pancolitis. Thrombophilia screen (plasma levels of proteins C and S, antithrombin, antibeta2-glycoprotein, lupus anticoagulant and anticardiolipin antibodies, activated protein C resistance, homocystein level antinuclear antibodies) was negative. The patient was successfully treated with anticoagulant therapy, phenobarbital and sulfasalazine. Cerebral venous thrombosis is an exceptional presenting feature of ulcerative colitis. Disease activity may play a major role in the occurrence of thrombosis.

UI MeSH Term Description Entries
D003093 Colitis, Ulcerative Inflammation of the COLON that is predominantly confined to the MUCOSA. Its major symptoms include DIARRHEA, rectal BLEEDING, the passage of MUCUS, and ABDOMINAL PAIN. Colitis Gravis,Idiopathic Proctocolitis,Inflammatory Bowel Disease, Ulcerative Colitis Type,Ulcerative Colitis
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000293 Adolescent A person 13 to 18 years of age. Adolescence,Youth,Adolescents,Adolescents, Female,Adolescents, Male,Teenagers,Teens,Adolescent, Female,Adolescent, Male,Female Adolescent,Female Adolescents,Male Adolescent,Male Adolescents,Teen,Teenager,Youths
D020767 Intracranial Thrombosis Formation or presence of a blood clot (THROMBUS) in a blood vessel within the SKULL. Intracranial thrombosis can lead to thrombotic occlusions and BRAIN INFARCTION. The majority of the thrombotic occlusions are associated with ATHEROSCLEROSIS. Brain Thrombosis,Cerebral Thrombosis,Thrombosis, Brain,Thrombosis, Intracranial,Brain Thrombus,Cerebral Thrombus,Thrombus, Intracranial,Brain Thromboses,Cerebral Thromboses,Intracranial Thromboses,Intracranial Thrombus,Thromboses, Brain,Thromboses, Cerebral,Thromboses, Intracranial,Thrombosis, Cerebral,Thrombus, Brain,Thrombus, Cerebral

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