Reproductive toxicity of acrylamide-treated male rats. 2010

Hao Wang, and Pan Huang, and Tietao Lie, and Jian Li, and Reinhold J Hutz, and Kui Li, and Fangxiong Shi
Laboratory of Animal Reproduction, College of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, PR China.

Acrylamide content is elevated in fried, baked and heat-processed starchy foods. The present experiment was conducted to investigate the reproductive toxicity of oral acrylamide in male rats. Thirty weaned SD male rats of 21-day-old were randomly allotted to three groups, and acrylamide was administered to each group at doses of 0, 5 and 10 mg/kg-d for 8 consecutive weeks. The results indicated that the growth of rats treated with acrylamide was retarded (P<0.05), but relative weights of testes and epididymides compared to body weight were not significantly different (P>0.05). Our results also indicate that the epididymal sperm reserves decreased significantly (P<0.05), suggesting partial depletion of germ cells. In addition, histopathologic lesions were also present in the testes of treated rats. Furthermore, distinct expression patterns of sGC heterodimers were observed in this animal model. This may suggest different physiologic roles for sGC subunits in spermiogenesis and steroidogenesis.

UI MeSH Term Description Entries
D006965 Hyperplasia An increase in the number of cells in a tissue or organ without tumor formation. It differs from HYPERTROPHY, which is an increase in bulk without an increase in the number of cells. Hyperplasias
D007150 Immunohistochemistry Histochemical localization of immunoreactive substances using labeled antibodies as reagents. Immunocytochemistry,Immunogold Techniques,Immunogold-Silver Techniques,Immunohistocytochemistry,Immunolabeling Techniques,Immunogold Technics,Immunogold-Silver Technics,Immunolabeling Technics,Immunogold Silver Technics,Immunogold Silver Techniques,Immunogold Technic,Immunogold Technique,Immunogold-Silver Technic,Immunogold-Silver Technique,Immunolabeling Technic,Immunolabeling Technique,Technic, Immunogold,Technic, Immunogold-Silver,Technic, Immunolabeling,Technics, Immunogold,Technics, Immunogold-Silver,Technics, Immunolabeling,Technique, Immunogold,Technique, Immunogold-Silver,Technique, Immunolabeling,Techniques, Immunogold,Techniques, Immunogold-Silver,Techniques, Immunolabeling
D007985 Leydig Cells Steroid-producing cells in the interstitial tissue of the TESTIS. They are under the regulation of PITUITARY HORMONES; LUTEINIZING HORMONE; or interstitial cell-stimulating hormone. TESTOSTERONE is the major androgen (ANDROGENS) produced. Interstitial Cells, Testicular,Leydig Cell,Testicular Interstitial Cell,Testicular Interstitial Cells,Cell, Leydig,Cell, Testicular Interstitial,Cells, Leydig,Cells, Testicular Interstitial,Interstitial Cell, Testicular
D008297 Male Males
D009929 Organ Size The measurement of an organ in volume, mass, or heaviness. Organ Volume,Organ Weight,Size, Organ,Weight, Organ
D001835 Body Weight The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms. Body Weights,Weight, Body,Weights, Body
D004822 Epididymis The convoluted cordlike structure attached to the posterior of the TESTIS. Epididymis consists of the head (caput), the body (corpus), and the tail (cauda). A network of ducts leaving the testis joins into a common epididymal tubule proper which provides the transport, storage, and maturation of SPERMATOZOA.
D006128 Growth Gradual increase in the number, the size, and the complexity of cells of an individual. Growth generally results in increase in ORGAN WEIGHT; BODY WEIGHT; and BODY HEIGHT.
D006162 Guanylate Cyclase An enzyme that catalyzes the conversion of GTP to 3',5'-cyclic GMP and pyrophosphate. It also acts on ITP and dGTP. (From Enzyme Nomenclature, 1992) EC 4.6.1.2. Guanyl Cyclase,Deoxyguanylate Cyclase,Guanylyl Cyclase,Inosinate Cyclase,Cyclase, Deoxyguanylate,Cyclase, Guanyl,Cyclase, Guanylate,Cyclase, Guanylyl,Cyclase, Inosinate
D000071756 Soluble Guanylyl Cyclase A mammalian enzyme composed of a heterodimer of alpha and beta subunits. Each subunit consists of four domains; N-terminal HNOX domain, PAS-like domain, a coiled-coil domain, and a C-terminal catalytic domain. All four domains are homologous proteins with a similar conformation of functional domains. Soluble guanylate cyclase catalyzes the formation of cyclic GMP from GTP, and is a key enzyme of the nitric oxide signaling pathway involved in the regulation of a variety of biological and physiological processes in mammals. Nitric Oxide Receptor,Nitric Oxide Receptors,Nitric Oxide-Sensitive Guanylyl Cyclase,Receptor, Nitric Oxide,Soluble Guanylate Cyclase,Soluble Guanylyl Cyclase, alpha Subunit,Soluble Guanylyl Cyclase, beta Subunit,Cyclase, Soluble Guanylate,Cyclase, Soluble Guanylyl,Guanylate Cyclase, Soluble,Guanylyl Cyclase, Soluble,Nitric Oxide Sensitive Guanylyl Cyclase,Oxide Receptor, Nitric,Oxide Receptors, Nitric

Related Publications

Hao Wang, and Pan Huang, and Tietao Lie, and Jian Li, and Reinhold J Hutz, and Kui Li, and Fangxiong Shi
January 1986, Journal of toxicology and environmental health,
Hao Wang, and Pan Huang, and Tietao Lie, and Jian Li, and Reinhold J Hutz, and Kui Li, and Fangxiong Shi
July 2014, Reproductive toxicology (Elmsford, N.Y.),
Hao Wang, and Pan Huang, and Tietao Lie, and Jian Li, and Reinhold J Hutz, and Kui Li, and Fangxiong Shi
July 2022, Animals : an open access journal from MDPI,
Hao Wang, and Pan Huang, and Tietao Lie, and Jian Li, and Reinhold J Hutz, and Kui Li, and Fangxiong Shi
January 2000, Reproductive toxicology (Elmsford, N.Y.),
Hao Wang, and Pan Huang, and Tietao Lie, and Jian Li, and Reinhold J Hutz, and Kui Li, and Fangxiong Shi
April 1993, Indian journal of experimental biology,
Hao Wang, and Pan Huang, and Tietao Lie, and Jian Li, and Reinhold J Hutz, and Kui Li, and Fangxiong Shi
June 2007, Zhonghua nan ke xue = National journal of andrology,
Hao Wang, and Pan Huang, and Tietao Lie, and Jian Li, and Reinhold J Hutz, and Kui Li, and Fangxiong Shi
February 2021, Scientific reports,
Hao Wang, and Pan Huang, and Tietao Lie, and Jian Li, and Reinhold J Hutz, and Kui Li, and Fangxiong Shi
April 2017, Birth defects research,
Hao Wang, and Pan Huang, and Tietao Lie, and Jian Li, and Reinhold J Hutz, and Kui Li, and Fangxiong Shi
June 2004, Reproductive medicine and biology,
Hao Wang, and Pan Huang, and Tietao Lie, and Jian Li, and Reinhold J Hutz, and Kui Li, and Fangxiong Shi
February 2003, Bulletin of environmental contamination and toxicology,
Copied contents to your clipboard!