BIOMAT Database Logo BIOMAT Database Logo

Human immunodeficiency virus infection of human-PBL-SCID mice. 1991

D E Mosier, and R J Gulizia, and S M Baird, and D B Wilson, and D H Spector, and S A Spector
Division of Immunology, Medical Biology Institute, La Jolla, CA 92037.

Severe combined immunodeficient (SCID) mice reconstituted with human peripheral blood leukocytes (hu-PBL-SCID mice) have inducible human immune function and may be useful as a small animal model for acquired immunodeficiency syndrome (AIDS) research. Hu-PBL-SCID mice infected with human immunodeficiency virus-1 (HIV-1) contained virus that was recoverable by culture from the peritoneal cavity, spleen, peripheral blood, and lymph nodes for up to 16 weeks after infection; viral sequences were also detected by in situ hybridization and by amplification with the polymerase chain reaction (PCR). Mice could be infected with multiple strains of HIV-1, including LAV-1/Bru, IIIB, MN, SF2, and SF13. HIV-1 infection affected the concentration of human immunoglobulin and the number of CD4+ T cells in the mice. These results support the use of the hu-PBL-SCID mouse for studies of the pathogenesis and treatment of AIDS.

UI MeSH Term Description Entries
D007153 Immunologic Deficiency Syndromes Syndromes in which there is a deficiency or defect in the mechanisms of immunity, either cellular or humoral. Antibody Deficiency Syndrome,Deficiency Syndrome, Immunologic,Deficiency Syndromes, Antibody,Deficiency Syndromes, Immunologic,Immunologic Deficiency Syndrome,Immunological Deficiency Syndromes,Antibody Deficiency Syndromes,Deficiency Syndrome, Antibody,Deficiency Syndrome, Immunological,Deficiency Syndromes, Immunological,Immunological Deficiency Syndrome,Syndrome, Antibody Deficiency,Syndrome, Immunologic Deficiency,Syndrome, Immunological Deficiency,Syndromes, Antibody Deficiency,Syndromes, Immunologic Deficiency,Syndromes, Immunological Deficiency
D008817 Mice, Mutant Strains Mice bearing mutant genes which are phenotypically expressed in the animals. Mouse, Mutant Strain,Mutant Mouse Strain,Mutant Strain of Mouse,Mutant Strains of Mice,Mice Mutant Strain,Mice Mutant Strains,Mouse Mutant Strain,Mouse Mutant Strains,Mouse Strain, Mutant,Mouse Strains, Mutant,Mutant Mouse Strains,Mutant Strain Mouse,Mutant Strains Mice,Strain Mouse, Mutant,Strain, Mutant Mouse,Strains Mice, Mutant,Strains, Mutant Mouse
D001803 Blood Transfusion The introduction of whole blood or blood component directly into the blood stream. (Dorland, 27th ed) Blood Transfusions,Transfusion, Blood,Transfusions, Blood
D002678 Chimera An individual that contains cell populations derived from different zygotes. Hybrids,Chimeras,Hybrid
D004195 Disease Models, Animal Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases. Animal Disease Model,Animal Disease Models,Disease Model, Animal
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D013154 Spleen An encapsulated lymphatic organ through which venous blood filters.
D015497 HIV-1 The type species of LENTIVIRUS and the etiologic agent of AIDS. It is characterized by its cytopathic effect and affinity for the T4-lymphocyte. Human immunodeficiency virus 1,HIV-I,Human Immunodeficiency Virus Type 1,Immunodeficiency Virus Type 1, Human
D015658 HIV Infections Includes the spectrum of human immunodeficiency virus infections that range from asymptomatic seropositivity, thru AIDS-related complex (ARC), to acquired immunodeficiency syndrome (AIDS). HTLV-III Infections,HTLV-III-LAV Infections,T-Lymphotropic Virus Type III Infections, Human,HIV Coinfection,Coinfection, HIV,Coinfections, HIV,HIV Coinfections,HIV Infection,HTLV III Infections,HTLV III LAV Infections,HTLV-III Infection,HTLV-III-LAV Infection,Infection, HIV,Infection, HTLV-III,Infection, HTLV-III-LAV,Infections, HIV,Infections, HTLV-III,Infections, HTLV-III-LAV,T Lymphotropic Virus Type III Infections, Human

Related Publications

D E Mosier, and R J Gulizia, and S M Baird, and D B Wilson, and D H Spector, and S A Spector
Transfer of human CD4(+) T lymphocytes producing beta interferon in Hu-PBL-SCID mice controls human immunodeficiency virus infection.
December 1999, Journal of virology,
D E Mosier, and R J Gulizia, and S M Baird, and D B Wilson, and D H Spector, and S A Spector
Human immunodeficiency virus infection of xenografted SCID-beige mice.
October 1995, Journal of medical virology,
D E Mosier, and R J Gulizia, and S M Baird, and D B Wilson, and D H Spector, and S A Spector
Potent activity of 2'-beta-fluoro-2',3'-dideoxyadenosine against human immunodeficiency virus type 1 infection in hu-PBL-SCID mice.
October 1996, Antimicrobial agents and chemotherapy,
D E Mosier, and R J Gulizia, and S M Baird, and D B Wilson, and D H Spector, and S A Spector
Human immunodeficiency virus encephalitis in SCID mice.
September 1996, The American journal of pathology,
D E Mosier, and R J Gulizia, and S M Baird, and D B Wilson, and D H Spector, and S A Spector
Quantitative assessment of human immunodeficiency virus type 1 replication in human xenografts of acutely infected Hu-PBL-SCID mice.
March 1994, AIDS research and human retroviruses,
D E Mosier, and R J Gulizia, and S M Baird, and D B Wilson, and D H Spector, and S A Spector
CD4-immunoglobulin G2 protects Hu-PBL-SCID mice against challenge by primary human immunodeficiency virus type 1 isolates.
April 1998, Journal of virology,
D E Mosier, and R J Gulizia, and S M Baird, and D B Wilson, and D H Spector, and S A Spector
[Model of viral infection in SCID mice: SCID-hu mouse and hu-PBL-SCID mouse].
June 1999, Uirusu,
D E Mosier, and R J Gulizia, and S M Baird, and D B Wilson, and D H Spector, and S A Spector
Dose-dependent systemic human immunodeficiency virus infection of SCID-hu mice after intraperitoneal virus injection.
January 1995, Research in virology,
D E Mosier, and R J Gulizia, and S M Baird, and D B Wilson, and D H Spector, and S A Spector
The human immune system in hu-PBL-SCID mice.
November 1995, Immunology today,
D E Mosier, and R J Gulizia, and S M Baird, and D B Wilson, and D H Spector, and S A Spector
A model of human immunodeficiency virus encephalitis in scid mice.
September 1993, Proceedings of the National Academy of Sciences of the United States of America,
Copied contents to your clipboard!