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In the present study 8 anephric and 4 non-nephrectomized patients were stimulated with angiotensin II (A-II). In 5 of the anephric patients, an increased plasma aldosterone concentration (PAC) in response to ACTH stimulation had previously been demonstrated. After A-II stimulation, all 8 anephric patients responded with a significant rise in PAC although the increase was less pronounced than in 4 non-nephrectomized patients. In both groups of patients the increase in PAC was correlated to the increase in diastolic and systolic BP and to the A-II dose. Furthermore, in the non-nephrectomized patients, the plasma renin activity showed a significant decline, which was inversely correlated to the increase in PAC. When all 12 patients, regardless of the difference in remaining renin-angiotensin system, were considered as one population, the variable basal levels of PAC correlated significantly to the increase in PAC during A-II and ACTH stimulation. It is concluded that the adrenals of anephric man respond to A-II with an increase in PAC and that the reason for a lower response appears to be the lack of the renin-angiotensin system.
K Olgaard, and
S Madsen, and
M Hammer
February 1980,
Danish medical bulletin,
K Olgaard, and
S Madsen, and
M Hammer
April 1993,
The Tohoku journal of experimental medicine,
K Olgaard, and
S Madsen, and
M Hammer
August 1976,
Circulation research,
K Olgaard, and
S Madsen, and
M Hammer
October 1971,
Israel journal of medical sciences,
K Olgaard, and
S Madsen, and
M Hammer
July 1993,
Kidney international,
K Olgaard, and
S Madsen, and
M Hammer
January 1981,
Clinical and experimental dialysis and apheresis,
K Olgaard, and
S Madsen, and
M Hammer
December 1975,
The American journal of physiology,
K Olgaard, and
S Madsen, and
M Hammer
April 1981,
Clinical nephrology,
K Olgaard, and
S Madsen, and
M Hammer
January 1986,
ASAIO transactions,
K Olgaard, and
S Madsen, and
M Hammer
November 2011,
Endocrinology,
