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Peptide thioester synthesis through N-->S acyl-transfer: application to the synthesis of a beta-defensin. 2009

Jaskiranjit Kang, and Natalie L Reynolds, and Christine Tyrrell, and Julia R Dorin, and Derek Macmillan
Department of Chemistry, University College London, 20 Gordon Street, London, UK WC1H 0AJ.

Peptide thioesters readily prepared through N-->S acyl transfer of a specific C-terminal motif provide access to biologically active mini-proteins using native chemical ligation.

UI MeSH Term Description Entries
D004952 Esters Compounds derived from organic or inorganic acids in which at least one hydroxyl group is replaced by an –O-alkyl or another organic group. They can be represented by the structure formula RCOOR’ and are usually formed by the reaction between an acid and an alcohol with elimination of water. Ester
D013438 Sulfhydryl Compounds Compounds containing the -SH radical. Mercaptan,Mercapto Compounds,Sulfhydryl Compound,Thiol,Thiols,Mercaptans,Compound, Sulfhydryl,Compounds, Mercapto,Compounds, Sulfhydryl
D013997 Time Factors Elements of limited time intervals, contributing to particular results or situations. Time Series,Factor, Time,Time Factor
D015394 Molecular Structure The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds. Structure, Molecular,Molecular Structures,Structures, Molecular
D023083 beta-Defensins DEFENSINS found mainly in epithelial cells. beta-Defensin,beta Defensin,beta Defensins

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