-transparent.png){kind=logo}
Peripheral neuropathy is a rare complication of dapsone therapy. This neuropathy appears primarily to be of the motor type, and recovery occurs on discontinuation of the drug therapy. The patient in this report developed a marked motor deficit as well as a selective marked loss of vibration sense shortly after the initiation of a relatively low dose of dapsone. Recovery was rapid on cessation of the therapy. This patient was found to be a slow acetylator of isoniazid, and therefore is probably a slow acetylator of dapsone. The possible mechanisms of the neurotoxicity of dapsone and the role of altered metabolism are discussed.
Related Publications
W C Koller, and
L K Gehlmann, and
F D Malkinson, and
F A Davis
August 1972,
Archives of neurology,
W C Koller, and
L K Gehlmann, and
F D Malkinson, and
F A Davis
May 1972,
The British journal of dermatology,
W C Koller, and
L K Gehlmann, and
F D Malkinson, and
F A Davis
June 1986,
International journal of dermatology,
W C Koller, and
L K Gehlmann, and
F D Malkinson, and
F A Davis
December 1976,
Archives of dermatology,
W C Koller, and
L K Gehlmann, and
F D Malkinson, and
F A Davis
April 2003,
Annales de dermatologie et de venereologie,
W C Koller, and
L K Gehlmann, and
F D Malkinson, and
F A Davis
July 1989,
Muscle & nerve,
W C Koller, and
L K Gehlmann, and
F D Malkinson, and
F A Davis
June 1974,
Proceedings of the Royal Society of Medicine,
W C Koller, and
L K Gehlmann, and
F D Malkinson, and
F A Davis
March 1995,
Clinical and experimental dermatology,
W C Koller, and
L K Gehlmann, and
F D Malkinson, and
F A Davis
March 1984,
Archives of dermatology,
W C Koller, and
L K Gehlmann, and
F D Malkinson, and
F A Davis
June 1977,
Archives of dermatology,
