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To investigate alterations in the basement membrane (BM) in squamous cell carcinoma (SCC), we investigated 20 tumors. Four had the cytologic characteristics of Bowen's disease (SCC-BD) and 16 did not have them (SCC-NB). Tumors were studied immunohistochemically by double immunofluorescent staining by using mouse monoclonal antibodies to the core protein of heparan sulfate proteoglycan (HSPG) and chondroitin 6-sulfate glycosaminoglycan (Ch6S) as well as rabbit antiserum to laminin (LN) and type IV collagen (C-4). In well-differentiated and highly keratinized SCC-NB, LN, C-4, and HSPG could be detected in the tumor nest BM and showed no loss of continuity, but they were largely lost in poorly differentiated and poorly keratinized SCC-NB. This suggests that poorly differentiated SCC-NB cause greater enzymatic degradation of BM components than well-differentiated SCC-NB. Ch6S was detected in parts of the BM of SCC-BD, but it was absent in all SCC-NB examined. It appears that SCC-NB have lost the ability to synthesize Ch6S, and that SCC-BD degrade Ch6S although they continue to produce it. Thus, it appears that in SCC the BM is qualitatively different from that of normal epidermis, and that SCC-BD can be distinguished from SCC-NB by the Ch6S content of the BM.
K Oguro, and
T Kazama, and
M Isemura, and
T Nakamura, and
S Akai, and
Y Sato
February 1991,
Nihon Hifuka Gakkai zasshi. The Japanese journal of dermatology,
K Oguro, and
T Kazama, and
M Isemura, and
T Nakamura, and
S Akai, and
Y Sato
January 1986,
Dermatologische Monatschrift,
K Oguro, and
T Kazama, and
M Isemura, and
T Nakamura, and
S Akai, and
Y Sato
December 2000,
Zhonghua er bi yan hou ke za zhi,
K Oguro, and
T Kazama, and
M Isemura, and
T Nakamura, and
S Akai, and
Y Sato
July 1997,
Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology,
K Oguro, and
T Kazama, and
M Isemura, and
T Nakamura, and
S Akai, and
Y Sato
January 1994,
Head & neck,
K Oguro, and
T Kazama, and
M Isemura, and
T Nakamura, and
S Akai, and
Y Sato
May 2013,
Journal of oral and maxillofacial pathology : JOMFP,
K Oguro, and
T Kazama, and
M Isemura, and
T Nakamura, and
S Akai, and
Y Sato
December 1994,
Laryngo- rhino- otologie,
K Oguro, and
T Kazama, and
M Isemura, and
T Nakamura, and
S Akai, and
Y Sato
September 1983,
Laboratory investigation; a journal of technical methods and pathology,
K Oguro, and
T Kazama, and
M Isemura, and
T Nakamura, and
S Akai, and
Y Sato
January 1990,
Head & neck,
K Oguro, and
T Kazama, and
M Isemura, and
T Nakamura, and
S Akai, and
Y Sato
July 1991,
The British journal of dermatology,
