Cis-regulatory mechanisms of gene expression in an olfactory neuron type in Caenorhabditis elegans. 2009

Eva B Nokes, and Alexander M Van Der Linden, and Caron Winslow, and Saikat Mukhopadhyay, and Kristin Ma, and Piali Sengupta
Department of Biology and National Center for Behavioral Genomics, Brandeis University, Waltham, Massachusetts 02454, USA.

The generation of cellular diversity is dependent on the precise spatiotemporal regulation of gene expression by both cis- and trans-acting mechanisms. The developmental principles regulating expression of specific gene subsets in individual cell types are not fully understood. Here we define the cis-regulatory mechanisms driving expression of cell-selective and broadly expressed genes in vivo in the AWB olfactory neuron subtype in C. elegans. We identify an element that is necessary to drive expression of neuron-selective chemoreceptor genes in the AWB neurons, and show that this element functions in a context-dependent manner. We find that the expression of broadly expressed sensory neuronal genes in the AWB neurons is regulated by diverse cis- and trans-regulatory mechanisms that act partly in parallel to the pathways governing expression of AWB-selective genes. We further demonstrate that cis-acting mechanisms driving gene expression in the AWB neurons appear to have diverged in related nematode species. Our results provide insights into the cis-regulatory logic driving cell-specific gene expression, and suggest that variations in this logic contribute to the generation of functional diversity.

UI MeSH Term Description Entries
D008954 Models, Biological Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment. Biological Model,Biological Models,Model, Biological,Models, Biologic,Biologic Model,Biologic Models,Model, Biologic
D008969 Molecular Sequence Data Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories. Sequence Data, Molecular,Molecular Sequencing Data,Data, Molecular Sequence,Data, Molecular Sequencing,Sequencing Data, Molecular
D009832 Olfactory Nerve The 1st cranial nerve. The olfactory nerve conveys the sense of smell. It is formed by the axons of OLFACTORY RECEPTOR NEURONS which project from the olfactory epithelium (in the nasal epithelium) to the OLFACTORY BULB. Cranial Nerve I,First Cranial Nerve,Nervus Olfactorius,Fila Olfactoria,Olfactory Fila,Cranial Nerve Is,Cranial Nerve, First,Cranial Nerves, First,First Cranial Nerves,Nerve I, Cranial,Nerve Is, Cranial,Nerve, First Cranial,Nerve, Olfactory,Nerves, Olfactory,Olfactory Nerves
D012045 Regulatory Sequences, Nucleic Acid Nucleic acid sequences involved in regulating the expression of genes. Nucleic Acid Regulatory Sequences,Regulatory Regions, Nucleic Acid (Genetics),Region, Regulatory,Regions, Regulatory,Regulator Regions, Nucleic Acid,Regulatory Region,Regulatory Regions
D004625 Embryo, Nonmammalian The developmental entity of a fertilized egg (ZYGOTE) in animal species other than MAMMALS. For chickens, use CHICK EMBRYO. Embryonic Structures, Nonmammalian,Embryo, Non-Mammalian,Embryonic Structures, Non-Mammalian,Nonmammalian Embryo,Nonmammalian Embryo Structures,Nonmammalian Embryonic Structures,Embryo Structure, Nonmammalian,Embryo Structures, Nonmammalian,Embryo, Non Mammalian,Embryonic Structure, Non-Mammalian,Embryonic Structure, Nonmammalian,Embryonic Structures, Non Mammalian,Embryos, Non-Mammalian,Embryos, Nonmammalian,Non-Mammalian Embryo,Non-Mammalian Embryonic Structure,Non-Mammalian Embryonic Structures,Non-Mammalian Embryos,Nonmammalian Embryo Structure,Nonmammalian Embryonic Structure,Nonmammalian Embryos,Structure, Non-Mammalian Embryonic,Structure, Nonmammalian Embryo,Structure, Nonmammalian Embryonic,Structures, Non-Mammalian Embryonic,Structures, Nonmammalian Embryo,Structures, Nonmammalian Embryonic
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D001482 Base Composition The relative amounts of the PURINES and PYRIMIDINES in a nucleic acid. Base Ratio,G+C Composition,Guanine + Cytosine Composition,G+C Content,GC Composition,GC Content,Guanine + Cytosine Content,Base Compositions,Base Ratios,Composition, Base,Composition, G+C,Composition, GC,Compositions, Base,Compositions, G+C,Compositions, GC,Content, G+C,Content, GC,Contents, G+C,Contents, GC,G+C Compositions,G+C Contents,GC Compositions,GC Contents,Ratio, Base,Ratios, Base
D001483 Base Sequence The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence. DNA Sequence,Nucleotide Sequence,RNA Sequence,DNA Sequences,Base Sequences,Nucleotide Sequences,RNA Sequences,Sequence, Base,Sequence, DNA,Sequence, Nucleotide,Sequence, RNA,Sequences, Base,Sequences, DNA,Sequences, Nucleotide,Sequences, RNA
D012689 Sequence Homology, Nucleic Acid The sequential correspondence of nucleotides in one nucleic acid molecule with those of another nucleic acid molecule. Sequence homology is an indication of the genetic relatedness of different organisms and gene function. Base Sequence Homology,Homologous Sequences, Nucleic Acid,Homologs, Nucleic Acid Sequence,Homology, Base Sequence,Homology, Nucleic Acid Sequence,Nucleic Acid Sequence Homologs,Nucleic Acid Sequence Homology,Sequence Homology, Base,Base Sequence Homologies,Homologies, Base Sequence,Sequence Homologies, Base
D013045 Species Specificity The restriction of a characteristic behavior, anatomical structure or physical system, such as immune response; metabolic response, or gene or gene variant to the members of one species. It refers to that property which differentiates one species from another but it is also used for phylogenetic levels higher or lower than the species. Species Specificities,Specificities, Species,Specificity, Species

Related Publications

Eva B Nokes, and Alexander M Van Der Linden, and Caron Winslow, and Saikat Mukhopadhyay, and Kristin Ma, and Piali Sengupta
May 2015, Genetics,
Eva B Nokes, and Alexander M Van Der Linden, and Caron Winslow, and Saikat Mukhopadhyay, and Kristin Ma, and Piali Sengupta
March 2015, PLoS genetics,
Eva B Nokes, and Alexander M Van Der Linden, and Caron Winslow, and Saikat Mukhopadhyay, and Kristin Ma, and Piali Sengupta
December 2003, Genetics,
Eva B Nokes, and Alexander M Van Der Linden, and Caron Winslow, and Saikat Mukhopadhyay, and Kristin Ma, and Piali Sengupta
January 2009, Development (Cambridge, England),
Eva B Nokes, and Alexander M Van Der Linden, and Caron Winslow, and Saikat Mukhopadhyay, and Kristin Ma, and Piali Sengupta
March 2010, BMC molecular biology,
Eva B Nokes, and Alexander M Van Der Linden, and Caron Winslow, and Saikat Mukhopadhyay, and Kristin Ma, and Piali Sengupta
October 2003, Journal of molecular biology,
Eva B Nokes, and Alexander M Van Der Linden, and Caron Winslow, and Saikat Mukhopadhyay, and Kristin Ma, and Piali Sengupta
April 1997, Molecular and cellular biology,
Eva B Nokes, and Alexander M Van Der Linden, and Caron Winslow, and Saikat Mukhopadhyay, and Kristin Ma, and Piali Sengupta
August 2008, Proceedings of the National Academy of Sciences of the United States of America,
Eva B Nokes, and Alexander M Van Der Linden, and Caron Winslow, and Saikat Mukhopadhyay, and Kristin Ma, and Piali Sengupta
May 2003, Developmental biology,
Eva B Nokes, and Alexander M Van Der Linden, and Caron Winslow, and Saikat Mukhopadhyay, and Kristin Ma, and Piali Sengupta
April 2009, Genetics,
Copied contents to your clipboard!