Biomaterial Database

Eye movement abnormalities in somatic tinnitus: fixation, smooth pursuit and optokinetic nystagmus. 2010

Z Kapoula, and Q Yang, and M Vernet, and P Bonfils, and A Londero

Laboratoire IRIS, CNRS, FRE 3154, Service d'Ophtalmologie-ORL-Stomatologie, Hôpital Européen Georges Pompidou, 20 rue Leblanc, Paris, France. zoi.kapoula@egp.aphp.fr

OBJECTIVE Smooth pursuit (SP), optokinetic nystagmus (OKN) and fixation were investigated in five subjects with somatic tinnitus modulated by eye movements, jaw or neck. METHODS Eye movements were recorded with the EyeLink II video system. RESULTS (1) Fixation was characterized by high frequency and amplitude of saccade intrusions; (2) SP had low gain particularly in the vertical direction, and it was characterized by high frequency of catch-up saccades with high amplitude, including predictive saccades; (3) OKN also had low gain particularly in the vertical direction. Each subject showed abnormality for more than one type of eye movement, and for specific directions. CONCLUSIONS The results suggest mild dysfunction of cortical-subcortical and cerebellar structures involved in the control of these eye movements. Particularly deficits for vertical pursuit eye movements and fixation instability in line with cerebellar signs. Further studies of more patients with or without modulated tinnitus are in progress.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D008875	Middle Aged	An adult aged 45 - 64 years.	Middle Age
D011698	Pursuit, Smooth	Eye movements that are slow, continuous, and conjugate and occur when a fixed object is moved slowly.	Pursuits, Smooth,Smooth Pursuit,Smooth Pursuits
D005133	Eye Movements	Voluntary or reflex-controlled movements of the eye.	Eye Movement,Movement, Eye,Movements, Eye
D005260	Female		Females
D005403	Fixation, Ocular	Positioning and accommodation of eyes that allows the image to be brought into place on the FOVEA CENTRALIS of each eye.	Focusing, Ocular,Ocular Fixation,Eye Gaze,Eye Gazes,Gaze, Eye,Gazes, Eye,Ocular Focusing
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D013001	Somatoform Disorders	Disorders having the presence of physical symptoms that suggest a general medical condition but that are not fully explained by another medical condition, by the direct effects of a substance, or by another mental disorder. The MEDICALLY UNEXPLAINED SYMPTOMS must cause clinically significant distress or impairment in social, occupational, or other areas of functioning. In contrast to FACTITIOUS DISORDERS and MALINGERING, the physical symptoms are not under voluntary control. (APA, DSM-V)	Briquet Syndrome,Pain Disorder,Somatization Disorder,Medically Unexplained Syndrome,Medically Unexplained Syndromes,Disorder, Somatoform,Somatization Disorders,Somatoform Disorder,Syndrome, Briquet,Syndrome, Medically Unexplained,Unexplained Syndrome, Medically
D014012	Tinnitus	A nonspecific symptom of hearing disorder characterized by the sensation of buzzing, ringing, clicking, pulsations, and other noises in the ear. Objective tinnitus refers to noises generated from within the ear or adjacent structures that can be heard by other individuals. The term subjective tinnitus is used when the sound is audible only to the affected individual. Tinnitus may occur as a manifestation of COCHLEAR DISEASES; VESTIBULOCOCHLEAR NERVE DISEASES; INTRACRANIAL HYPERTENSION; CRANIOCEREBRAL TRAUMA; and other conditions.	Pulsatile Tinnitus,Ringing-Buzzing-Tinnitus,Spontaneous Oto-Acoustic Emission Tinnitus,Tensor Palatini Induced Tinnitus,Tensor Tympani Induced Tinnitus,Tinnitus of Vascular Origin,Tinnitus, Clicking,Tinnitus, Leudet,Tinnitus, Leudet's,Tinnitus, Noise Induced,Tinnitus, Objective,Tinnitus, Spontaneous Oto-Acoustic Emission,Tinnitus, Subjective,Tinnitus, Tensor Palatini Induced,Tinnitus, Tensor Tympani Induced,Vascular Origin Tinnitus,Clicking Tinnitus,Induced Tinnitus, Noise,Leudet Tinnitus,Leudet's Tinnitus,Noise Induced Tinnitus,Objective Tinnitus,Ringing Buzzing Tinnitus,Spontaneous Oto Acoustic Emission Tinnitus,Subjective Tinnitus,Tinnitus, Leudets,Tinnitus, Pulsatile,Tinnitus, Spontaneous Oto Acoustic Emission,Tinnitus, Vascular Origin
D017120	Nystagmus, Optokinetic	Normal nystagmus produced by looking at objects moving across the field of vision.	Optokinetic Nystagmus