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Necrotizing lymphadenitis: Kikuchi--Fujimoto disease alias lupus lymphadenitis? 2010

Jp Cramer, and S Schmiedel, and N G Alegre, and H Schäfer, and G D Burchard, and H Merz
Section for Tropical Medicine, I, Department of Internal Medicine, University Medical Centre Hamburg-Eppendorf, Bernhard-Nocht-Strasse 74, 20359 Hamburg, Germany.

Differentiation between lymphadenopathy in potentially life-threatening systemic lupus erythematosus (SLE) and self-limiting necrotizing lymphadenitis, also called Kikuchi- Fujimoto disease (KFD), is difficult. In the past, co-occurrence of SLE and KFD has been described repeatedly in case reports. Here, we report a case of necrotizing lymphadenitis, describe the clinical and histopathologic features in detail and discuss the current literature. KFD may in fact be a histopathologic characteristic of SLE supporting the hypothesis that KFD is a rare manifestation of SLE. To clarify whether KFD is the same entity as lupus lymphadenitis, more cases with SLE and lymphadenopathy should be examined in detail.

UI MeSH Term Description Entries
D008180 Lupus Erythematosus, Systemic A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys, and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow. Libman-Sacks Disease,Lupus Erythematosus Disseminatus,Systemic Lupus Erythematosus,Disease, Libman-Sacks,Libman Sacks Disease
D008199 Lymphadenitis Inflammation of the lymph nodes. Adenitis,Adenitides,Lymphadenitides
D008297 Male Males
D009336 Necrosis The death of cells in an organ or tissue due to disease, injury or failure of the blood supply.
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000328 Adult A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available. Adults
D020042 Histiocytic Necrotizing Lymphadenitis Development of lesions in the lymph node characterized by infiltration of the cortex or paracortex by large collections of proliferating histiocytes and complete or, more often, incomplete necrosis of lymphoid tissue. Kikuchi Disease,Lymphadenitis, Histiocytic Necrotizing,Histiocytic Necrotising Lymphadenitis,Kikuchi Necrotizing Lymphadenitis,Kikuchi's Disease,Kikuchi-Fujimoto Disease,Kikuchi-Fujimoto's Disease,Nosocomial Kikuchi's Disease,Disease, Kikuchi,Disease, Kikuchi's,Disease, Kikuchi-Fujimoto,Disease, Kikuchi-Fujimoto's,Histiocytic Necrotising Lymphadenitides,Kikuchi Fujimoto Disease,Kikuchi Fujimoto's Disease,Kikuchi's Disease, Nosocomial,Kikuchi-Fujimotos Disease,Kikuchis Disease,Lymphadenitides, Histiocytic Necrotising,Lymphadenitis, Histiocytic Necrotising,Lymphadenitis, Kikuchi Necrotizing,Necrotising Lymphadenitides, Histiocytic,Necrotising Lymphadenitis, Histiocytic,Necrotizing Lymphadenitis, Histiocytic,Necrotizing Lymphadenitis, Kikuchi,Nosocomial Kikuchi Disease,Nosocomial Kikuchis Disease

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