BIOMAT Database Logo BIOMAT Database Logo

Different routes of bacterial infection induce long-lived TH1 memory cells and short-lived TH17 cells. 2010

Marion Pepper, and Jonathan L Linehan, and Antonio J Pagán, and Traci Zell, and Thamotharampillai Dileepan, and P Patrick Cleary, and Marc K Jenkins
Department of Microbiology, Center for Immunology, University of Minnesota Medical School, Minneapolis, Minnesota, USA.

We used a sensitive method based on tetramers of peptide and major histocompatibility complex II (pMHCII) to determine whether CD4(+) memory T cells resemble the T helper type 1 (T(H)1) and interleukin 17 (IL-17)-producing T helper (T(H)17) subsets described in vitro. Intravenous or intranasal infection with Listeria monocytogenes induced pMHCII-specific CD4(+) naive T cells to proliferate and produce effector cells, about 10% of which resembled T(H)1 or T(H)17 cells, respectively. T(H)1 cells were also present among the memory cells that survived 3 months after infection, whereas T(H)17 cells disappeared. The short lifespan of T(H)17 cells was associated with small amounts of the antiapoptotic protein Bcl-2, the IL-15 receptor and the receptor CD27, and little homeostatic proliferation. These results suggest that T(H)1 cells induced by intravenous infection are more efficient at entering the memory pool than are T(H)17 cells induced by intranasal infection.

UI MeSH Term Description Entries
D007156 Immunologic Memory The altered state of immunologic responsiveness resulting from initial contact with antigen, which enables the individual to produce antibodies more rapidly and in greater quantity in response to secondary antigenic stimulus. Immune Memory,Immunological Memory,Memory, Immunologic,Immune Memories,Immunologic Memories,Immunological Memories,Memory, Immune,Memory, Immunological
D007371 Interferon-gamma The major interferon produced by mitogenically or antigenically stimulated LYMPHOCYTES. It is structurally different from TYPE I INTERFERON and its major activity is immunoregulation. It has been implicated in the expression of CLASS II HISTOCOMPATIBILITY ANTIGENS in cells that do not normally produce them, leading to AUTOIMMUNE DISEASES. Interferon Type II,Interferon, Immune,gamma-Interferon,Interferon, gamma,Type II Interferon,Immune Interferon,Interferon, Type II
D008088 Listeriosis Infections with bacteria of the genus LISTERIA. Listeria Infections,Infections, Listeria,Infection, Listeria,Listeria Infection,Listerioses
D008089 Listeria monocytogenes A species of gram-positive, rod-shaped bacteria widely distributed in nature. It has been isolated from sewage, soil, silage, and from feces of healthy animals and man. Infection with this bacterium leads to encephalitis, meningitis, endocarditis, and abortion.
D008810 Mice, Inbred C57BL One of the first INBRED MOUSE STRAINS to be sequenced. This strain is commonly used as genetic background for transgenic mouse models. Refractory to many tumors, this strain is also preferred model for studying role of genetic variations in development of diseases. Mice, C57BL,Mouse, C57BL,Mouse, Inbred C57BL,C57BL Mice,C57BL Mice, Inbred,C57BL Mouse,C57BL Mouse, Inbred,Inbred C57BL Mice,Inbred C57BL Mouse
D008815 Mice, Inbred Strains Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations, or by parent x offspring matings carried out with certain restrictions. All animals within an inbred strain trace back to a common ancestor in the twentieth generation. Inbred Mouse Strains,Inbred Strain of Mice,Inbred Strain of Mouse,Inbred Strains of Mice,Mouse, Inbred Strain,Inbred Mouse Strain,Mouse Inbred Strain,Mouse Inbred Strains,Mouse Strain, Inbred,Mouse Strains, Inbred,Strain, Inbred Mouse,Strains, Inbred Mouse
D002454 Cell Differentiation Progressive restriction of the developmental potential and increasing specialization of function that leads to the formation of specialized cells, tissues, and organs. Differentiation, Cell,Cell Differentiations,Differentiations, Cell
D002460 Cell Line Established cell cultures that have the potential to propagate indefinitely. Cell Lines,Line, Cell,Lines, Cell
D002470 Cell Survival The span of viability of a cell characterized by the capacity to perform certain functions such as metabolism, growth, reproduction, some form of responsiveness, and adaptability. Cell Viability,Cell Viabilities,Survival, Cell,Viabilities, Cell,Viability, Cell
D002999 Clone Cells A group of genetically identical cells all descended from a single common ancestral cell by mitosis in eukaryotes or by binary fission in prokaryotes. Clone cells also include populations of recombinant DNA molecules all carrying the same inserted sequence. (From King & Stansfield, Dictionary of Genetics, 4th ed) Clones,Cell, Clone,Cells, Clone,Clone,Clone Cell

Related Publications

Marion Pepper, and Jonathan L Linehan, and Antonio J Pagán, and Traci Zell, and Thamotharampillai Dileepan, and P Patrick Cleary, and Marc K Jenkins
Human TH17 cells are long-lived effector memory cells.
October 2011, Science translational medicine,
Marion Pepper, and Jonathan L Linehan, and Antonio J Pagán, and Traci Zell, and Thamotharampillai Dileepan, and P Patrick Cleary, and Marc K Jenkins
Bordetella pertussis infection induces a mucosal IL-17 response and long-lived Th17 and Th1 immune memory cells in nonhuman primates.
July 2013, Mucosal immunology,
Marion Pepper, and Jonathan L Linehan, and Antonio J Pagán, and Traci Zell, and Thamotharampillai Dileepan, and P Patrick Cleary, and Marc K Jenkins
Th1 and Th17 cells induce proliferative glomerulonephritis.
December 2009, Journal of the American Society of Nephrology : JASN,
Marion Pepper, and Jonathan L Linehan, and Antonio J Pagán, and Traci Zell, and Thamotharampillai Dileepan, and P Patrick Cleary, and Marc K Jenkins
KLRG1+ Memory CD8 T Cells Combine Properties of Short-Lived Effectors and Long-Lived Memory.
August 2020, Journal of immunology (Baltimore, Md. : 1950),
Marion Pepper, and Jonathan L Linehan, and Antonio J Pagán, and Traci Zell, and Thamotharampillai Dileepan, and P Patrick Cleary, and Marc K Jenkins
Th17 cells induce Th1-polarizing monocyte-derived dendritic cells.
August 2013, Journal of immunology (Baltimore, Md. : 1950),
Marion Pepper, and Jonathan L Linehan, and Antonio J Pagán, and Traci Zell, and Thamotharampillai Dileepan, and P Patrick Cleary, and Marc K Jenkins
CD103+ lung dendritic cells (LDCs) induce stronger Th1/Th17 immunity to a bacterial lung infection than CD11bhi LDCs.
April 2018, Cellular & molecular immunology,
Marion Pepper, and Jonathan L Linehan, and Antonio J Pagán, and Traci Zell, and Thamotharampillai Dileepan, and P Patrick Cleary, and Marc K Jenkins
Th1, Th17, and Th9 effector cells induce experimental autoimmune encephalomyelitis with different pathological phenotypes.
December 2009, Journal of immunology (Baltimore, Md. : 1950),
Marion Pepper, and Jonathan L Linehan, and Antonio J Pagán, and Traci Zell, and Thamotharampillai Dileepan, and P Patrick Cleary, and Marc K Jenkins
[Th1, Th17 and Th1+17 cells].
December 2011, Zeitschrift fur Rheumatologie,
Marion Pepper, and Jonathan L Linehan, and Antonio J Pagán, and Traci Zell, and Thamotharampillai Dileepan, and P Patrick Cleary, and Marc K Jenkins
Subpopulations of long-lived and short-lived T cells in advanced HIV-1 infection.
September 2003, The Journal of clinical investigation,
Marion Pepper, and Jonathan L Linehan, and Antonio J Pagán, and Traci Zell, and Thamotharampillai Dileepan, and P Patrick Cleary, and Marc K Jenkins
Effector TH17 Cells Give Rise to Long-Lived TRM Cells that Are Essential for an Immediate Response against Bacterial Infection.
August 2019, Cell,
Copied contents to your clipboard!