Long-latency auditory evoked potentials during general anesthesia: N1 and P3 components. 1991

G Plourde, and T W Picton
Human Neurosciences Research Unit, University of Ottawa, Ontario, Canada.

The N1 and P3 auditory evoked potentials were recorded to evaluate their usefulness as measures of the level of consciousness in 14 ASA physical status I and II patients undergoing elective surgery. The anesthetic agents were thiopental, fentanyl, and isoflurane with or without nitrous oxide. Recordings were carried out before induction (preinduction) and during induction, surgical anesthesia, emergence, and recovery from anesthesia. The auditory response was evoked by 700-Hz tones that occurred occasionally and unpredictably in a train of 500-Hz tones delivered at 40 per second. The patients were asked to press a button whenever they detected a 700-Hz tone. Studies with normal subjects have repeatedly shown that detected tones (HITS) evoke N1 and P3 waves, whereas undetected tones (MISSES) evoke no recognizable waves. The responses evoked by HITS were compared with those evoked by MISSES. The amplitudes of N1 and P3 were significantly different from zero for HITS before induction and during induction and recovery but not during emergence. The amplitudes of N1 and P3 were not different from zero for MISSES during induction, surgery, and emergence. During recovery, the N1 and P3 for MISSES were small and the P3 for HITS was significantly larger than for MISSES. The results indicate that except during emergence, HITS were associated with clear N1 and P3 waves, whereas MISSES were not. The lack of either N1 or P3 for HITS during emergence perhaps occurred because the patients, although responsive, were not yet fully conscious. The N1 and P3 components of the auditory evoked potential may provide specific indicators for consciousness.

UI MeSH Term Description Entries
D007530 Isoflurane A stable, non-explosive inhalation anesthetic, relatively free from significant side effects.
D008297 Male Males
D009609 Nitrous Oxide Nitrogen oxide (N2O). A colorless, odorless gas that is used as an anesthetic and analgesic. High concentrations cause a narcotic effect and may replace oxygen, causing death by asphyxia. It is also used as a food aerosol in the preparation of whipping cream. Laughing Gas,Nitrogen Protoxide,Gas, Laughing,Oxide, Nitrous
D004347 Drug Interactions The action of a drug that may affect the activity, metabolism, or toxicity of another drug. Drug Interaction,Interaction, Drug,Interactions, Drug
D004569 Electroencephalography Recording of electric currents developed in the brain by means of electrodes applied to the scalp, to the surface of the brain, or placed within the substance of the brain. EEG,Electroencephalogram,Electroencephalograms
D005072 Evoked Potentials, Auditory The electric response evoked in the CEREBRAL CORTEX by ACOUSTIC STIMULATION or stimulation of the AUDITORY PATHWAYS. Auditory Evoked Potentials,Auditory Evoked Response,Auditory Evoked Potential,Auditory Evoked Responses,Evoked Potential, Auditory,Evoked Response, Auditory,Evoked Responses, Auditory,Potentials, Auditory Evoked
D005260 Female Females
D005283 Fentanyl A potent narcotic analgesic, abuse of which leads to habituation or addiction. It is primarily a mu-opioid agonist. Fentanyl is also used as an adjunct to general anesthetics, and as an anesthetic for induction and maintenance. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1078) Phentanyl,Duragesic,Durogesic,Fentanest,Fentanyl Citrate,Fentora,R-4263,Sublimaze,Transmucosal Oral Fentanyl Citrate,R 4263,R4263
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000328 Adult A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available. Adults

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