-transparent.png){kind=logo}
Synthesis and evaluation of 3'-azido-2',3'-dideoxypurine nucleosides as inhibitors of human immunodeficiency virus. 2010
Hong-Wang Zhang, and
Steven J Coats, and
Lavanya Bondada, and
Franck Amblard, and
Mervi Detorio, and
Ghazia Asif, and
Emilie Fromentin, and
Sarah Solomon, and
Aleksandr Obikhod, and
Tony Whitaker, and
Nicolas Sluis-Cremer, and
John W Mellors, and
Raymond F Schinazi
Center for AIDS Research, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine, and Veterans Affairs Medical Center, Atlanta, GA 30033, USA.
Based on the promising drug resistance profile and potent anti-HIV activity of beta-d-3'-azido-2',3'-dideoxyguanosine, a series of purine modified nucleosides were synthesized by a chemical transglycosylation reaction and evaluated for their antiviral activity, cytotoxicity, and intracellular metabolism. Among the synthesized compounds, several show potent and selective anti-HIV activity in primary lymphocytes.
Related Publications
Hong-Wang Zhang, and
Steven J Coats, and
Lavanya Bondada, and
Franck Amblard, and
Mervi Detorio, and
Ghazia Asif, and
Emilie Fromentin, and
Sarah Solomon, and
Aleksandr Obikhod, and
Tony Whitaker, and
Nicolas Sluis-Cremer, and
John W Mellors, and
Raymond F Schinazi
September 2009,
Antimicrobial agents and chemotherapy,
Hong-Wang Zhang, and
Steven J Coats, and
Lavanya Bondada, and
Franck Amblard, and
Mervi Detorio, and
Ghazia Asif, and
Emilie Fromentin, and
Sarah Solomon, and
Aleksandr Obikhod, and
Tony Whitaker, and
Nicolas Sluis-Cremer, and
John W Mellors, and
Raymond F Schinazi
June 1990,
Journal of medicinal chemistry,
Hong-Wang Zhang, and
Steven J Coats, and
Lavanya Bondada, and
Franck Amblard, and
Mervi Detorio, and
Ghazia Asif, and
Emilie Fromentin, and
Sarah Solomon, and
Aleksandr Obikhod, and
Tony Whitaker, and
Nicolas Sluis-Cremer, and
John W Mellors, and
Raymond F Schinazi
June 1990,
Journal of medicinal chemistry,
Hong-Wang Zhang, and
Steven J Coats, and
Lavanya Bondada, and
Franck Amblard, and
Mervi Detorio, and
Ghazia Asif, and
Emilie Fromentin, and
Sarah Solomon, and
Aleksandr Obikhod, and
Tony Whitaker, and
Nicolas Sluis-Cremer, and
John W Mellors, and
Raymond F Schinazi
December 1990,
Proceedings of the National Academy of Sciences of the United States of America,
Hong-Wang Zhang, and
Steven J Coats, and
Lavanya Bondada, and
Franck Amblard, and
Mervi Detorio, and
Ghazia Asif, and
Emilie Fromentin, and
Sarah Solomon, and
Aleksandr Obikhod, and
Tony Whitaker, and
Nicolas Sluis-Cremer, and
John W Mellors, and
Raymond F Schinazi
January 1991,
Nucleic acids symposium series,
Hong-Wang Zhang, and
Steven J Coats, and
Lavanya Bondada, and
Franck Amblard, and
Mervi Detorio, and
Ghazia Asif, and
Emilie Fromentin, and
Sarah Solomon, and
Aleksandr Obikhod, and
Tony Whitaker, and
Nicolas Sluis-Cremer, and
John W Mellors, and
Raymond F Schinazi
October 1989,
Nucleic acids research,
Hong-Wang Zhang, and
Steven J Coats, and
Lavanya Bondada, and
Franck Amblard, and
Mervi Detorio, and
Ghazia Asif, and
Emilie Fromentin, and
Sarah Solomon, and
Aleksandr Obikhod, and
Tony Whitaker, and
Nicolas Sluis-Cremer, and
John W Mellors, and
Raymond F Schinazi
August 1989,
Journal of medicinal chemistry,
Hong-Wang Zhang, and
Steven J Coats, and
Lavanya Bondada, and
Franck Amblard, and
Mervi Detorio, and
Ghazia Asif, and
Emilie Fromentin, and
Sarah Solomon, and
Aleksandr Obikhod, and
Tony Whitaker, and
Nicolas Sluis-Cremer, and
John W Mellors, and
Raymond F Schinazi
January 1988,
Annals of neurology,
Hong-Wang Zhang, and
Steven J Coats, and
Lavanya Bondada, and
Franck Amblard, and
Mervi Detorio, and
Ghazia Asif, and
Emilie Fromentin, and
Sarah Solomon, and
Aleksandr Obikhod, and
Tony Whitaker, and
Nicolas Sluis-Cremer, and
John W Mellors, and
Raymond F Schinazi
March 1994,
Journal of medicinal chemistry,
Hong-Wang Zhang, and
Steven J Coats, and
Lavanya Bondada, and
Franck Amblard, and
Mervi Detorio, and
Ghazia Asif, and
Emilie Fromentin, and
Sarah Solomon, and
Aleksandr Obikhod, and
Tony Whitaker, and
Nicolas Sluis-Cremer, and
John W Mellors, and
Raymond F Schinazi
July 1991,
Molecular pharmacology,
