BIOMAT Database Logo BIOMAT Database Logo

Water-soluble organometallic analogues of oxaliplatin with cytotoxic and anticlonogenic activity. 2010

Michele Benedetti, and Daniela Antonucci, and Danilo Migoni, and Vita M Vecchio, and Cosimo Ducani, and Francesco P Fanizzi
Dipartimento di Scienze e Tecnologie Biologiche ed Ambientali, Università del Salento, Via Provinciale Lecce-Monteroni, 73100 Lecce, Italy.

UI MeSH Term Description Entries
D009942 Organometallic Compounds A class of compounds of the type R-M, where a C atom is joined directly to any other element except H, C, N, O, F, Cl, Br, I, or At. (Grant & Hackh's Chemical Dictionary, 5th ed) Metallo-Organic Compound,Metallo-Organic Compounds,Metalloorganic Compound,Organometallic Compound,Metalloorganic Compounds,Compound, Metallo-Organic,Compound, Metalloorganic,Compound, Organometallic,Compounds, Metallo-Organic,Compounds, Metalloorganic,Compounds, Organometallic,Metallo Organic Compound,Metallo Organic Compounds
D009944 Organoplatinum Compounds Organic compounds which contain platinum as an integral part of the molecule. Compounds, Organoplatinum
D010984 Platinum A heavy, soft, whitish metal, resembling tin, with atomic number 78, atomic weight 195.084, symbol Pt. It is used in manufacturing equipment for laboratory and industrial use. It occurs as a black powder (platinum black) and as a spongy substance (spongy platinum) and may have been known in Pliny's time as "alutiae". Platinum Black
D006367 HeLa Cells The first continuously cultured human malignant CELL LINE, derived from the cervical carcinoma of Henrietta Lacks. These cells are used for, among other things, VIRUS CULTIVATION and PRECLINICAL DRUG EVALUATION assays. Cell, HeLa,Cells, HeLa,HeLa Cell
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000077150 Oxaliplatin An organoplatinum complex in which the platinum atom is complexed with 1,2-diaminocyclohexane, and with an oxalate ligand which is displaced to yield active oxaliplatin derivatives. These derivatives form inter- and intra-strand DNA crosslinks that inhibit DNA replication and transcription. Oxaliplatin is an antineoplastic agent that is often administered with FLUOROURACIL and FOLINIC ACID in the treatment of metastatic COLORECTAL NEOPLASMS. Platinum(2+) ethanedioate (1R,2R)-1,2-cyclohexanediamine (1:1:1),1,2-Diaminocyclohexane Platinum Oxalate,1,2-Diamminocyclohexane(trans-1)oxolatoplatinum(II),ACT 078,ACT-078,Cis-oxalato-(trans-l)-1,2-diaminocyclohexane-platinum(II),Eloxatin,Eloxatine,L-OHP Cpd,Oxalato-(1,2-cyclohexanediamine)platinum II,Oxaliplatin, (SP-4-2-(1R-trans))-isomer,Oxaliplatin, (SP-4-2-(1S-trans))-isomer,Oxaliplatin, (SP-4-3-(cis))-isomer,Oxaliplatine,Platinum(II)-1,2-cyclohexanediamine Oxalate,1,2 Diaminocyclohexane Platinum Oxalate,ACT078
D000970 Antineoplastic Agents Substances that inhibit or prevent the proliferation of NEOPLASMS. Anticancer Agent,Antineoplastic,Antineoplastic Agent,Antineoplastic Drug,Antitumor Agent,Antitumor Drug,Cancer Chemotherapy Agent,Cancer Chemotherapy Drug,Anticancer Agents,Antineoplastic Drugs,Antineoplastics,Antitumor Agents,Antitumor Drugs,Cancer Chemotherapy Agents,Cancer Chemotherapy Drugs,Chemotherapeutic Anticancer Agents,Chemotherapeutic Anticancer Drug,Agent, Anticancer,Agent, Antineoplastic,Agent, Antitumor,Agent, Cancer Chemotherapy,Agents, Anticancer,Agents, Antineoplastic,Agents, Antitumor,Agents, Cancer Chemotherapy,Agents, Chemotherapeutic Anticancer,Chemotherapy Agent, Cancer,Chemotherapy Agents, Cancer,Chemotherapy Drug, Cancer,Chemotherapy Drugs, Cancer,Drug, Antineoplastic,Drug, Antitumor,Drug, Cancer Chemotherapy,Drug, Chemotherapeutic Anticancer,Drugs, Antineoplastic,Drugs, Antitumor,Drugs, Cancer Chemotherapy
D013237 Stereoisomerism The phenomenon whereby compounds whose molecules have the same number and kind of atoms and the same atomic arrangement, but differ in their spatial relationships. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed) Molecular Stereochemistry,Stereoisomers,Stereochemistry, Molecular,Stereoisomer
D014867 Water A clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed) Hydrogen Oxide
D045744 Cell Line, Tumor A cell line derived from cultured tumor cells. Tumor Cell Line,Cell Lines, Tumor,Line, Tumor Cell,Lines, Tumor Cell,Tumor Cell Lines

Related Publications

Michele Benedetti, and Daniela Antonucci, and Danilo Migoni, and Vita M Vecchio, and Cosimo Ducani, and Francesco P Fanizzi
Water-soluble propofol analogues with intravenous anaesthetic activity.
April 2001, Bioorganic & medicinal chemistry letters,
Michele Benedetti, and Daniela Antonucci, and Danilo Migoni, and Vita M Vecchio, and Cosimo Ducani, and Francesco P Fanizzi
Water-soluble copper pyrithione complexes with cytotoxic and antibacterial activity.
March 2023, Organic & biomolecular chemistry,
Michele Benedetti, and Daniela Antonucci, and Danilo Migoni, and Vita M Vecchio, and Cosimo Ducani, and Francesco P Fanizzi
Drug delivery by water-soluble organometallic cages.
January 2012, Topics in current chemistry,
Michele Benedetti, and Daniela Antonucci, and Danilo Migoni, and Vita M Vecchio, and Cosimo Ducani, and Francesco P Fanizzi
Water-soluble, redox-active organometallic calcium chelators.
December 2012, Dalton transactions (Cambridge, England : 2003),
Michele Benedetti, and Daniela Antonucci, and Danilo Migoni, and Vita M Vecchio, and Cosimo Ducani, and Francesco P Fanizzi
A water soluble diruthenium-gold organometallic microgel.
January 2008, Angewandte Chemie (International ed. in English),
Michele Benedetti, and Daniela Antonucci, and Danilo Migoni, and Vita M Vecchio, and Cosimo Ducani, and Francesco P Fanizzi
WATER-SOLUBLE vitamin K analogues.
May 1959, Nutrition reviews,
Michele Benedetti, and Daniela Antonucci, and Danilo Migoni, and Vita M Vecchio, and Cosimo Ducani, and Francesco P Fanizzi
Simplified silvestrol analogues with potent cytotoxic activity.
July 2014, ChemMedChem,
Michele Benedetti, and Daniela Antonucci, and Danilo Migoni, and Vita M Vecchio, and Cosimo Ducani, and Francesco P Fanizzi
Oxaliplatin analogues with carboxy derivatives of boldine with enhanced antioxidant activity.
January 2015, Bioinorganic chemistry and applications,
Michele Benedetti, and Daniela Antonucci, and Danilo Migoni, and Vita M Vecchio, and Cosimo Ducani, and Francesco P Fanizzi
Fluorescent cisplatin analogues and cytotoxic activity.
January 2009, Current medicinal chemistry,
Michele Benedetti, and Daniela Antonucci, and Danilo Migoni, and Vita M Vecchio, and Cosimo Ducani, and Francesco P Fanizzi
Stable, water-soluble Pta-based Ru-Ag organometallic polymers.
April 2005, Angewandte Chemie (International ed. in English),
Copied contents to your clipboard!