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We investigated the characteristics of the antiplatelet autoantibodies in 60 patients with ITP. Using flow cytometry, the binding of monoclonal antibodies to the platelet glycoprotein (GP) IIb/IIIa complex and to GPIb was examined in these patients. The extent of binding was decreased in 15 patients (anti-GPIIb/IIIa in 12 patients and both anti-GPIIb/IIIa and anti-GPIb in 3 patients). Western blotting revealed that 10 of these 15 patients had either anti-GPIIb or anti-GPIIIa and 2 had anti-GPIb autoantibodies, ADP-induced aggregation of normal platelets was inhibited by autoantibodies in 12 of 60 patients, and 11 of these had anti-GPIIb/IIIa antibodies. Ristocetin-induced aggregation was inhibited in 4 of these patients, and 2 with prominent inhibition had anti-GPIb antibodies. There was a significant relationship between platelet-associated IgG value and ATP secretion. These results suggest that some antiplatelet autoantibodies can affect platelet function and thus have an influence on the pathophysiology of ITP.
M Yanabu, and
M Suzuki, and
T Soga, and
N Sone, and
H Nagata, and
S Nomura, and
T Kokawa, and
K Yasunaga
August 1992,
European journal of haematology,
M Yanabu, and
M Suzuki, and
T Soga, and
N Sone, and
H Nagata, and
S Nomura, and
T Kokawa, and
K Yasunaga
September 1998,
Transfusion science,
M Yanabu, and
M Suzuki, and
T Soga, and
N Sone, and
H Nagata, and
S Nomura, and
T Kokawa, and
K Yasunaga
July 1984,
Blood,
M Yanabu, and
M Suzuki, and
T Soga, and
N Sone, and
H Nagata, and
S Nomura, and
T Kokawa, and
K Yasunaga
October 1978,
Scandinavian journal of haematology,
M Yanabu, and
M Suzuki, and
T Soga, and
N Sone, and
H Nagata, and
S Nomura, and
T Kokawa, and
K Yasunaga
November 2022,
Blood,
M Yanabu, and
M Suzuki, and
T Soga, and
N Sone, and
H Nagata, and
S Nomura, and
T Kokawa, and
K Yasunaga
October 1976,
JAMA,
M Yanabu, and
M Suzuki, and
T Soga, and
N Sone, and
H Nagata, and
S Nomura, and
T Kokawa, and
K Yasunaga
September 1976,
British journal of haematology,
M Yanabu, and
M Suzuki, and
T Soga, and
N Sone, and
H Nagata, and
S Nomura, and
T Kokawa, and
K Yasunaga
July 2000,
Seminars in hematology,
M Yanabu, and
M Suzuki, and
T Soga, and
N Sone, and
H Nagata, and
S Nomura, and
T Kokawa, and
K Yasunaga
October 1989,
Blood,
M Yanabu, and
M Suzuki, and
T Soga, and
N Sone, and
H Nagata, and
S Nomura, and
T Kokawa, and
K Yasunaga
August 1977,
Blood,
