Occupational immediate-type asthma and rhinitis due to rhodium salts. 2010

Rolf Merget, and Ingrid Sander, and Vera van Kampen, and Monika Raulf-Heimsoth, and Hans-Martin Ulmer, and Rupprecht Kulzer, and Thomas Bruening
Research Institute of Occupational Medicine, German Social Accident Insurance (BGFA), Ruhr University, Bürkle-de-la-Camp-Platz 1, Bochum, Germany. merget@bgfa.de

BACKGROUND Whereas platinum salts are well known occupational allergens, rhodium salts have not been identified as inhalative sensitizing substances. METHODS A 27-year-old atopic operator of an electroplating plant developed work-related shortness of breath and runny nose with sneezing after exposure to rhodium salts. Quantitative skin prick tests (SPT) and bronchial challenge tests with a dosimeter protocol were performed with quadrupling doses of the sodium chloride salts of rhodium (Na(3)RhCl(6)) and platinum (Na(2)PtCl(6)). RESULTS The patient showed positive SPT reactions and positive bronchial immediate-type reactions with rhodium and platinum salts. Sensitivity to rhodium salt was much higher than to platinum salt; the molar concentrations differed by a factor of 256 in SPT and a factor of 16 in bronchial challenges. CONCLUSIONS Rhodium salts should be considered as occupational immediate-type allergens.

UI MeSH Term Description Entries
D006969 Hypersensitivity, Immediate Hypersensitivity reactions which occur within minutes of exposure to challenging antigen due to the release of histamine which follows the antigen-antibody reaction and causes smooth muscle contraction and increased vascular permeability. Atopic Hypersensitivity,Hypersensitivity, Atopic,Hypersensitivity, Type I,IgE-Mediated Hypersensitivity,Type I Hypersensitivity,Atopic Hypersensitivities,Hypersensitivities, Atopic,Hypersensitivities, IgE-Mediated,Hypersensitivities, Immediate,Hypersensitivities, Type I,Hypersensitivity, IgE-Mediated,IgE Mediated Hypersensitivity,IgE-Mediated Hypersensitivities,Immediate Hypersensitivities,Immediate Hypersensitivity,Type I Hypersensitivities
D007428 Intradermal Tests Skin tests in which the sensitizer is injected. Passive Transfer Test,Prausnitz-Kustner Test,Intradermal Test,Passive Transfer Tests,Prausnitz Kustner Test,Test, Intradermal,Test, Passive Transfer,Test, Prausnitz-Kustner,Tests, Intradermal,Tests, Passive Transfer
D008297 Male Males
D009784 Occupational Diseases Diseases caused by factors involved in one's employment. Diseases, Occupational,Occupational Illnesses,Disease, Occupational,Illnesse, Occupational,Illnesses, Occupational,Occupational Disease,Occupational Illnesse
D010984 Platinum A heavy, soft, whitish metal, resembling tin, with atomic number 78, atomic weight 195.084, symbol Pt. It is used in manufacturing equipment for laboratory and industrial use. It occurs as a black powder (platinum black) and as a spongy substance (spongy platinum) and may have been known in Pliny's time as "alutiae". Platinum Black
D001985 Bronchial Provocation Tests Tests involving inhalation of allergens (nebulized or in dust form), nebulized pharmacologically active solutions (e.g., histamine, methacholine), or control solutions, followed by assessment of respiratory function. These tests are used in the diagnosis of asthma. Allergen Bronchial Provocation Tests,Allergen Challenge, Endobronchial,Antigen Bronchial Provocation Tests,Bronchial Allergen Challenge,Bronchial Challenge Tests,Inhalation Provocation Tests,Provocation Tests, Bronchial,Endobronchial Challenge Tests,Allergen Challenge, Bronchial,Allergen Challenges, Bronchial,Allergen Challenges, Endobronchial,Bronchial Allergen Challenges,Bronchial Challenge Test,Bronchial Provocation Test,Challenge Test, Bronchial,Challenge Test, Endobronchial,Challenge Tests, Bronchial,Challenge Tests, Endobronchial,Challenge, Bronchial Allergen,Challenge, Endobronchial Allergen,Challenges, Bronchial Allergen,Challenges, Endobronchial Allergen,Endobronchial Allergen Challenge,Endobronchial Allergen Challenges,Endobronchial Challenge Test,Inhalation Provocation Test,Provocation Test, Bronchial,Provocation Test, Inhalation,Provocation Tests, Inhalation,Test, Bronchial Challenge,Test, Bronchial Provocation,Test, Endobronchial Challenge,Test, Inhalation Provocation,Tests, Bronchial Challenge,Tests, Bronchial Provocation,Tests, Endobronchial Challenge,Tests, Inhalation Provocation
D004305 Dose-Response Relationship, Drug The relationship between the dose of an administered drug and the response of the organism to the drug. Dose Response Relationship, Drug,Dose-Response Relationships, Drug,Drug Dose-Response Relationship,Drug Dose-Response Relationships,Relationship, Drug Dose-Response,Relationships, Drug Dose-Response
D004595 Electroplating Coating with a metal or alloy by electrolysis. Electrodeposition,Metal Plating,Plating, Metal
D005541 Forced Expiratory Volume Measure of the maximum amount of air that can be expelled in a given number of seconds during a FORCED VITAL CAPACITY determination . It is usually given as FEV followed by a subscript indicating the number of seconds over which the measurement is made, although it is sometimes given as a percentage of forced vital capacity. Forced Vital Capacity, Timed,Timed Vital Capacity,Vital Capacity, Timed,FEVt,Capacities, Timed Vital,Capacity, Timed Vital,Expiratory Volume, Forced,Expiratory Volumes, Forced,Forced Expiratory Volumes,Timed Vital Capacities,Vital Capacities, Timed,Volume, Forced Expiratory,Volumes, Forced Expiratory
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man

Related Publications

Rolf Merget, and Ingrid Sander, and Vera van Kampen, and Monika Raulf-Heimsoth, and Hans-Martin Ulmer, and Rupprecht Kulzer, and Thomas Bruening
February 2005, Allergy,
Rolf Merget, and Ingrid Sander, and Vera van Kampen, and Monika Raulf-Heimsoth, and Hans-Martin Ulmer, and Rupprecht Kulzer, and Thomas Bruening
July 2016, Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology,
Rolf Merget, and Ingrid Sander, and Vera van Kampen, and Monika Raulf-Heimsoth, and Hans-Martin Ulmer, and Rupprecht Kulzer, and Thomas Bruening
June 2008, Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology,
Rolf Merget, and Ingrid Sander, and Vera van Kampen, and Monika Raulf-Heimsoth, and Hans-Martin Ulmer, and Rupprecht Kulzer, and Thomas Bruening
January 2013, Advances in experimental medicine and biology,
Rolf Merget, and Ingrid Sander, and Vera van Kampen, and Monika Raulf-Heimsoth, and Hans-Martin Ulmer, and Rupprecht Kulzer, and Thomas Bruening
June 2006, International archives of occupational and environmental health,
Rolf Merget, and Ingrid Sander, and Vera van Kampen, and Monika Raulf-Heimsoth, and Hans-Martin Ulmer, and Rupprecht Kulzer, and Thomas Bruening
September 2014, Contact dermatitis,
Rolf Merget, and Ingrid Sander, and Vera van Kampen, and Monika Raulf-Heimsoth, and Hans-Martin Ulmer, and Rupprecht Kulzer, and Thomas Bruening
September 2003, Allergy,
Rolf Merget, and Ingrid Sander, and Vera van Kampen, and Monika Raulf-Heimsoth, and Hans-Martin Ulmer, and Rupprecht Kulzer, and Thomas Bruening
March 2010, Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology,
Rolf Merget, and Ingrid Sander, and Vera van Kampen, and Monika Raulf-Heimsoth, and Hans-Martin Ulmer, and Rupprecht Kulzer, and Thomas Bruening
July 2003, Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology,
Rolf Merget, and Ingrid Sander, and Vera van Kampen, and Monika Raulf-Heimsoth, and Hans-Martin Ulmer, and Rupprecht Kulzer, and Thomas Bruening
August 2011, Occupational medicine (Oxford, England),
Copied contents to your clipboard!