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[Efficacy and safety of infliximab in patients with rheumatoid arthritis]. 2009
Wen Zhang, and
Qun Shi, and
Dong-hai Wu, and
Chun-de Bao, and
Nan-ping Yang, and
Zhan-guo Li, and
Ping Zhu, and
Xiao Zhang, and
Ci-bo Huang, and
Dong-yi He, and
Zhi-zhong Ye, and
Yi Tao, and
Yong-fei Fang, and
Jie-ruo Gu, and
Hua-xiang Wu, and
Ling-yun Sun, and
Xiu-yan Yang, and
Feng Huang, and
Hu-ji Xu, and
Dong-bao Zhao, and
Miao-jia Zhang, and
Yi Zheng, and
Mai-xing Ai, and
Jun Lu, and
Feng-chun Zhang
Department of Rheumatology and Immunology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100730, China. zhangsamfc@hotmail.com
OBJECTIVE To investigate the efficacy and safety of Infliximab (IFX) plus methotrexate (MTX) combination therapy in patients with rheumatoid arthritis (RA). METHODS Prospectively observe refractory RA patients who were treated with combination therapy of MTX and IFX. IFX was infused at the dosage of 3 mg/kg, in week 0, 2, 6, and then every 8 weeks. During treatment, clinical variables, disease activity and adverse effects were evaluated. RESULTS After treatment, 69.8%, 52.4%, 29.5% and 7.2% RA patients achieved ACR20, ACR50, ACR70 and ACR90 respectively. There were significant statistical differences in the changes of swollen joint counts, tender joint counts, VAS scale, patient' s global assessment, and physician's global assessment before and after therapy. CONCLUSIONS Infliximab plus MTX achieved significant efficacy and safety in refractory RA patients.
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