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BACKGROUND Wire-localized breast biopsy (WLBB) remains the standard method for the surgical excision of nonpalpable breast lesions. Because of many of its shortcomings, most important a high microscopic positive margin rate, alternative approaches have been described, including radioactive seed localization (RSL). This review highlights the literature regarding RSL, including safety, the ease of the procedure, billing, and oncologic outcomes. METHODS Medline and PubMed were searched using the terms "radioactive seed" and "breast." All peer-reviewed studies were included in this review. CONCLUSIONS RSL is a promising approach for the resection of nonpalpable breast lesions. It is a reliable and safe alternative to WLBB. RSL is at least equivalent compared with WLBB in terms of the ease of the procedure, removing the target lesion, the volume of breast tissue excised, obtaining negative margins, avoiding a second operative intervention, and allowing for simultaneous axillary staging.
James W Jakub, and
Richard J Gray, and
Amy C Degnim, and
Judy C Boughey, and
Mary Gardner, and
Charles E Cox
January 2019,
Revista espanola de medicina nuclear e imagen molecular,
James W Jakub, and
Richard J Gray, and
Amy C Degnim, and
Judy C Boughey, and
Mary Gardner, and
Charles E Cox
April 2013,
The British journal of surgery,
James W Jakub, and
Richard J Gray, and
Amy C Degnim, and
Judy C Boughey, and
Mary Gardner, and
Charles E Cox
January 2022,
Revista espanola de medicina nuclear e imagen molecular,
James W Jakub, and
Richard J Gray, and
Amy C Degnim, and
Judy C Boughey, and
Mary Gardner, and
Charles E Cox
January 2018,
Acta biomaterialia,
James W Jakub, and
Richard J Gray, and
Amy C Degnim, and
Judy C Boughey, and
Mary Gardner, and
Charles E Cox
August 2013,
The British journal of surgery,
James W Jakub, and
Richard J Gray, and
Amy C Degnim, and
Judy C Boughey, and
Mary Gardner, and
Charles E Cox
November 2017,
Current radiopharmaceuticals,
James W Jakub, and
Richard J Gray, and
Amy C Degnim, and
Judy C Boughey, and
Mary Gardner, and
Charles E Cox
January 2006,
Radiology case reports,
James W Jakub, and
Richard J Gray, and
Amy C Degnim, and
Judy C Boughey, and
Mary Gardner, and
Charles E Cox
February 2015,
Journal of surgical oncology,
James W Jakub, and
Richard J Gray, and
Amy C Degnim, and
Judy C Boughey, and
Mary Gardner, and
Charles E Cox
April 1986,
La Radiologia medica,
James W Jakub, and
Richard J Gray, and
Amy C Degnim, and
Judy C Boughey, and
Mary Gardner, and
Charles E Cox
July 1996,
JPMA. The Journal of the Pakistan Medical Association,
